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Biomedical subjects

L Romics

Publications and source records attributed to L Romics.

At least 91 records · Page 5Linked to original sources
PubMed1988

The effects of probucol on QT/QS2 relation and systolic time intervals.

The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day. Both QT and QTc intervals increased significantly, whereas no significant changes were observed between the pre- and post-treatment QT/QS2 and pre-ejection period-left ventricular ejection time ratios. These results help to explain why treatment with probucol, while effecting a prolongation of the QTc interval, does not result in serious arrhythmias in man.

Adult↗
PubMed1988

Sex- and age-dependence of platelet aggregation in diabetes mellitus.

Platelet aggregate ratios (PAR) were determined, and threshold concentrations (ED50) of epinephrine, adenosine diphosphate (ADP), and collagen were estimated by platelet aggregometry in 88 IDDM and 52 NIDDM patients without hyperlipidaemia or azotaemia, and in 106 healthy volunteers to revise the question of hyperaggregability in diabetes. ED50-s showed a tendency for negative correlation with age, significant in female but not in male controls. Similar trends were obtained in IDDM and NIDDM females, but were not in IDDM and NIDDM males. The ED50-s of different aggregating agents positively correlated with each other. ED50-s were higher in men than in women in both controls and IDDM patients. Similar but minor differences were observed between women and men in NIDDM. IDDM patients had significantly lower PAR and collagen ED50, and a tendency for epinephrine and ADP to be lower as compared to the sex- and age-matched controls. The differences of PAR were the same, while those of ED50-s were diminished in older NIDDM patients compared to the matched controls. It is concluded, that the previously observed general hyperaggregability in diabetic patients may have partly resulted from sex- and age differences. Threshold concentrations should be compared to sex- and age-matched controls.

Adolescent↗
PubMed1987

Effect of growth hormone on serum lipoproteins in growth hormone deficiency.

The effect of growth hormone treatment on the plasma lipoproteins was studied in 13 growth hormone deficient children. The pretreatment total cholesterol level was moderately (p less than 0.05) higher in growth hormone deficiency and it decreased significantly under the effect of growth hormone administration. This decrease was due to the reduction of HDL-cholesterol in the first week and to the decrease of LDL-cholesterol after one month of treatment. The level of LDL-cholesterol returned to normal at one month. The plasma triglyceride level increased significantly under the effect of growth hormone in the first week and returned to normal after one month. This change was due to the increase of VLDL-triglyceride level. There was no difference in the cholesterol and triglyceride concentrations of growth hormone deficient children with normal or subnormal plasma thyroxine concentrations.

Adolescent↗
PubMed1985

Screening of children with high familial risk of arteriosclerosis.

Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) and total triglyceride levels were determined in children with high risk arteriosclerotic family history. Significantly higher TC and lower HDL-C levels were found in children whose parents' first arteriosclerotic sign had appeared before 40 years of age. There were no similar significant alterations observed in children whose parents' first arteriosclerotic symptom appeared after the forties. Screening therefore seems to be necessary in the offsprings of patients if the first sign of arteriosclerosis has been detected before 40 years of age.

Adolescent↗
PubMed1983

Serum lipids during starvation in obesity.

The HDL-cholesterol level was found to decrease during the first week of therapeutic starvation in hyperlipoproteinaemic (hypertriglyceridaemic), diabetic (non-insulin dependent) patients. The possible causes of the finding are discussed, and the view is expressed that the fall in HDL given no cause for discontinuing the caloric restriction or starvation as the therapeutic measures in obesity.

Adult↗
PubMed1983

[Cholesterol elimination in the urinary tract].

The case of a 50-year-old female patient who had been passing "calculi" containing cholesterol for 10 years is presented. Previously, abdominal surgical interventions had been carried out several times and therefore a fistula between the digestive and urogenital system was suspected. This, however, could not be confirmed either by radiological or laboratory techniques. A II/a type of hyperlipoproteinemia was found in the serum, but its correlation to the calculi could be excluded.

Cholesterol↗
PubMed1982

Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus.

In diabetic patients with poor metabolic control (Group I) and with repeated hypoglycaemic crises (Group II) the serum concentration of cholesterol, triglyceride, of LDL, VLDL and HDL-cholesterol, as well of VLDL and LDL + HDL-triglyceride were measured before and after metabolic control and before and after control of the hypoglycaemic crises. Parallel with the control of diabetic metabolism in Group I, achieved in 15 +/- 6 days, a significant increase in HDL-cholesterol concentration was demonstrable, together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion. In the diabetic patients of Group I, the LDL-cholesterol, serum triglyceride and VLDL-triglyceride levels were significantly higher, the HDL cholesterol levels significantly lower before as well as after metabolic correction, than in the control group. In Group II the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises. The results indicate that lipid metabolism in diabetes may considerably be affected by insulin deficiency, but it will respond to an intensified insulin effect. An increase in the concentration of the antiatherogenic HDL-cholesterol is an essential factor of the improvement.

Adult↗