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Biomedical subjects

L Sprincl

Publications and source records attributed to L Sprincl.

At least 37 records · Page 2Linked to original sources
PubMed1980

The use of 99Tc-pyrophosphate for imaging and measuring of calcification caused by implanted polymers.

Pyrophosphate labeled with 99Tc was evaluated as an indicator of the calcification which occurs after implantation of polymeric materials in rats. Poly(2-hydroxyethyl methacrylate), both porous and homogeneous, had been implanted. 99Tc pyrophosphate was applied intravenously to rats in intervals from 14 days to 15 months. Scintigraphy, x-ray examination, and histology were carried out. The ratio of specific activity in the capsule around the implant to specific activity in the reference tissue was determined. The cumulation of activity was parallel with the development of calcification as revealed by histology. The method can be used not only in the screening test of new polymeric materials, but also in a quantitative determination of the degree of calcification in general.

Animals↗
PubMed1979

Biological effects of some N-substituted (meth)acrylamides.

This paper reports an investigation of the biological effects of monomers of N-substituted (meth)-acrylamides used in the preparation of polymers suitable for medical purposes. By combining tests carried out on cell cultures and on living animals, we found thpheral nervous system. Tests performed on cell cultures can be used as preliminary and supplementary ones in testing the toxicity of substances on living animals.

Acrylamides↗
PubMed1979

Biological tolerance of copolymers of N-substituted (meth)acrylamides in the test organism.

The mechanical properties of hydrolphilic crosslinked polymers of N-substituted (meth)acrylamides may be improved by copolymerization with N-tertbutylacrylamide [1] so that the mechanical properties of resulting copolymers satisfy requirements on polymers used in medicine. Tests of the biological tolerance of the above copolymers have shown that the latter are completely nontoxic with respect to cell cultures and do not cause any reaction or changes in the subcutaneous implantation into a living organism.

Acrylamides↗
PubMed1979

Angiographic appearance of benign retroperitoneal lymphoma.

The authors report on a quite unusual case of the very rare angiofollicular lymph node hyperplasia (Castleman's tumor). This one appeared as a large retroperitoneal mass. According to the anatomical structure, the X-ray showed it as being obviously malignant.

Adult↗
PubMed1977

Biological effects of 2,4-pentadiene-1-ol.

The biological effects of 2,4-pentadiene-1-ol (CH2 = CH--CH = CH--CH2--OH) the starting monomer in the preparation of a biocompatible polymer were studied. The experiments in rats revealed both a high local (oedema, necrosis) and systemic toxicity. Within 5-10 min after dermal application of 0.2 ml the compound evoked intensive hyperaemia of acral parts (ears, snout, paws) and induced severe breathing difficulties which led to death in half of the animals after a single administration. The most evident macroscopic and microscopic pathologic changes were found in the place of application and in the lungs (haemorrhage in alveolae). Both clinical and histological findings indicated that the toxicity is due to an increased permeability of capillaries.

Administration, Topical↗
PubMed1976

New types of synthetic infusion solutions. III. Elimination and retention of poly-[N-(2-hydroxypropyl)methacrylamide] in a test organism.

The elimination and retention of a new, fully synthetic plasma prosthesis of Czechoslovak origin under the working name of Duxon (poly[N-(2-hydroxypropyl)methacrylamide]) was investigated in experiments on rabbits by using a 14C-labeled polymer. Results published earlier on elimination have been confirmed and extended. Retention was examined after repeated application. The effect of molecular weight prevailed both in elimination and in retention. Polymers of lower molecular weights, which possess a good therapeutical effect, are not permanently deposited in the organism.

Acrylic Resins↗
PubMed1976

Biological tolerance of copolymers of 2-hydroxyethyl methacrylate-vinylpyridine.

The healing-in of implants of terpolymer gels having different chemical composition was studied in animals. Histological analysis showed that all polymers under investigation are healed-in in a similar way by encapsulation with collagen fibrous tissue. Neither cancerogenic effect nor calcification were observed within the interval studied.

Acrylic Resins↗
PubMed1976

Mucopolysaccharide complexes in the fibrous tissue surrounding hydrophilic polymers in subcutaneous implantation.

The biocompatibility of three types of hydrophilic poly-(glycol methacrylate) gels--homogeneous, microporous and macroporous--was investigated in an experimental subcutaneous implantation. The occurrence of mucopolysaccharide complexes formed by both hyaluronic acid and chondroitine sulphates was examined in the fibrous tissue which surrounds the implant and penetrates into it in the case of a macroporous polymer. In an early stage of investigation hyaluronic acid prevails, but with proceeding collagenization the chondroitine sulphate part becomes predominant.

Animals↗