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Biomedical subjects

L Sprincl

Publications and source records attributed to L Sprincl.

At least 19 recordsLinked to original sources
PubMed1989

[Immunohistochemical classification of hypophyseal adenomas].

Immunohistochemical analysis showed production of hormones in more than half of 88 pituitary adenomas that were classified mostly as chromophobe in basic staining during 3 years. Prolactin was the most often detected. A combined production of hormones especially of prolactin and growth hormone was not exceptional. Using a sensitive double indirect immunoperoxidase technique enables economy in spending primary antibodies. Evaluation of hormonal production is important for selection of therapy, as well as for settlement of prognosis.

Adenoma↗
PubMed1987

Patterns of in vitro behaviour characterizing cells of spontaneously metastasizing K2M rat sarcoma.

Cells of K2M rat sarcoma and their descendants (RP, RPS) form tumours in syngeneic inbred rat strain LEW/CUB. Thirty to fifty per cent of tumour-bearing rats develop metastases, preferentially in the lung. In vitro, a quasi-stellate dynamic morphotype was characteristic of K2M cells and their descendants (RP, RPS): a highly changeable round or spindle-shaped or multipolar rather thick cell body with two or more protrusions of various length, often branching, and broadened at the tips, where vivid membrane activity was observed. Changeability of appearance and directionality of locomotion were stimulated in medium of pH 6.5. The enhanced expression of this morphotype correlated with the increased metastatic potential. In vitro, in poor, slightly acid medium metastasizing cells preserved the quasi-stellate dynamic morphotype and survived longer than non-metastasizing cells. It is likely that the observed combination of traits, viz. the quasi-stellate dynamic morphotype and, under unfavourable conditions, prolonged survival, increased migratory activity and decreased mitotic rate could be of significance in the metastatic cascade, mainly for the escape from the primary site.

Actins↗
PubMed1985

[Use of a computer program in the diagnosis of brain tumors].

The FEL-EXPERT was used to improve the diagnosis of brain tumors. Basic structure and decision process of the system were characterized. In a group of 70 testing cases the correct diagnosis was established at the 1st possibility in 83%, as the 1st or 2nd possibility in 91% and as the 1st or 2nd or 3rd possibility in 17%.

Artificial Intelligence↗
PubMed1984

[Carcinoma of the hypophysis with acromegaly].

A 38-year old man deceased after being operated on recurring pituitary adenoma removed 13 years ago. Autopsy showed a massive spread of tumour on dura and in subarachnoid space. Growth hormone producing cells were found prevailing in the primary tumour as well as in secondaries by immunohistochemistry and immunofluorescence which concurred with acromegaly. Many cells produced prolactin. The tumour spreading discontinually in subdural and subarachnoid space was taken for a carcinoma.

Acromegaly↗
PubMed1981

Unusual electron microscopy findings in liver biopsies from patients with viral hepatitis B.

Electron microscopy of 57 needle biopsies from livers of 55 patients with chronic hepatitis, mostly of type B, revealed, in addition to typical hepatitis B virus nucleocapsids in 34 cases, also atypical intranuclear inclusions in 9 biopsies. These inclusions consisted of electron-dense particles similar in size to hepatitis B virus nucleocapsids. The possibility of an involvement of a hepatitis non-A non-B virus is discussed.

Adult↗
PubMed1980

The use of 99Tc-pyrophosphate for imaging and measuring of calcification caused by implanted polymers.

Pyrophosphate labeled with 99Tc was evaluated as an indicator of the calcification which occurs after implantation of polymeric materials in rats. Poly(2-hydroxyethyl methacrylate), both porous and homogeneous, had been implanted. 99Tc pyrophosphate was applied intravenously to rats in intervals from 14 days to 15 months. Scintigraphy, x-ray examination, and histology were carried out. The ratio of specific activity in the capsule around the implant to specific activity in the reference tissue was determined. The cumulation of activity was parallel with the development of calcification as revealed by histology. The method can be used not only in the screening test of new polymeric materials, but also in a quantitative determination of the degree of calcification in general.

Animals↗
PubMed1979

Biological effects of some N-substituted (meth)acrylamides.

This paper reports an investigation of the biological effects of monomers of N-substituted (meth)-acrylamides used in the preparation of polymers suitable for medical purposes. By combining tests carried out on cell cultures and on living animals, we found thpheral nervous system. Tests performed on cell cultures can be used as preliminary and supplementary ones in testing the toxicity of substances on living animals.

Acrylamides↗
PubMed1979

Biological tolerance of copolymers of N-substituted (meth)acrylamides in the test organism.

The mechanical properties of hydrolphilic crosslinked polymers of N-substituted (meth)acrylamides may be improved by copolymerization with N-tertbutylacrylamide [1] so that the mechanical properties of resulting copolymers satisfy requirements on polymers used in medicine. Tests of the biological tolerance of the above copolymers have shown that the latter are completely nontoxic with respect to cell cultures and do not cause any reaction or changes in the subcutaneous implantation into a living organism.

Acrylamides↗
PubMed1979

Angiographic appearance of benign retroperitoneal lymphoma.

The authors report on a quite unusual case of the very rare angiofollicular lymph node hyperplasia (Castleman's tumor). This one appeared as a large retroperitoneal mass. According to the anatomical structure, the X-ray showed it as being obviously malignant.

Adult↗