Biomedical subjects

L Tedesco

Publications and source records attributed to L Tedesco.

4 recordsLinked to original sources

PubMed1992

Biologic relevance of elevated red cell adenosine deaminase activity in myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria.

Red cell adenosine deaminase (ADA-RBC) activity in patients with myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria is significantly increased compared to that observed in normal controls. ADA-RBC activity is not related to fetal hemoglobin concentration, but it is significantly correlated with hemoglobin concentration at diagnosis and with the degree of morphologic dysplasia in the erythroid lineage. The results of our study suggest that the observed enzymatic abnormality may constitute a non-specific manifestation of the stem cell alteration that determines these disorders.

Adenosine Deaminase↗

PubMed1992

DentLE. The dental learning environment: a prototype.

The State University of New York at Buffalo School of Dental Medicine was awarded a 'Model Curriculum' grant through the USPHS Bureau of Health Professions Education. The award was provided in support of the School's ongoing effort to design a 'model electronic curriculum' for the health professions. The project's development is described from its grounding in critical thinking and problem solving to a discussion of its features including the organization of its knowledge base, the layout of its computer-based oral health record, and its navigation features.

Computer-Assisted Instruction↗

PubMed1986

Phenotypically immature IgG-bearing B cells in patients with hypogammaglobulinemia.

We investigated the prevalence of phenotypically immature IgG B cells (i.e., coexpressing surface IgG and IgM) in the peripheral blood of 12 patients with hypogammaglobulinemia and in normal individuals. Patients had ataxia-telangiectasia (N = 1), hyper-IgM combined immunodeficiency (N = 1), or common variable immunodeficiency (CVI). IgG/IgM-positive B cells were evaluated by two-color immunofluorescence using fluorescein- or rhodamine-conjugated goat antiserum; to minimize artifacts due to in vivo cytophilic binding of autologous IgG, cell-bound cytophilic Ig were eluted at pH 4 and Fc receptors were blocked by heat-aggregated rabbit IgG before fluorescent staining. All patients, except two with late-onset CVI, had markedly increased proportions of double-stained IgG B cells (56 to 100% of IgG-bearing B cells) in comparison with normal individuals (11 to 33%).

Adult↗

PubMedDate not supplied

[Analysis of the use of fluoridated dentifrices in Curitiba].

The use of fluoride dentifrices in Curitiba (Brazil) was studied. The scholarity and socio-economical levels of the population were related to the use of fluoride dentifrices. The sample was composed of 155 persons, men and women. The results showed that 96.8% used dentifrices, but only 36.2% used fluoride dentifrices. The use of fluoride dentifrices was more significant among the higher socioeconomical and school levels.

Brazil↗