Biomedical subjects

M Albin

Publications and source records attributed to M Albin.

62 records · Page 4Linked to original sources

PubMed1978

Heterospecific activity of rat interferon.

In the experiments performed in vitro and in vivo it has been found that the rat and rat embryo fibroblasts cultured in vitro after the induction with virus produce interferon which displays the antiviral activity not only in the homologous cells but also in the heterologous ones. When analysed by chromatography on Sephadex G-100 it was shown that the rat serum contains two interferon populations differing in the molecular weight and both active in the homologous and heterologous cells. The interferon with the heterospecific activity has been used in the experimental therapy of mice infected with Encephalomyocarditis Virus (EMC), Vesicular Stomatitis Virus (VSV) and Influenza Virus, and was found to be effective.

Animals↗

PubMed1977

The influence of immunization on the production of interferon in vivo and in vitro.

The present study was undertaken to compare the production of interferon by immunized mice in response to different viral inducers. Porton mice were immunized with NDV or A/Wr11/57 virus by injecting 6-week-old animals with virus on days 1, 7, and 14. The interferon response was investigated 3 weeks later. Compared with controls, the A-immunized mice after stimulation in vivo, produced more interferon when NDV was used as inducer. It was shown in sera as well as in washings of peritoneal cells. In experiments in vitro induction of interferon with NDV or A/Wr11/57 virus in macrophages of immunized mice resulted in significant rise in interferon levels. These results are in agreement with earlier investigation of others and support the role of immune recognition in the interferon response.

Animals↗

PubMed1973