Introduction of the 5-ioduracil moiety into deoxyribonucleic acid of mammalian cells.
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DNA↗
Biomedical subjects
M A RICH
Publications and source records attributed to M A RICH.
Growth inhibition of chick-embryo cells by some 5-fluorinated pyrimidines: effect on Rous sarcoma virus infection.
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Animals↗
Introduction of the 5-halogenated uracil moiety into deoxyribonucleic acid of mammalian cells in culture.
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DNA↗
Incorporation of unnatural pyrimidine bases into deoxyribonucleic acid of mammalian cells.
When a mammalian cell strain was incubated with 5-iododeoxyuridine and 5-bromodeoxyuridine, DNA thymine was partially replaced by the halogen-containing pyrimidines. The extent of incorporation of the unnatural bases increased when amethopterin and hypoxanthine were added to the medium. It is thus evident that the replacement of DNA thymine by selected structural analogs, a phenomenon previously reported for bacterial systems, is applicable to cells of higher organisms.
Alkalies↗
Growth inhibition of a human tumor cell strain by 5-fluoro-2-deoxyuridine: time parameters for subsequent reversal by thymidine.
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Animals↗
Growth inhibition of a human tumor cell strain by 5-fluorocytidine and 5-fluoro-2'-deoxycytidine: reversal studies.
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Animals↗
Studies on Cryptococcus nigricans. II. The effects of physical, chemical and nutritional factors.
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Cryptococcus↗
Studies of Cryptococcus nigricans n. sp. I. Identification and taxonomic classification.
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Cryptococcus↗
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
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Antineoplastic Agents↗
The pathogenicity of Dematium nigrum for mice.
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Animals↗
The reversal of quaternary ammonium detergent inhibition of Saccharomyces cerevisiae by a fraction derived from yeast extract.
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Ammonium Compounds↗