Role of perineuritis in the atonic dilated bilharzial ureter.
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Biomedical subjects
Publications and source records attributed to M A Ghoneim.
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The different methods utilized for measurement of urethral resistance were critically reviewed. Using dogs, experiments were done to standardize the pressure profile measurement. A catheter with eight side holes measureing 0.34 mm. each was found to give the best results. The various parameters which can influence the procedure were analyzed. Strict specifications are proposed to be utilized for such a procedure.
Using female dogs, changes in the urethral pressure profile in response to vesical distension were studied. It was noted that during the collecting phase there was an increase in the amplitude of the profile tracing. These experiments revealed that this increase is not mediated through an autonomic reflex and does not reflect a significant enhancement of alpha-adrenergic activity. These changes are mainly due to increased tension of the urethral muscle, secondly to detrusor stretch.
The influence of vesical distension of the urethral pressure profile was studied in female dogs, using a model in which the bladder and urethra were separated. There was a reduction in the urethral resistance involving its smooth and striated muscle components. This reduction was completely blocked by ganglion blocking agents. Atropine did not influence these changes. Propranolol could only partially block this reflex. The other possible mechanisms that could be involved were discussed.
The different methods used for the measurement of urethral resistance were critically reviewed. Experimental studies were carried out to standardize pressure profile measurements. A catheter with 8 side holes was found to give the best results. The various parameters which can influence the measure were studied. Strict specifications of the procedure are proposed.
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