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L Zimnoch

Publications and source records attributed to L Zimnoch.

90 records · Page 5Linked to original sources
PubMedDate not supplied

[A case of malignant extrameningeal meningioma of the spinal canal with multiple metastases in a 17-year-old patient. Clinical and morphologic studies].

A clinical description and pathological findings are reported in a case of extrameningeal, angiogenic malignant meningioma of the vertebral canal (Th7-Th11) in a patient aged 17 years. Clinical picture was that of transverse myelitis at the Th9 level, with spastic paraparesis, funicular loss of all sensory functions and sphincter disturbances. The authors suppose that the used combined treatment (chemotherapy and radiotherapy, surgery) improved greatly the health state inhibiting the spread of metastases and prolonged survival to 3 years. Autopsy demonstrated recurrence of he tumour in the vertebral canal and numerous metastases to the brain, lungs, liver, bones and pancreas.

Adolescent↗
PubMedDate not supplied

[Encephalomyelitis of atypical course probably caused by Echovirus 7].

The authors report a cases of encephalomyelytis caused probably by ECHO7 virus which was isolated from the cerebrospinal fluid after 45 days of disease. During 120 days 4 relapses of the disease were observed associated with severe general and neurological signs and cerebral coma which ultimately was the cause of death.

Acute Disease↗
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[Regeneration of peripheral nerves by muscle autografts in rats. I. Morphological and morphometrical evaluation].

Regeneration of myelinated axons with 1 cm freeze-thawed skeletal muscle autografts was compared with nerve grafts in the rats. Regeneration was assessed histologically and morphometrically in the grafts and distal nerve stumps. Recovery of axon numbers and fibre diameters in distal nerve stumps was similar in the two kinds of grafts 6 months after operation. These observations suggest that freeze-thawed autogenous muscle grafts might be used in the repair of peripheral nerves.

Animals↗
PubMedDate not supplied

[Study of the effect of biogonadyl on the regeneration of the rat's sciatic nerve].

Using electroneurographic and morphological methods the effect of Biogonadyl on the regeneration of sectioned and the sutured sciatic nerves was evaluated. The analysis of conduction parameters in the sciatic nerves during the 6-week experiment, although the results obtained were not statistically significant, suggests a beneficial effect of Biogonadyl upon regeneration processes in the nerves. Morphological and morphometric studies have demonstrated that Biogonadyl statistically significantly accelerated axon growth in the distal part of sciatic nerves. It did not, however, influence the processes of their maturation.

Animals↗
PubMedDate not supplied

Immunohistochemical demonstration of fibrin II in gastric cancer tissue.

Immunohistochemistry was applied to AMeX-fixed sections of twelve cases of gastric carcinoma obtained at surgical resection to explore the occurrence and distribution of fibrin deposits in situ. Fibrinogen was distributed in abundance throughout perivascular zones and in the connective tissue of the tumor stroma. Fibrin II (des-fibrinopeptide B-type fibrin) was easily identified in a direct apposition to the surface membranes of viable carcinoma cells, predominantly at the host-tumor interface and in the regions immediately adjacent to the zones of angiogenesis. Further studies are required to identify the triggers of the coagulation reactions as well as fibrinolytic system components in the gastric cancer tissue.

Carcinoma↗
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[Intracranial chordomas; histochemical and immunohistochemical examinations].

Chordoma is one of rare intracranial neoplasms (0.2-0.5%). Apart from classic chordoma in 1973 r. Heffelfinger and al. separated chondroid chordoma which showed better prognosis. We studied 4 classic and 3 chondroid intracranial chordomas. All tumours contained chondroitine sulfate and keratan sulfate and showed positive immunohistochemical reactions to cytokeratin, S-100 protein and vimentin, supporting the concept of common origin of both types of chordomas. Immunohistochemical studies of PCNA and Ki-67 antigen and staining AgNOR's did not show significant differences in the proliferative activity between both types chordomas what attests to biological malignancy.

Adult↗
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Pathomorphology of lungs and heart in experimental prolonged hypoxia.

The authors carried out morphological examinations of lungs and heart in 20 days with prolonged hypoxia caused by surgical subglottic stenosis of the trachea by 50%. The studies showed that 30 and 60 days after the onset of hypoxia changes such as emphysema and chronic bronchitis developed in the lungs showing an increasing tendency, while in the myocardium microgranular disintegration and fatty infiltration of muscle fibres with simultaneous disappearance of glycogen was seen in the first period-after 30 days - while later, after 60 days fibrosis developed.

Animals↗
PubMedDate not supplied

AgNORs in duct epithelial lesions in chronic pancreatitis and in pancreas cancer cells.

BACKGROUND/AIMS: Argyrophilic nucleolar organizer regions (AgNORs) reflect the proliferative activity of cells. Since the majority of pancreatic cancers are ductal carcinomas, the aim of the study was to determine the AgNORs expression of potential pre-neoplastic ductal epithelial lesions in advanced chronic pancreatitis compared with pancreatic cancer cells. METHODOLOGY: Histological preparations obtained from 24 patients with chronic pancreatitis and 16 patients with pancreatic cancer were used to estimate the number of AgNORs per nucleus. Four types of AgNORs were distinguished and histograms with cell percentage of each type were performed for all forms of epithelial anomalies. RESULTS: In simple hyperplasia, squamous and mucous metaplasia the number of AgNORs ranged from 1.92 to 2.23; type I was predominant. In papillary hyperplasia, dysplasia and in situ carcinoma the number ranged from 2.98 to 3.34, with a predominance of type II-IV. In invasive carcinoma the number was 4.29 and 74% of cells were of type II-IV. CONCLUSIONS: Both counts of AgNORs and the percentage of type II-IV cells showed a gradual increase from simple hyperplasia through papillary hyperplasia and dysplasia to invasive carcinoma which in this respect differs significantly from all forms of the epithelial anomalies examined.

Carcinoma in Situ↗
PubMedDate not supplied

[Expression of p53 protein and proliferative activity in multiform glioblastoma].

The aim of the study of 41 multiform glioblastomas was the analysis of p53-protein immunoreactivity in neoplastic cells and evaluation of relationship of this biologic marker to tumour proliferation activity. Positive p53 expression was observed in 24 (58.5%) tumours, the negative one in 17 tumours (41.5%). Proliferation indexes of PCNA, anti-Ki6 and AgNORs showed high values in the multiform glioblastoma p53 positive group, but without statistical differences in comparison with the group of p53-negative glioblastomas. Significant differences were observed in survival time of patients with p53 positive tumours in comparison with p53-negative ones. In 15 patients with p53-positive multiform glioblastomas survival time was less than 6 months (62.5%) on the contrary with only 4 patients with similar survival time in p53-negative glioblastoma group (23.5%). Our results suggest that p53 expression in multiform glioblastoma cells, generally considered as the indirect index of p53 suppressor gene, reflects aggressive stadium of neoplastic disease and significantly worsens the prognosis.

Adult↗