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Biomedical subjects

L Wilhelmsson

Publications and source records attributed to L Wilhelmsson.

24 records · Page 2Linked to original sources
PubMed1979

Prostaglandin-like substances in Propionibacterium acnes. III. Differential contractile effects on smooth muscle layers of the human utero-tubal junction.

The biological activity of a lipid fraction extracted from P. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. The bioassay experiments support the concept that prostaglandin-like substances (PLS) occur in P. acnes. However, in the bioassay system used, the effect of PLS was different from that of PGF2 alpha and PGI2 but similar, although not identical, to that of arachidonic acid and PGE2.

Epoprostenol↗
PubMed1979

The action of prostacyclin (PGI2) on the contractility of the isolated circular and longitudinal muscle layers of the human oviduct.

Small strips from the circular and longitudinal muscle layers of the ampullary-isthmic portion of the human oviduct were mounted in organ chambers for recording of their spontaneous contractility. Concentrations in the order of 1-300 ng/ml of PGI2 were tested and compared with similar concentrations of PGE2 and PGF2 alpha. It was found that PGI2 contracted the longitudinal muscle layer in the same manner as did PGE2. The spontaneous activity of the circular layer was markedly suppressed by PGE2 but only moderately inhibited by PGI2 even at high concentrations.

Adult↗
PubMed1979

Some clinical and theoretical aspects on prostaglandins in obstetrics and gynecology.

The present article discusses two aspects on prostaglandins, both related to the control of uterine contractility. One concerns a clinical problem, induction of abortion, and argues in favor of systemic instead of intrauterine administration of prostaglandins and the choice of E instead of F analogues. The other relates to the stimulatory effect on the myometrium of some recently detected endogenous prostaglandins. The discussion regarding the endogenous control of myometrial contractility has so far exclusively been focused upon the classical prostaglandins. It is, however, felt that substances like PGH2, PGI2 and thromboxane A2 may play a significant role in the regulation of uterine activity.

Abortion, Induced↗
PubMed1979

Prostaglandins and the contractile function of the human oviductal ampulla.

Millimeter-wide muscle strips were prepared from the circular and longitudinal musculature of the oviductal ampulla of fertile women. These specimens were mounted in organ baths for isometric recording of contractile activity. The two types of strips exhibited similar rhythmic spontaneous activity which was found to be present in all phases of the menstrual cycle. Prostaglandin E2 (PGE2) caused an inhibition of contractile activity in both the circular and longitudinal layers, whereas PGF2 alpha induced a marked excitatory response in the specimens. Administration of prostacyclin (PGI2) also elicited an excitatory effect although much less pronounced that that of PGF2 alpha. Pretreatment with ETA, a blocker of endogenous prostaglandin synthesis, abolished the spontaneous contractile activity in a concentration-dependent manner. It is concluded that the ampullary portion of the human oviduct possesses pharmacological properties which differ in certain important respects from those of the isthmus. A shift in the tissue levels of endogenous prostaglandin levels may occur in sequence with ovulation and the pattern of the prostaglandins synthesized seems to be appropriate for the contractile function of the various tubal segments during ovum transport in women.

5,8,11,14-Eicosatetraynoic Acid↗