Biomedical subjects
Publications and source records attributed to L Strömberg.
By means of a new method with high precision (error 3.1 percent), the maximum torque capacity of an entire long bone from an experimental animal was measured under standardized conditions within 10 minutes after sacrifice of the animal.
The unfavourable effect of the rigid internal fixation plate on the strength (measured as maximum torque capacity) of the diaphyseal bone, with due attention to the importance of the screw holes, has been studied on the femora of 7 dogs. When the plates that had been applied for 7 months without previous osteotomy were removed, a significantly reduced maximum torque capacity was observed, as also a significantly reduced maximum angle of torsion, and a significantly changed distribution of the amount of bone mineral.
Chemical signatures of phenmetrazine hydrochloride were studied by gas chromatography. The inter-batch variations of the signatures were found to be large whereas the intra-batch variations were usually small. The method is used for the tracing of seized phenmetrazine hydrochloride samples to common sources, which in turn may permit further tracing back to chains of illicit distribution of this drug. The applicability of the method to other narcotics is also discussed.
Trace impurities in amphetamine sulphate were studied by a highly sensitive gas chromatographic method. The concentration of these impurities varied considerably between batches whereas the variations within the batches were usually very small. The method is used for the assignment of seizures of amphetamine sulphate to common sources, which in turn may permit chains of illicit distribution of this drug to be traced.
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Adult rabbits were divided into three equal weight-matched groups. Drill holes 2.3 mm in width were drilled through the midshaft of the right femur across both cortices. A sham operation was performed on the left femur and served as a control. Group I was given indomethacin, 5 mg/kg twice daily. Group II was given ibuprofen, 7.5 mg/kg twice daily. Group III was given a placebo solution. Each group was treated for five or eight weeks. The serum levels of indomethacin and ibuprofen were recorded during treatment. After the rabbits were killed the legs were dissected from soft tissue and stored in a freezer. After thawing, the bones were examined for torsional strength. Neither the indomethacin nor the ibuprofen groups regained their torsional strength during the treatment periods, as compared with the controls. Anti-inflammatory drugs probably bring about their effects by acting on the prostaglandin synthesis. Although the effects produced by the drugs are significant, it is still uncertain whether the effects are great enough to influence one's decisions regarding their use.