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Biomedical subjects

L Singer

Publications and source records attributed to L Singer.

At least 91 records · Page 5Linked to original sources
PubMed1983

Effect of lactation and/or calcium deficiency on cyclic-AMP production and bone enzyme activities in rats: lack of effect of long-term fluoride administration.

The effect of 50 ppm F as sodium fluoride in the drinking water for 15 weeks on bone, plasma, and urinary cAMP levels, and on bone alkaline and acid phosphatase activities have been investigated in rats stressed with calcium deficiency and/or lactation, as well as in normal rats. Lactation and calcium deficiency (0.1% calcium in diet) was found to cause an increase in urinary cAMP excretion but did not cause any significant alteration in plasma and bone cAMP levels. Bone alkaline and acid phosphatase activities were lower in lactating rats furnished the 1.0% calcium diet when compared to the nonlactating controls. Fluoride had no effect on all parameters studied.

Acid Phosphatase↗
PubMed1983

[Treatment of generalized anxiety].

It has been recently hypothesized that anxiety is heterogeneous. Generalized anxiety and panic disorders could be separate entities with specific treatments, as suggested by the fact that some clinical forms of anxiety can be distinguished by characteristic therapeutic responses. The generalized anxiety treatments include benzodiazepines, verbal psychotherapy and relaxation training; they are non mutually exclusive. Nevertheless, at the present time no rational criteria allow to select the best treatment for a particular patient.

Anti-Anxiety Agents↗
PubMed1983

Laboratory investigation of the abnormal voice.

The patient with an abnormal voice has variously been investigated by laryngologists and speech pathologists, the diagnosis being based on visualization of the larynx and the sound of the voice. With the advent of phoniatric surgery, for example augmentation of the vocal cord and recurrent nerve section for spastic dysphonia, more objective means of quantifying abnormalities and results became pressing. Investigation of dysphonia where obvious lesions of the vocal cords were absent required further laboratory methods. The advent of microprocessors and fiberoptic endoscopy allows research methods to be applied clinically with better ability to diagnose and document patients with voice disorders. This paper outlines the experience of a voice laboratory and tries to assess the relevance of laboratory tests to clinical practice.

Electromyography↗
PubMed1982

[Open study of bromapezan in ambulatory and psychiatric hospital patients (author's transl)].

Psychiatrists working in hospital and in private practice took part in co-operative trial aimed at evaluating the effectiveness and safety of bromazepam. The study was of the open type and involved 10 hospital patients and 20 ambulatory patients. The same protocole was followed for each patient. Twenty-five patients (including 5 in hospital) had anxiety neurosis; the remaining 5 had anxiety following weaning from alcohol. The anxiolytic effects of the drug, determined by means of Hamilton's anxiety scale and overall clinical judgement, were generally found to be satisfactory. The effective doses ranged from 1 to 3 tablets per day in ambulatory patients and from 3 to 5 tablets per day in hospital patients. The main side-effects were related to unwanted sedation; they only occurred with the higher doses and rarely interfered with the beneficial effects of bromazepam.

Adult↗
PubMed1982

A comparison of methods used in root canal sealability studies.

The purpose of the study was to compare several methods that have been used to assess marginal leakage of root canal fillings. Sixty-three extracted, single-rooted teeth were instrumented and filled in a standardized manner. Teeth were randomly divided into groups of twenty and exposed to solutions containing methylene blue dye, calcium-45, carbon-14-labeled urea, and iodine-125-labeled albumin for 48 hours to compare the degree of leakage indicated by each technique. Methylene blue dye was found to penetrate farther up the canal than any of the isotope tracers. Carbon-14-labeled urea penetrated farther than the calcium-45- or iodine-125-labeled albumin. The mean volume of solution penetrating the teeth was exceedingly small (0.0011 ml) and probably unimportant physiologically.

Calcium Radioisotopes↗
PubMed1982

[Frequencies of HLA-A, C and Bf antigens in schizophrenic patients originated from Alsace (author's transl)].

A comparison of the frequency of HLA-A, B, C and Bf antigens observed in a group of 75 chronic schizophrenics and in a control group of 184, all strictly from Alsace, does not carry any argument in favour of a strong genetic association between schizophrenia and the antigens studied. In effect, the modifications observed in the schizophrenic sample--decrease in the frequency of A10 and B5 antigens, and increase of A29 and BfF--are not statistically significant when the probabilities are multiplied by the number of tested antigens. These preliminary results however do not permit to exclude the possibility of an association between schizophrenia and the tested antigens.

Adolescent↗
PubMed1981

[A study of thyroid function in patients with psychoaffective disease (author's transl)].

The purpose of the present study was to investigate dysfunctions in thyroid gland secretion and regulation among patients with manic-depressive psychosis. Plasma levels of thyroxine (T4), triiodothyronine (T3) and thyroid stimulating hormone (TSH) were measured by radioimmune assays, and TSH responsiveness (delta TSH) to synthetic TSH-releasing hormone (TRH) 250 microgram IV was determined in 20 untreated patients, 19 patients under neuroleptics and 19 patients under antidepressants. Untreated patients were compared with 15 age - and sex-matched controls. They were found to have significantly lower plasma T3 levels than controls (121.0 +/- 6.0 ng/dl as against 144.5 +/- 3.3 ng/dl; p less than 0.01) and blunted TSH response to TRH (delta TSH 4.1 +/- 0.6 instead of 12.6 +/- 2.1). Other thyroid function parameters were unchanged. Under neuroleptic treatment T3 levels tended to increase and delta TSH returned to normal. Manic-depressive psychosis is characterized by hypothalamic-pituitary dysfunction. Thyroid secretion is normal, and the decrease in T3 is probably due to impaired peripheral T4 to T3 conversion.

Bipolar Disorder↗
PubMed1981

Effect of lactation and calcium deficiency, and of fluoride intake, on bone turnover in rats: isotopic measurements of bone resorption and formation.

The rates of bone formation and resorption were investigated, using isotopic measurements, in calcium-deficient lactating rats and compared to those of calcium-sufficient non-lactating animals. Bone formation was measured by 3H-proline uptake and 3H-hydroxyproline formation, and resorption was measured by the loss of previously incorporated 3H-tetracycline, in whole humerus. The effect of 50 ppm fluoride in the drinking water on both parameters was also examined. The stress of lactation and calcium deficiency significantly increased the rates of bone resorption and formation, but the increase in resorption was greater than in formation which resulted in a net decrease in bone mineral and matrix. Fluoride had no effect on various parameters measured.

Animals↗