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L Syrůcek

Publications and source records attributed to L Syrůcek.

47 records · Page 3Linked to original sources
PubMed1969

Hong Kong influenza in Czechoslovakia, 1969: a preliminary surveillance report.

Cases of Hong Kong influenza did not appear in Czechoslovakia until the middle of January 1969, although cases had occurred in neighbouring Poland in December 1968.Altogether 426 strains of A2 influenza virus were identified between the 5th and 22nd weeks of 1969 and their biological and antigenic properties were investigated. The strains isolated were highly sensitive to non-specific inhibitors present in horse, guinea-pig and human sera: in human sera, the inhibitors could be removed by means of receptor-destroying enzyme but not by treatment with KIO(4). The haemagglutinin of the new variant was much less sensitive to a temperature of 56 degrees C-65 degrees C than the former A2 strains. The results of all these investigations, which also included complement-fixation and haemagglutination-inhibition tests, showed that the epidemic was caused by A2 influenza strains antigenically and biologically identical with the A2/Hong Kong/68 strain.Surveillance studies showed that the outbreak started in the north-western part of Bohemia and Moravia and spread to the south-east. The rural areas were much less affected than the industrial and densely populated areas. The number of deaths due to influenza and pneumonia was only slightly higher than the seasonal average, probably because of the mild clinical course of the disease.

Adolescent↗
PubMed1965

Comparative trial of live measles vaccines in Czechoslovakia.

The study reported in this article was conducted under the auspices of WHO as part of the Organization's programme on measles vaccination.In the spring of 1964, 416 children aged between 8 months and 3 years were inoculated with one or another of the following agents: Enders Edmonston B vaccine (alone or with gamma-globulin), Schwarz vaccine, Beckenham 20 vaccine, Milovanović vaccine, and a placebo.Seroconversion rates ranged from 91% to 100%, which indicates that the vaccines tested were highly immunogenic. The incidence of reactions was low, and from the clinical point of view acceptable. Clinical comparison of the reactions provoked by the different vaccines showed that the lowest rate was in the groups given Schwarz vaccine and Enders Edmonston B plus gamma-globulin, and the highest in the group given Beckenham 20 vaccine. However, the greater frequency of reactions observed with Beckenham 20 vaccine might have been due to the high dose given in the first stage of the trial.Complications were observed in 10 children, of whom four were in the placebo group. In three of the remaining cases a causal connexion with the vaccine could not be excluded with certainty.

Child, Preschool↗
PubMedDate not supplied

Antibody response in humans after administration of whole-virion and split vaccine prepared from two different influenza A/swine viruses.

Previous findings with sera of several different animal species had indicated a close antigenic similarity between the X53 recombinant (possessing both surface antigens of A/Swine/New Jersey/76 virus) and the A/Swine/Ann Arbor/31 (AA) virus (1). Since the latter virus grows much better in chick embryos than the former, we examined the possibility of using the Ann Arbor virus instead of X53 for inactivated vaccine production. The present paper describes our findings in sera of subjects immunized with either whole-virus or split vaccine prepared from AA virus.

Adolescent↗