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Biomedical subjects

L V Serova

Publications and source records attributed to L V Serova.

At least 19 recordsLinked to original sources
PubMed1998

[Effect of weightlessness on rats endocrine system development].

The histological structure of the brain and spinal cord, visual, olfactory, auditory and vestibular analysers, and endocrine organs (epiphysis, hypophysis, thyroid and parathyroid glands) were investigated in newborn rats delivered by females who had been exposed to weightlessness a half of the pregnancy period. Analysers of the flight animals did not have any marked deviations from the norm. Loci of neurone degeneration resembling porencephaly but less massive were revealed in various brain portions (cortex, hypocampus, metencephalon, spinal cord) of the infant rats developed in space flight. Endocrine studies showed accelerated differentiation of the thyroid cells secreting thyroid hormones, C-cells, and parathyroid cells in most of the infant rats of the flight group. The test animals reduced the size of epiphysis and the number of pinealocytes. Adenohypophysis was found to be smaller with altered spatial distribution of the trabecular system. The changes look quite impressive but do not threaten viability of the animals.

Animals↗
PubMed1996

[Adaptive potentials of mammals under conditions of weightlessness].

Review and analysis of experiments with Wistar rats in microgravity allows to deduce that compensatory-adaptive potentials of mammals in space flight lasting up to 1/50th of their life span suffice for rapid elimination of space-induced metabolic and structural alterations on return to Earth, maintenance of adequate reactions to acute and chronic stresses in the post-flight period, demonstration of a stereotype of pre-flight elaborated conditional reflexes and pregnancy dominant, normal reproductive function and life span. Consideration is given to individual differences in body responses to the micro-g environment. A conclusion is made to the effect that the role of individual stamina and reactivity will be gaining in importance with increasing duration of space flights.

Adaptation, Physiological↗
PubMed1996

[Effect of weightlessness on the mother-fetus system (results of embryological experiment NIH-R1 abroad the "Space Shuttle"].

Female rats were exposed to weightlessness in the mid-deck of US "Space Shuttle" in the period between days 9 to 20 of pregnancy and examined on Earth post flight. No significant structural anomalies threatening the life and normal development were found in newborn rats carried by mothers under the conditions of weightless exposures. Water, Na, K, Ca, Fe and Cu contents in fetal and placental tissues of the flight animals were not changed. Differences between the flight and ground-based synchronous controls, or the rates of formation of the fetal skeleton were not revealed. Comparison of these data with results of the experiment aboard biosatellite "Cosmos 1514" in which female rats stayed in weightlessness from day 13 to 18 of pregnancy indicates that the two-fold increase of space flight duration did not add changes in the state of fetuses.

Animals↗
PubMed1995

[The redistribution of calcium ions and organic substances in pregnant rats under extreme conditions].

It was found that under water deprivation the liver, spleen, white and brown fat decreased in weight in rats whereas the weight of the heart, kidneys and uterus with fetuses did not differ from the control. In pregnant rats, water deprivation led to involution of thymus and hypertrophy of adrenals, decrease in the calcium ions content in the liver and kidney and reducing of the liver and some other organs weight. A similar picture was observed during space flight in pregnant rats. The data obtained suggest a redistribution of organic and inorganic substances under water deprivation.

Animals↗
PubMed1995

[Water-salt homeostasis in rats during space flight].

The paper generalized the results of s series of experiments aimed at studying liquid and electrolytes contents in various organs and tissues of rats following 3-week space flights (SF). The results ascertain high reliability of the water-salt homeostasis maintaining system which ensures stable water and electrolytes amounts in the majority of animal tissues in SF. The following alterations appear to be of greatest significance: deduced potassium levels in the heart ventricle tissues in male rats after short-duration (7-9 d) exposure in SF, zero-g-induced degradation of the body ability to bind potassium at injection of isotonic solution KCl into the stomach; redistribution of potassium ions between mother and developing fetuses in space experiments with pregnant animals. Simulated experiments showed that similar shifting of potassium ions in the mother-fetus system may be due not to weightlessness exclusively but other impacts, i.e. they are not specific.

Animals↗
PubMed1991

Decrease in the number of progenitors of erythrocytes (BFUe, CFUe), granulocytes and macrophages (GM-CFC) in bone marrow of rats after a 14-day flight onboard the Cosmos-2044 Biosatellite.

A decrease in the number of progenitors of erythrocytes (BFUe, CFUe) and of granulocytes and macrophages (GM-CFC) in bone marrow was found in rats exposed to microgravitation during a 14-day flight onboard the Cosmos-2044 biosatellite when compared to control rats maintained under conditions of gravitation on the ground. The number of progenitors of both lineages of haemopoiesis was also decreased in synchronous control rats, thus suggesting that the pool of progenitors is influenced also by the action of the nonspecific space flight factors.

Animals↗
PubMed1990

Effects of spaceflight on the spermatogonial population of rat seminiferous epithelium.

Testes from rats flown on Cosmos 1887 were compared with vivarium control and synchronous control samples. The mean weights of flight testes, normalized for weight per 100 g, were 6.4% less when compared with the vivarium controls. Counts of spermatogonia from tissue sections (seminiferous tubules in maturation stage 6) from five animals in each group revealed 4% fewer spermatogonia in flight testes compared with synchronous controls and 11% fewer spermatogonia in flight samples compared with vivarium controls.

Animals↗
PubMed1990

Decrease in the number of progenitors of fibroblasts (CFUf) in bone marrow of rats after a 14-day flight onboard the Cosmos-2044 biosatellite.

A decrease in the number of progenitors of fibroblasts (CFUf) was found in bone marrow of rats that underwent a 14-day flight in the state of weightlessness onboard the Cosmos-2044 biosatellite, immediately after flight, when compared with rats maintained in control conditions of terrestrial gravitation. These changes may be explained by the action of specific factors of microgravitation.

Animals↗
PubMed1985

Changes in the number of haemopoietic stem cells (CFUs) in bone marrow and spleens of pregnant rats after a short space flight onboard the Cosmos-1514 biosatellite.

After a 5-day stay in a state of weightlessness onboard a biosatellite Cosmos-1514 the pregnant rats exhibited a decrease in the number of haemopoietic stem cells (CFUs) in bone marrow and spleens on the recovery day after the space flight as compared to rats kept in the vivarium under usual conditions. The different changes in the concentration of CFUs in the bone marrow and spleens of flight and synchronous control rats indicate that the extent of the decrease in CFUs pool in the spleens of flight rats was significantly influenced by the action of non-specific flight factors.

Animals↗