PubMed Health⌕ Search

Biomedical subjects

M A Samsonov

Publications and source records attributed to M A Samsonov.

122 records · Page 7Linked to original sources
PubMedDate not supplied

[Effect of diet therapy on the immunological indices in rheumatism].

Rheumatic patients with torpid and latent course of the process were kept on a protein-rich diet (up to 140.0 g of protein). The effect of the diet on the organism was appraised by the peripheral blood lymphocytes blast-transformation reaction, as the one most comprehensively reflecting the immunological status of the individual. The patients were examined in dynamics, on admission to and at the time of discharge from the clinic. The data thus obtained suggest that the protein-rich diet tends to bring down the number of activated cells in in vitro cultures.

Antigen-Antibody Reactions↗
PubMedDate not supplied

[Parameters of polynuclear cell activity in torpid and latent recurrent rheumocarditis in the process of treatment with a high-protein diet and drug preparations].

The in vitro test of direct granulation of basophils affected by specific antigens (cardial tissue, acid-soluble fraction of collagen, streptococcal allergens) was investigated in the course of treating 41 patients (29 women and 12 men aged from 20 to 50 years) suffering from a little active rheumatic fever. The patients received a complex of therapeutic measures including high-protein diet (130-140 g protein) and drugs (1.5-2.0 g acetylsalicylic acid and 15 mg of prednisolone a day). As a result of the treatment all the patients improved and demonstrated pain relief in the heart region, reduced palpitation, abatement of general weakness and fatigue. At the same time there was a decrease in the reactivity of basophilic leukocytes, shown by less number of degranulated cells in vitro, activated with specific antigens.

Adult↗
PubMedDate not supplied

[Effect of a reducing diet on metabolic disorders in ischemic heart disease patients having excess weight].

The paper concerns the effect of the diet with a strongly reduced content of carbohydrates, with a restriction of table salt and extractive substances on lipid and carbohydrate metabolism, on catecholamine secretion and exocrine pancreatic function in patients with ischemic heart disease accompanied by overweight and disturbed carbohydrate tolerance. Dietetics has a normalizing action on the body overweight, lipid composition and lipoproteid spectrum, as well as on the enhanced activity of serum trypsin. Moreover, it makes the blood content of immunoreactive insulin return partially to normal.

Adult↗
PubMedDate not supplied

[Comparative evaluation of the role of protein in the diet therapy of ischemic heart disease and rheumatism with a slight degree of activity].

The patients with chronic heart disease (265 subjects) and with little active rheumatic fever (145 subjects) received two variants of isocaloric diets which differed only in protein quota. The former diet contained the physiological norm of protein (100 g) and the latter one a higher quota (130 g). As a result of the treatment the subjective sensations and objective status of all the patients improved. Evaluation of the time course of lipid metabolism, the system of hemostasis, capillary permeability and immunological reactivity showed that the diet containing the physiological norm of protein appeared the most effective in patients with ischemic heart disease, whereas that with a higher protein quota turned out the most adequate in patients with rheumatic fever.

Adult↗
PubMedDate not supplied

[Cholesterol metabolism in patients with ischemic heart disease with varying supplies of omega-3 polyunsaturated fatty acids].

Patients with ischemic heart disease and with hyperlipidemia of the IIa, IIb and IV types as well as not exhibiting any pronounced alterations in cholesterol metabolism were treated with various amounts of omega-3 polyunsaturated fatty acids (PUFA) introduced into the basic antiatherosclerotic diet: 1 group--content of the essential factor 0.2 g/day, 2 group--increased content of natural products with PUFA up to 1 g/day, 3 group--increased PUFA content due to the drug "euconol" 5 g/day. Administration of the PUFA omega-3 into the basic antiatherosclerotic diet contributed to development of adequate clinico-biochemical alterations; under these conditions content of alpha-cholesterol in blood correlated directly to concentration of polyunsaturated cholesterol esters and PUFA omega-3 (eicosapentaenate and docosahexaenate) as well as reverse correlation was found between content of total cholesterol and these molecular forms of cholesterol esters studied. Enrichment of the diet with PUFA omega-3 did not cause any alterations in content of primary bile acids in blood thus suggesting that PUFA omega-3 did not affect the cholesterol catabolism. These data enabled us to plot the graph for individual evaluation of cholesterol metabolism in patients with ischemic heart disease involving alterations in the spectrum of esterified cholesterols in blood before and after the treatment course.

Cholesterol↗
PubMedDate not supplied

[Effect of anti-arteriosclerosis diet, containing soya protein isolate and omega-3 polyunsaturated fatty acids on the activity of mononuclear and platelet lysosomal hydrolases in patients with hypertension and ischemic heart disease].

In response to antiatherosclerosis dietotherapy containing 20 g of ichthyenic oil, coronary and hypertensive subjects showed lowered serum levels of cholesterol, triglycerides and atherogenic index, elevated HDLP cholesterol and corrected immunochemical shifts. SPI-containing diet resulted in changes of CIC IgM levels only. Shifts in the activity of mononuclear and platelet lysosomal hydrolases which occurred in the above patients due to relevant diets reflect higher sensitivity of this parameter in assessment of the dietotherapy effectiveness.

Adult↗
PubMedDate not supplied

[Effects of polyunsaturated fatty acids of the omega-3 family in the anti-atherosclerotic diet on the activity of lysosomal lipolytic enzymes, mononuclear cells and blood platelets of patients with ischemic heart disease].

Prior to diet therapy, CHD patients exhibited marked impairment of the system of platelet and mononuclear lysosomal lipolytic enzymes compared to those in healthy controls. A reduced ratio of polyunsaturated fatty acids omega-6/omega-3 in low-sodium hypolipidemic diet (from 10.3 to 6.3-1.3) incorporating halibut flesh and ichthyoic oil promoted its antiatherogenic efficacy. The activity of platelet and mononuclear lysosomal lipolytic enzymes and lipid spectrum in coronary patients returned to normal values.

Adult↗
PubMedDate not supplied

[Clinico-metabolic effects of fish oil in patients with ischemic heart disease, familial hyperlipoproteinemia and hypertension].

Fifty-five patients with ischemic heart disease, familial hyperlipoproteinemia type IIb and essential hypertension kept anti-atherosclerosis diet incorporating 20 g of ichthyenic oil for 4 weeks. The diet resulted in positive shifts in clinical manifestations, a fall in blood levels of total cholesterol, triglycerides, atherogenic coefficient. The clotting time and duration of hemorrhage proved longer. As to fatty acid composition of red cell and platelet membranes, proportion of omega-6 reduced, while the share of omega-3 rose. This may underly inhibited synthesis of PGE2 and PGF2 alpha noted in the examinees.

Adult↗
PubMedDate not supplied

[Characteristics of the humoral immune system and lipid peroxidation processes in people living in territories contaminated with radionuclides].

Among 33 patients with Stage II hypertension, 25 persons were inhabitants of the Russian radionuclide-contaminated areas and 8 patients had no prior contacts with ionizing radiation (control). All the patients examined were maintained within 4 weeks on a diet, radioprotective effect of which was realized due to the elevated content of sulfur containing amino acids, antioxidants and complexes. In the patients who lived in the radionuclide-contaminated areas, a moderate activation of lipid peroxidation was detected simultaneously with marked alterations in the humoral component of the immunity system, which involved a considerable increase in the levels of IgG and complements C3 and C4. A decrease in content of malonic dialdehyde and diene conjugates as well as normalization of IgG and decrease in content of IgA, IgM and C3 were observed in blood plasma of the patients on diet. Supplementation of omega 3 polyunsaturated fatty acids (omega 3-PUFA), 5 g/day and alpha-tocopherol, 12.5 mg/day, to the diet elevated the serum concentrations of all lg classes, which suggests the presence of an immunomodulating effect of omega 3-PUFA. Moreover, the content of malonic dialdehyde was not increased in blood plasma if 3-PUFA was used. Hence, increased alpha-tocopherol levels should be used in the treatment of these patients with omega 3-PUFA (up to 5-7 mg per g PUFA) in order to stabilize lipid peroxidation.

Accidents↗
PubMedDate not supplied

[Effect of an anti-atherosclerotic diet with different protein content on catecholamine and DOPA excretion in patients with ischemic heart disease and excess weight].

In patients with ischemic heart disease (IHD) with excess body weight the excretion of catecholamines and DOPA was investigated. In patients of middle and advanced age the excretion of norepinephrine was found to be down, while in those of the young age the excretion of epinephrine and norepinephrine proved to be up. There exist a correlation between the rising level of norepinephrine and hyperlipidemia. In patients with IHD the blood serotonin content is elevated. The use of an antiatherosclerotic diet with a higher protein content tends to bring down the level of the norepinephrine and, partially, also of epinephrine excretion. With patients kept on an antiatherosclerotic diet with protein content the excretion of norepinephrine sharply decreases and that of epinephrine rises. Administration of pyridoxine superimposed upon dietary variants acts favorably on the catecholamines excretion. Under the effect of the diets in question the blood serotonin remains unchanged. The implication is that both the high- and low-protein quotas in the composition of antiatherosclerotic diets do not produce an optimal effect on the catecholamines and DOPA metabolism in patients with IHD and an excess body weight.

Adult↗
PubMedDate not supplied

[Assessment of the protein quota in the ration of patients with the nephrotic syndrome according to balance studies].

From data derived from equilibrium investigations in patients with the nephrotic syndrome a negative nitrous balance which indicates the presence of a chronic protein deficiency developing in the organism of these patients was revealed. Observations showed that an increased quota of protein in the ration of patients with the nephrotic syndrome is quite justifiable. The quantity of protein comprising 1.5--2 g per kg of the patient's body weight per day, of which 3/4 is protein of animal origin, is optimal for this category of patients. Possible improvement of the protein supply in patients with the nephrotic syndrome is largely determined also by the qualitative composition of the protein in the ration.

Dietary Proteins↗