INHIBITION OF HUMAN TUMOR CELLS BY CORDYCEPIN.
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Biomedical subjects
Publications and source records attributed to M A RICH.
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Inoculation of cell cultures of fetal skin of human and murine origin with virus extracted from human wart tissue resulted in the appearance of intracellular wart virus specific antigen, as demonstrated by fluorescent antibody techniques. Appearance of antigen was accompanied by cytopathogenicity and the accumulation of large numbers of characteristic virus particles.
If the association between chromosome aberrations and leukemia is a causal one, the aberrations should be present before the appearance of tumor. In a virus-induced murine leukemia in which the pre- and early leukemic stages were defined, aneuploidy was observed only during the later stages of the disease. This suggests that the chromosome alteration results from, rather than initiates, the neoplastic transformation.
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