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Biomedical subjects

L Walsh

Publications and source records attributed to L Walsh.

47 records · Page 3Linked to original sources
PubMed1975

Functional organization of the rat amygdala with respect to avoidance behavior.

Bilateral electrolytic lesions in the periamygdaloid piriform cortex of female albino rats produced marked disruptive effects on the acquisition of active avoidance responses in a 1-way as well as a 2-way test situation, significantly impaired passive avoidance behavior, and inhibited feeding in a novel environment. Lesions in each of the 6 major subdivisions of the amygdala (cortical, medial, central, intercalated, lateral, and basolateral nuclei) consistently produced facilitatory effects on active avoidance behavior in 1-way as 2-way situations. Passive avoidance behavior was impaired in animals with lesions in the central, intercalated, and basolateral nuclei. Damage to the anterior amygdaloid area or the the nuclei of the lateral olfactory tract did not reliably affect active or passive avoidance behavior.

Agonistic Behavior↗
PubMedDate not supplied

A comprehensive educational program improves clinical outcome measures in inner-city patients with asthma.

BACKGROUND: Despite improved understanding of the pathophysiology of asthma, morbidity and mortality continue to rise, with disproportionate increases occurring among urban, indigent minorities. New approaches in the management of asthma are therefore necessary to reverse these dramatic and costly trends. OBJECTIVE: To determine if patients who are admitted to the hospital with acute asthma and receive inpatient education will have improved outpatient follow-up and clinical outcome measures compared with those receiving conventional care. METHODS: Patients enrolled in the study had a primary admission diagnosis of asthma and were between ages 18 and 45 years. Exclusion criteria included comorbid disease, inability to speak English, absence of a telephone in the primary residence, or pregnancy. Seventy-seven patients admitted from the emergency department with asthma were randomized to either the inpatient educational program (IEP) or routine care (control group). Patients in the IEP received asthma education, bedside spirometry, a telephone call 24 hours after discharge, and scheduled follow-up in an outpatient asthma program within 1 week of discharge. Those individuals randomized to the routine management group received conventional inpatient asthma care and routine follow-up. RESULTS: The patients enrolled in the IEP had a markedly higher follow-up rate compared with outpatient appointments (60% vs. 27%; P = .01) and significantly fewer emergency department visits (P = .04) and hospitalizations (P = .04) for asthma in the 6 months following IEP intervention, as compared with control patients. This represented a substantial cost savings to the managed care organization. CONCLUSION: Our study suggests that an IEP in the treatment of indigent, inner-city patients hospitalized with asthma reduces the need for subsequent emergent care and improves outpatient follow-up in a cost-effective manner.

Acute Disease↗
PubMedDate not supplied

Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm.

Sero-epidemiological data are presented in which antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides has been investigated in a community in Papua New Guinea infected predominantly with N. americanus. It is our contention that the antigenic cross-reactivity which undoubtedly exists between these species accounted for (i) a peak in antibody levels against N. americanus in 10-13 years old children (driven by infection with A. lumbricoides), and (ii) the maintenance of apparent antibody levels against A. lumbricoides in older age groups (driven by infection with N. americanus in the absence of overt infection with A. lumbricoides). Cross-reactivity was analysed further, and apparently N. americanus-specific epitopes identified, by immunoblotting. These observations could have considerable bearing on the interpretation of data from sero-epidemiological studies which failed to take account of concurrent infection with these parasites.

Adolescent↗
PubMedDate not supplied

Home-based services by nurse-midwives. Sample data from phase II of nurse-midwifery care to vulnerable populations in the United States.

This article presents prospective data from Phase II of Nurse-Midwifery Care to Vulnerable Populations in the United States, about home-based health care, including home birth, provided to women and infants by CNMs and the type of practice in which these services are provided. Forty-one certified nurse-midwives collected data on 1,739 client visits, of which 234 occurred in the home. The results indicate that the majority of home visits occur within a practice setting that includes more traditional modes of service and that a proportion of women choose home as the place for health care.

Adolescent↗
PubMedDate not supplied

Obsessive-compulsive disorder and fear of AIDS contamination in childhood.

Two cases of obsessive-compulsive disorder (OCD) in prepubertal children are described in which the predominant obsessive ruminations relate to fear of acquired immune deficiency (AIDS) contamination. The findings in these cases are discussed in relation to known demographic and clinical profiles of OCD in children and adolescents. Fear of AIDS contamination in childhood OCD may reflect the effect of the current emphasis on AIDS in potentially vulnerable children with environmental influences giving the symptoms their specific content.

Acquired Immunodeficiency Syndrome↗