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Biomedical subjects

M A Parsons

Publications and source records attributed to M A Parsons.

At least 127 records · Page 7Linked to original sources
PubMed1983

Reservoir of St. Louis encephalitis virus in Ohio bats.

Inoculation of the big brown bat (Eptesicus fuscus) with a small dose of a St. Louis encephalitis (SLE) virus strain isolated in Ohio indicated that the big brown bat was susceptible to infection. The virus was maintained in the bats through hibernation (70 days), and the bats developed a viremia within 4 days of arousal from hibernation (105 days after inoculation). A field survey of 390 big brown bats and little brown bats (Myotis lucifugus) conducted in 5 regions of Ohio during 1979 to 1981 revealed a SLE virus-neutralizing antibody prevalence of 9%. Cohabitation of natural caves and abandoned mineshafts in Ohio by Culex pipiens mosquitoes, big brown bats, and little brown bats was also documented. Demonstration of a 9% prevalence rate of neutralizing antibody to SLE virus in big brown bats and little brown bats in Ohio during a nonepizootic period indicated that the bat may be involved in the maintenance of SLE virus in enzootic foci and could have a role in dissemination of SLE virus to epizootic foci.

Animals↗
PubMed1982

Xanthogranulomatous pyelonephritis: a reappraisal.

A survey was undertaken of the clinical, radiological, ultrasonic, and pathological features of 80 patients with xanthogranulomatous pyelonephritis (XPN). The condition is a progressive granulomatous reaction to chronic renal inflammation which is often suppurative and usually caused by calculous urinary tract obstruction. The characteristic pathological features are large numbers of foam cells containing lipid, and the presence of inflammatory destruction of neighbouring renal tissue. XPN, which is commoner than generally recognised, may often be diagnosed preoperatively--the patient is usually a middle-aged female who presents with severe toxaemia, tender loin mass, and mild lower urinary tract symptoms. The diagnosis is confirmed by radiology and ultrasonography. Nephrectomy is curative.

Adolescent↗
PubMed1982

Enolase isoenzyme distribution in the human brain and its tumours.

Using the immunoperoxidase PAP method we have studied the cellular distribution of alpha, beta and gamma enolase subtypes in normal human adult brain and in human brain neoplasms. Gamma enolase is found only in viable neurones throughout the brain. Alpha enolase is demonstrable in astrocytes, ependymal cells, capillary endothelial cells. Schwann cells and arachnoidal endothelial cells but oligodendrocytes appear to have low levels of this isoenzyme. Beta enolase is not demonstrable in normal brain tissues. Of the primary cerebral neoplasm studied only medulloblastomas and neuroblastomas did not contain demonstrable enolase. Astrocytomas, ependymomas, oligodendrocytomas, meningiomas and acoustic neuromas all contained varying quantities of alpha enolase. No cerebral tumours contained beta or gamma enolase. Tumour and adjacent brain tissue with histological evidence of ischaemia and necrosis showed loss of cellular enolase.

Adolescent↗
PubMed1982

Rectal malignant lymphoma in chronic ulcerative colitis.

Carcinoma of the colon as a complication of ulcerative colitis is relatively common, whereas malignant lymphoma is apparently rare; there are approximately 20 recorded cases. We report a case of follicular lymphoma of the rectum in a 73 year old woman with a 21 year history of ulcerative colitis. In view of the possible immune basis of ulcerative colitis, it is important to report and accurately classify cases of lymphoma arising in association with it.

Aged↗
PubMed1981

Lysozyme distribution in human lacrimal glands and other ocular adnexa.

In an immunohistochemical study of the human lacrimal glands and other orbital adnexa, lysozyme was found to be present in the major and accessory lacrimal glands but absent from meibomian glands and conjunctival epithelium. Almost all acinar and tubular cells in major and accessory lacrimal glands contain lysozyme, although occasional cells show diminished staining for lysozyme, probably because of secretion. Only one secretory lacrimal tubuloacinar cell type is demonstrable, although two types previously have been described. Lacrimal duct cells do not contain lysozyme. The findings of this study support the concept that the tubuloacinar cells of the main and accessory lacrimal glands are the sole source of the lysozyme secreted into tears.

Adult↗
PubMed1981

Distribution and prevalence of Mermet virus infections in the central United States.

Tests were run on 3,198 bird sera for neutralizing antibody of Mermet virus. The birds were mostly House Sparrows (Passer domesticus) captured in the central U.S. Antibody was detected in birds from Texas, Mississippi, Tennessee, Ohio, Indiana, Illinois, and Wisconsin, but not Kentucky or Missouri. Antibody prevalence differed by location and between years in similar locations. These results confirmed the widespread activity of Mermet virus in the central U.S., suggested irregular activity of the virus, and provided the first evidence that Mermet virus activity occurs in Mississippi, Indiana, and Wisconsin. No antibody to Mermet virus was found in paired sera from 966 humans with suspected arboviral infection.

Animals↗
PubMed1980

Treatment of infiltrating bladder carcinoma.

One hundred and seventy-five patients with invasive bladder tumours are reviewed. The overall crude survival rate was 30% at 3 years and 23% at 5 years. The 5-year survival rates for T2 and T3 tumours treated by radical radiotherapy were 38% and 28% respectively. Multiple urinary symptoms, obstruction, a large tumour, and poor differentiation were particularly unfavourable features.

Adult↗
PubMed1979

A light and electron microscope study on the origin of Foà-Kurloff cells.

Numerous Foà-Kurloff (FK) cells have been found in the circulation, spleen, bone marrow, thymus and placenta of guinea pigs under endogenous or exogenous oestrogenic stimulation. The origin of these cells is obscure. In the present experiment, the distribution of FK cells in organs other than those stated above was studied following gonadectomy and hexoestrol administration in guinea pigs of both sexes for either 1 or 10 weeks. More FK cells than those expected from the vascularity of the organ were found in the liver and lungs of male and female animals. The number of FK cells in these organs was larger after the long-term treatment with hexoestrol and it was accompanied by a significant decrease in the number of Kupffer cells of the liver. The latter observation is in contrast to previous reports of increased numbers of Kupffer cells in the liver of oestrogen-receiving mice, a species not producing FK cells. These observations suggest a relation between the two types of cells. No transformation of mature Kupffer cells into FK cells was seen with the electron microscope. However, other findings suggest that both Kupffer cells and FK cells may well be derived from a common precursor of MPS in the bone marrow.

Animals↗