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Biomedical subjects

M A Cheĭdo

Publications and source records attributed to M A Cheĭdo.

At least 19 recordsLinked to original sources
PubMed2006

[Differential contribution of dopamine D1 and D2 receptors in the mu-opioidergic immunomodulation].

The study has shown that activation of mu-opioid receptors by a highly selective agonist DAGO (100 microg/kg) results in a significant increase of the immune response to antigen (SRBC, 5% 10(8)) in CBA mice. Haloperidol (2 mg/kg), a selective antagonist of the postsynaptic dopamine (DA) receptors, prevented immunostimulating effect of DAGO. In contrast, selective D1--antagonist SCH 23390 (1 mg/kg) did not affect on DAGO-induced enhancing of immune reactivity. At the same time, the blockade of both types of DA receptors (D1 and D2) caused similar immunosuppressing effects. These data suggest a possible differential role for D1 and D2 receptors in mu-opioidergic immunomodulation.

Analgesics, Opioid↗
PubMed2006

[Effect of the activation and blockade of D2 dopamine receptors on the immune response in mice with different types of social behavior].

Activation of D2 dopamine receptors with a selective agonist quinpirol in C57BL/6J mice was found to induce increase in the immune response regardless of the initial psychoemotional state of animals, e. g. in aggressive mice, submissive mice, and mice without victory or defeat experience (control). However, the immune response level in aggressive and submissive mice was significantly higher than that of control animals. At the same time, the blockade of D2 dopamine receptors with haloperidol suppressed immunogenesis in aggressive and control mice, whereas the immune reactions in submissive mice were unchanged. Thus, the effect of activation and blockade of D2 dopamine receptors on immune function is dependent on the initial psychoemotional status of animals which to a greater extent might be provided by the neuromediator pattern of the brain and activity of DA receptors.

Animals↗
PubMed2005

[The role of D1 and D2 dopamine receptors of the rat nucleus accumbens in immunostimulation].

The analysis of the immune response changes in Wistar rats has shown that bilateral electrolytic lesions of the nucleus accumbens characterized by a high density of D1 an D2 dopamine (DA) receptors resulted in a decrease of the immune response to SRBC. Administration of selective agonists of D1 and D2 DA receptors to sham-operated animal: 20 mg/kg of SKF 38393 or 1.0 mg/kg of quinpirol, respectively, produced significant enhancement of plaque- and rosette-formation. However, the immune response level in the damaged rats did not increase following quinpirol administration, but was maintained at control values, rather. At the same time, activation of D1 DA receptors in rats with destructed nucleus accumbens did not affect the immune response level as compared to that of sham-operated animals receiving SKF 38393. The data obtained give evidence of involvement of D2 DA receptors of the nucleus accumbens in immunomodulation, although D2 DA receptors of other brain structures may also contribute to this process. D1 DA receptors of this localization seem not to play any important role in the immune response control.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed2004

[Contribution of D2 dopamine receptors of the rat dorsolateral caudate nucleus to immunomodulation].

The analysis of the immune response changes in Wistar rats under activation or blockade of D2 DA receptors has shown that electrolytic lesion of the dorsolateral caudate nucleus characterized by a high density of D2 DA receptors resulted in a decrease of the immune response to SRBC. At the same time, in rats with similar lesion stimulation of the immune reactions caused by a selective D2 agonist guinpirol (1.0 mg/kg) did not develop completely. Administration of haloperidol (2.0 mg/kg), the immune-inhibitory effect of which is associated with increasing serotoninergic system activity, to rats with impaired dorso-lateral caudate nucleus did not produce more expressed immunosuppression. However, the level of the immune response in sham-operated rats receiving haloperidol was significantly lower than that of animal with the destructed nucleus caudatus. Considering that qunmpirol-induced immunostimulation is related to the selective activation of the DA-ergic brain system, it is concluded that D2 DA receptors of the nucleus caudatus are involved in the mechanisms of immunostimulation, although D2 DA receptors of other brain structures may also impact this process.

Adjuvants, Immunologic↗
PubMed2002

[Activation of dopaminergic system stimulates an immune response in mice with opposite type of behaviour].

It was shown that activation of dopaminergic (Daergic) system induced an increase of the immune responsiveness independent of the CBA mice behaviour typeanimals without experience of victories and defeats (control), with aggression and submission. Administration of SKF-38393, a selective agonist of DA D1-receptors, resulted in enhanced immune response as tested by plaque-forming cells and rosette-forming cells number. Similar immunostimulation was observed after injection of p-chlorophenylalanine realizing its influence on the immune response through DA D2-receptors as shown by us elsewhere. It was suggested that activation of Da-ergic system produces a new neurochemical pattern (Daergic neurochemical set) which are responsible for character and intensity changes of the immune response in mice with alternative form of social behaviour.

Aggression↗
PubMed2000

[Participation of the rat caudate nucleus in the immunostimulating effect of DAGO].

The data obtained suggest that administration of the DAGO increased the number of plaque- and rosette-forming cells after immunisation with the sheep red blood cells in the sham-operated Wistar rats. Following destruction of the caudate nucleus, the DAGO administration prevented the immune activation. Bilateral destruction of the caudate nucleus resulted in a considerable inhibition of the immune response as compared with the control rats. Thereupon the caudate nucleus seems to be involved in realisation of the DAGO-induced immune activation.

Adjuvants, Immunologic↗
PubMed1998

[Effect of opioid peptides on immunomodulation].

Activation of the opioid receptors by delta-agonist DSLET and by kappa-agonist rimorphin led to a significant inhibition of plaque-forming and rosette-forming cells in the CBA mice. On the other hand, mu-agonist DAGO stimulated the immune response on the 4th and 5th days after immunization with SRBC (5 x 10(8)). Lesion of the hypothalamo-hypophyseal connection prevented immuno-stimulating as well as immuno-depressive effects. The latter seems to be due to an interaction with the serotoninergic system, whereas immuno-stimulating effect involves the dopaminergic system.

Animals↗
PubMed1998

[The neurochemical set of the brain--an extra-immune mechanism of psychoneuroimmunomodulation].

The present study provides evidence for involvement of brain neurotransmitters in the control of an immune response. The extra-immune mechanism of immunomodulation is considered by analyzing drug-induced changes in the brain neurotransmitter systems, brain destruction, altered activity of brain regions due to psychoemotional stress, including mental disease. It is suggested that the pattern of neurotransmitter activity with its prevalence in certain brain regions determines the neurochemical set-up of the brain for psychoneuroimmunomodulation, i.e. its extra-immune mechanism.

Animals↗
PubMed1993

[The participation of the delta opioid receptors in immunomodulation].

The delta-receptors agonist DSLET inhibited immune responses in the CBA mice. The immunosuppression was shown to be due to an interaction with the serotoninergic system. No immunostimulating effect of the delta-opioid receptors antagonist ICI 174,864 occurred in the animals with dissection of the pituitary stalk. The immunostimulation was shown to be realised via the thymus and prevented by a preliminary haloperidol blockade of the D-2 dopaminergic receptors. The cerebral delta-opioid receptors seem to participate in neuro-immunomodulation through the interaction with the serotonin and dopamine neurotransmitter systems.

Animals↗
PubMed1993

[The normalization of the immune response in old stressed mice by apomorphine].

It has been shown that the immune reactivity of old C57BL/6 mice aged 24-27 months immunized with sheep red blood cells (5 x 10(8)) was decreased as compared to young mice (2-3 months). Activation of the dopaminergic system by the agonist of dopamine postsynaptic receptors apomorphine resulted in normalization of an immune response in old mice. Injection of apomorphine also prevented the immunosuppression observed in old mice, which was induced by immobilization stress (3.5 hours on the back). Immune response level of these animals approached that of young nonstressed animals. It was suggested that disturbance of the mechanisms of psychoneuroimmunomodulation in old and stressed animals could be prevented by changing the neurochemical pattern of the brain.

Aging↗
PubMed1990

[Immunostimulating effect of D2 dopamine receptor agonist quinpirole].

Immunostimulating activity of specific postsynaptic D2 receptor agonist quinpirole (Ly 171555) was studied in CBA mice. The drug was administered intraperitoneally in a dose of 1 mg/kg 30 min before the immunization with SRBC (5 x 10(8)). Considerable stimulation of rosette- and plaque-forming cell number was observed at the early stage (3-d day) and at more late stage of the immune response (5-th day). The increase of rosette- and plaque-forming cell number was provided by IgM-reaction enhancement.

Adjuvants, Immunologic↗
PubMed1990

[Increase of the number of bone marrow T-suppressor cells under inhibition of immunogenesis during changes of the activity of the neuromediator system].

Increase of serotoninergic system activity and blockade of dopaminergic system activity led to the change of T- and B-lymphocyte distribution in immunocompetent organs of non-immunized animals. Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP. Role of bone marrow in neuro-immunomodulation is discussed.

1-Naphthylamine↗
PubMed1987

[Effect of propranolol on immunogenesis and its mode of action].

Administration of beta-blocking agent propranolol (1 or 10 mg/kg) 30 and 60 min prior to immunization with sheep red blood cells enhanced the immune response in CBA mice. The activating effect of propranolol upon immunogenesis can be characterized as peripheral since it is preserved after removal of thymus. Beta-adrenergic mechanisms do not participate in immunomodulating action of serotoninergic and dopaminergic systems.

Adjuvants, Immunologic↗
PubMed1987

[Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine].

The role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-HT2 receptors. It was shown that cyproheptadine administration to CBA mice stimulated the immune response, which was dopamine-dependent and was realized via thymus. With the pituitary stalk destruction, the stimulatory effect of cyproheptadine was not observed, which suggests the participation of 5-HT2 brain receptors in immunogenesis.

Adjuvants, Immunologic↗