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Biomedical subjects

M A Limouzin-Lamothe

Publications and source records attributed to M A Limouzin-Lamothe.

5 recordsLinked to original sources

What women want from hormone replacement therapy: results of an international survey.

OBJECTIVES: To find out what women in France, Germany and the UK want from hormone replacement therapy (HRT). METHODS: A questionnaire sent to almost 2000 women in France, Germany and the UK followed up by more detailed interviews with 100 women from each country. RESULTS: From the questionnaire sent to 1871 women aged 48-55 years in France, Germany and the UK, it was found that 72% had not used HRT. The main reason for this seemed to be the prescribing physician who did not mention or recommend HRT. Some cultural differences were apparent. For example, in the UK 10% of the women did not use HRT because of perceived contraindications while the corresponding figures in France and Germany were 20% and 23%, respectively. Fear of side-effects was most common in Germany (20%), followed by the UK (14%) and much less in France (8%). In the detailed interviews with 100 women from each country, based on their menopausal status and the fact that they had received HRT, it was found that the main motivating factor was a desire to avoid the effects of ageing and prevent osteoporosis. In spite of their expectations being largely met, about one-third of the women sampled stopped taking HRT, mainly due to a dislike of breakthrough bleeding. CONCLUSIONS: The women who took HRT generally found it a positive experience and women who did use it derived considerable benefit. However, the main determinant whether HRT was used or not was the attitude of the patient's physician.

Aging

Quality of life after the menopause: influence of hormonal replacement therapy.

OBJECTIVE: Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life. STUDY DESIGN: A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verapipride) was performed. Analysis was by intention to treat. RESULTS: In 499 postmenopausal women with moderate and severe symptoms enrolled by 101 physicians, hormone replacement therapy was superior to symptomatic treatment on all assessments of quality of life and clinical efficacy. The effects were independent of the incidence of hot flushes. CONCLUSION: The effect of hormone replacement therapy on the quality of life of postmenopausal women was significantly superior to symptomatic treatment.

Administration, Cutaneous

[Changes in blood cell counts and coagulation factors during labor and after delivery (author's transl)].

Hemostasis and blood cell counts were studied during pregnancy, during labor, and after delivery in 76 women. Results were compared with data from a control group of 24 women. Previously published data are reviewed and the variations of studied factors are discussed. No reliable biologic test is available at present for assessing the risk of puerperal thromboembolism.

Adult

[Respective importance of the different risk factors for osteoporosis].

Among the factors which influence accumulation of bone mass, genetic factors related to race and family are preponderant: they account for approximately 80% of the variance observed in adulthood. At puberty, nutritional factors and physical activity modulate the accumulation of bone and determine whether or not optimal bone mass is achieved. In women, estrogen deprivation following menopause, and also more minor disorders of gonad function, are the main causes of decreased bone mass; their respective contributions are analyzed.

Adrenal Cortex Hormones