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Biomedical subjects

L Rabow

Publications and source records attributed to L Rabow.

34 records · Page 2Linked to original sources
PubMed1986

CSF brain creatine kinase levels and lactic acidosis in severe head injury.

The posttraumatic creatine kinase-BB isoenzyme (CKBB) activity and lactate concentration in ventricular cerebrospinal fluid (CSF) have been studied in 29 patients with severe head injuries. The CKBB activity reaches its maximum a few hours after trauma, and has a monoexponential drop with a half-time of approximately 10 hours. Ventricular CSF lactate concentration continues to rise in patients with a poor outcome, and decreases only slowly and inconsistently in most of the other patients. Thus, increase of lactate in the ventricular CSF is not, like CKBB, a direct one-stage consequence of the trauma but is due to continuous production from a derangement of metabolism caused by the trauma. Since even higher ventricular CSF lactate levels can be survived when not caused by head injury, and since no significant pH changes were related to the ventricular CSF lactic acidosis in these artificially ventilated patients, it is concluded that ventricular CSF lactic acidosis is indicative of a severe, although not necessarily intractable, disturbance of brain function associated with intracellular lactate production and acidosis.

Acidosis, Lactic↗
PubMed1985

Creatine kinaseBB-activity after head trauma related to outcome.

The brain-type isoenzyme of creatine kinase was determined in serum (S) and cerebrospinal fluid (CSF) in 37 patients with severe head injury, and a correlation was made with the Glasgow coma score and Glasgow outcome score. All patients with normal S-CKBB and CSF-CKBB activities had a coma score of 15, i.e., no neurological deficits, at six hours after the trauma and a good outcome. All 15 patients with a significant increase in the enzyme in serum and CSF had a coma score less than 15. The outcome was still good for five of these patients, while six were moderately disabled, two were severely disabled, and two died. There was no correlation between the individual CKBB-values and the outcome.

Adolescent↗
PubMed1985

Internal neurolysis or ligament division only in carpal tunnel syndrome--results of a randomized study.

In a series of patients with clinically and neurophysiologically well defined carpal tunnel syndrome a randomization has been made into two groups, one for operation with internal neurolysis and a microscopical technique, and the other group for cutting of the carpal ligament (flexor retinaculum) alone. The two groups have been compared postoperatively regarding clinical and neurophysiological parameters. All patients improved, 89% in both groups considered themselves totally free of symptoms at follow-up examinations but there was no significant difference in any parameter between the two groups. As a conclusion the use of internal neurolysis cannot be recommended as a routine procedure in carpal tunnel syndrome.

Adult↗
PubMed1979

CKBB-isoenzymes as a sign of cerebral injury.

CKBB-isoenzymes in serum and CSF have been shown to be raised in patients after head injury with objective signs of damaged brain tissues (contusio cerebri), but not in the absence of these signs (commotio cerebri).

Brain Concussion↗
PubMed1977

Serum activities of hydroxybutyrate dehydrogenase (HBD) and the isoenzymes of lactate dehydrogenase (LD) as an index of traumatic brain injury.

The lactate dehydrogenase (LD), the hydroxybutyrate dehydrogenase (HBD), and the LD isoenzyme activities in serum were followed in the posttraumatic period in 113 patients with cranio-cerebral injury, 70 of whom had verified brain contusion--laceration. In patients with brain contusion the HBD activity, known to be exerted mainly by the anodal LD isoenzyme fractions dominating in brain tissue, was significantly raised in 91% of the blood samples taken within four hours, and in 92% of the samples taken between 12 and 24 hours after trauma, while it was within normal limits in all the samples taken within four hours in patients with brain concussion, and increased in only 17% of the concussion patients 12-24 hours after trauma. The LD1 and the LD1+2 activities were of less diagnostic importance in blood samples taken during the first 24 hours. However, after 24 hours the LD1 activity was as informative as the HBD activity. The LD1 activity was normal in all concussion patients from the third day after trauma, while 78% of the contusion patients still showed raised LD1 activity then. The determination of HBD activity in serum in the immediate post-traumatic period is recommended as an appropriate method for screening parenchymatous brain injury. A complete LD isoenzyme separation may later add some further information in doubtful cases.

Adolescent↗
PubMed1977

Lactate dehydrogenase (LD), hydroxybutyrate dehydrogenase (HBD), and LD-isoenzymes in brain tissue.

The total activities of lactate dehydrogenase (LD) and hydroxybutyrate dehydrogenase (HBD), and the LD isoenzyme distribution were determined in tissue samples taken in vivo from different parts of the rabbit brain, and in cortical grey, subcortical white, and cerebellar tissue from man. The total LD and HBD activities were found to be higher in the brain stem than in the cerebral hemisphere, basal ganglia, and cerebellum of the rabbit brain. The isoenzyme distribution in the brain stem and the cerebellum showed an anodal shift, i.e., significantly higher activities of LD1 compared with the cerebral hemisphere and the basal ganglia. In man the total LD activity was found to be lower in white than in grey matter, although the isoenzyme patterns did not differ. The implications of these findings in relation to the LD isoenzyme pattern in serum after traumatic brain injury are discussed.

Animals↗
PubMed1977

Changes in lactate dehydrogenase isoenzyme patterns in patients with tumours of the central nervous system.?

The total activities of lactate dehydrogenase (LD) and the LD isoenzyme distribution were determined on homogenates from 61 benign and malignant intracranial tumours, and in serum and cerebrospinal fluid from 45 and 28 of the tumour patients respectively. The LD activity and the LD isoenzyme distribution in serum were not changed in patients with intracranial tumours. The LD activity in the cerebrospinal fluid was raised in about 50% of the tumour patients, but without any significant differences between patients with benign and malignant tumours. Except for very low activities in acoustic schwannomas and in pituitary adenomas, the tumour tissue did not differ significantly from normal brain in total LD activity. The LD isoenzyme distribution showed a pronounced cathodal shift in the grade 3-4 astrocytomas and the metastatic carcinomas, but an anodal shift in the grade 1-2 astrocytomas and the oligodendrogliomas. The meningiomas and the ocoustic schwannomas showed a midzone isoenzyme pattern with a dominant LD3 fraction. Knowledge of the LD isoenyme distribution can thus sometimes be a complement to the histological examination in the classification of brain tumours.

Adenoma↗
PubMed1975

Serum enzyme activity of hydroxybutyric dehydrogenase (HBD) and heat inactivated lactate dehydrogenase (LD) after operations on intracranial aneurysms.

The relation between clinical signs of parenchymatous cell damage after brain surgery and the serum activity of the LD-isoenzymes determined either as HBD or as heat inactivated LD, has been studied in 44 patients operated upon for intracranial aneurysms. Seven patients had a postoperative increase of the serum enzyme activity above the upper normal limit. All these showed neurological symptoms as compared to only 14% of those who had a postoperative enzyme level within normal limits. This speaks strongly in favour of a relation between the brain cell damage and the increase of the serum activity of the LD-isoenzyme. Since only 15% of the patients had a pathological enzyme level, it is further suggested that an uncomplicated operation for intracranial aneurysm should not cause an increase of the HBD or heat inactivated LD above the upper normal limit.

Adult↗