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M Alper

Publications and source records attributed to M Alper.

At least 37 records · Page 2Linked to original sources
PubMed2000

Heterotopic bone formation in two cases of colon carcinoma.

Heterotopic bone formation is rare in the gastrointestinal tract. We here present the clinical and pathologic details of a 56-year-old male patient with mucinous adenocarcinoma of the colon and a 70-year-old male patient with colon metastasis previously operated on for signet-ring-cell carcinoma of the stomach who was treated with radiotherapy postoperatively. Both of them showed diffuse bone metaplasia. Heterotopic bone formation is usually present with mucin-producing benign or malignant tumors. The pathogenesis of osseous metaplasia is not well known; however, it is speculated that the extravasation of mucin may have a stimulatory role.

Adenocarcinoma, Mucinous↗
PubMed2000

Transsacral usage of a pure island TRAM flap for a large sacral defect: a case report.

A pedicled transverse rectus abdominis musculocutaneous (TRAM) flap was used to reconstruct a large sacral defect retroperitoneally. Muscle and superiorly located skin were elevated on the deep inferior epigastric pedicle. The flap was transposed retroperitoneally from the abdominal wall to the sacral region of the patient. The selection criteria for this particular flap are discussed and compared with other reconstructive choices.

Abdomen↗
PubMed2000

The role of periosteum and different dissection types on callus formation: quantitative analyses with scintigraphy in a rabbit mandible model.

In this experimental study, the effects of different dissection types and the role of the periosteum on callus formation were investigated. Forty-five rabbits were divided into three groups of 15 rabbits. In the first group, a classic subperiosteal dissection was performed to reach the mandible. In the second group, the dissection was done extraperiosteally between the periosteum and the muscle. In the third group, the periosteum at the osteotomy line was stripped out bilaterally both on the lingual and the buccal sides (1.5 cm wide on each side). In all groups, linear vertical osteotomy was performed using an oscillating saw, and fracture fragments were fixed with surgical wire. The animals were evaluated using biomechanical (traction test), histological, and scintigraphic methods. The most durable callus in the traction test and, scintigraphically, the most rapid remodeling were seen in the second group. The histological study performed during week 3 revealed immature callus formation in the first and second groups, and no such formation in the third group. At week 8 the callus was mature in the first two groups and in the third group it was seen but not mature.

Animals↗
PubMed2000

The role of oxygen free radicals and nitric oxide in organ injury following hemorrhagic shock and reinfusion.

BACKGROUND: Vital organ injury due to tissue hypoperfusion is a major complication of hemorrhagic shock. Nitric oxide (NO) has been implicated in the pathophysiology of hemorrhagic shock. AIMS: To determine the effects of L-arginine on the central organ injury due to severe hemorrhagic shock and reinfusion and the relationship among endogenous antioxidants, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in dogs. METHODS: After induction of anesthesia, twenty six mongrel dogs were hemorrhaged to a mean arterial pressure (MAP) of 35 +/- 3.3 mmHg where they were held for 1 hr. Five minutes prior to the end of the shock period, either saline (5 mL/kg), L-arginine (250 mg/kg), or NG-nitro-L-arginine-methyl-ester (L-NAME) (25 mg/kg) was administered i.v., being followed by reinfusion of shed blood. MAP was monitored. Blood samples were taken for the measurement of blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), intraerythrocytic SOD, CAT, GSH-Px, and serum nitrite and nitrate levels. Tissue samples from liver, kidney and small intestines were taken for histological studies and liver samples were also taken for the mesurement of SOD, CAT, GSH-Px tissue levels. RESULTS: L-arginine treatment reduced MAP. In contrast, L-NAME treatment significantly increased MAP. L-arginine treatment increased BUN and creatinine. L-NAME treatment significantly increased the activity of hepatic enzymes. L-arginine decreased the reinfusion injury in the liver and the small intestine histopathologically. In addition, L-arginine caused significant decreases in the intraerythrocytic and the liver SOD, CAT and GSH-Px levels from the shock levels. CONCLUSION: L-arginine has a preventive role in liver and intestine following hemorrhagic shock and reinfusion. Inhibition of NO synthesis aggravates reinfusion injury.

Animals↗
PubMed1999

Isolated cremaster flap: A modified model in intravital microscopy.

Inspection of the microcirculation in living tissues has been accomplished using various models. The rat cremaster muscle has been used for this purpose for more than 20 years. In our study, for the first time, the pedicle of the cremaster muscle has been catheterised indirectly in order to perfuse and drain the muscle and to obtain blood samples. The assessment of the effects of a variety of perfusants on the microcirculation after reperfusion injury can be carried out by using this model.

Animals↗
PubMed1999

Aplasia cutis congenita with epidermolysis bullosa: a case report.

A child with epidermolysis bullosa and aplasia cutis congenita is presented. This is a very rare condition that represents an unusual manifestation of epidermolysis bullosa. Management of aplasia cutis congenita is controversial and may be conservative, surgical, or a combination of the two. In this patient, surgical treatment with split-thickness skin grafts failed, and conservative treatment using silver-sulfadiazine cream dressings was instituted.

Anti-Infective Agents, Local↗
PubMed1999

Modified McIndoe procedure for vaginal agenesis.

Between 1982 and 1997, 29 patients with congenital absence of the vagina underwent modified McIndoe vaginoplasty at the Division of Plastic and Reconstructive Surgery, Ege University Medical School, Izmir, Turkey. As a modification, an X incision was utilized instead of a straight-line horizontal or sagittal incision. During the first postoperative week, a perforated Pyrex rigid mold was used. This was replaced with an unperforated mold at the end of the first week. These patients' medical records were reviewed retrospectively. Complications encountered included infection, total lack of skin graft take, stress urinary incontinence, partial graft loss, and vaginal stricture. All complications were treated except the stress urinary incontinence, and the final results were satisfactory.

Adolescent↗
PubMed1999

Anatomic variations of the infraorbital foramen.

The aims of this study were to locate the infraorbital foramen and to determine the frequency and location of any accessory foramen, which may be troublesome during anesthetization of this region. In 45 cadavers, the infraorbital foramen was dissected according to classic principles for location. The line between the angulus oculi medialis and the angulus oculi lateralis was divided into three equal pieces, and a second line was drawn downward, perpendicular to the point uniting the internal and medial thirds. The position of the infraorbital foramen was determined in relation to that line and the infraorbital margin. For the right and left sides, the infraorbital foramen was found to be on that line in 75.6% and 68.9% of the specimens, respectively. The infraorbital foramen was 10.9 mm and 8.3 mm under the infraorbital margin in men and women, respectively. Regarding accessory foramen, 119 crania and 229 maxilla were observed (a total of 467 infraorbital foramen), and it was found that single accessory foramen were present in 11.5% of specimens and double accessory foramen were present in 1.28% of specimens. In 79.6% of specimens with single accessory foramen, the accessory foramen was superior and medial to the main opening. These results are helpful in decreasing anesthetic complications.

Anesthesia↗
PubMed1999

Congenital infiltrating lipomatosis of the face.

Congenital infiltrating lipomatosis of the face is a rare clinical entity. Since it was first described by Slavin and colleagues in 1989, only a few cases have been reported in the literature. A 6-year-old girl with congenital infiltrating lipomatosis of the right side of the face is presented, and treatment modalities are discussed.

Child↗
PubMed1998

Gunshot wounds of the face in attempted suicide patients.

PURPOSE: The purpose of this retrospective study was to evaluate the functional and cosmetic results of the treatment of gunshot wounds associated with attempted suicide that resulted in facial injury. PATIENTS AND METHODS: The records of 12 patients with facial injury resulting from gunshot wounds with a suicidal origin, who were hospitalized and treated at Ege University Hospital, Department of Plastic and Reconstructive Surgery, were reviewed. RESULTS: All injuries were limited to the head and neck region; in only one patient did intracranial penetration occur. Mandibular fractures were detected in all cases. Fractures of the maxilla were present in 11 patients. Eight patients suffered from zygomatic fractures. Perforating ocular trauma was present in two cases. Soft tissue repair was performed by primary closure, local flaps, or skin grafts, and rigid fixation was used for fractures. Procedures such as distant flaps or bone grafting were left for delayed reconstruction. CONCLUSION: Only 3 of 12 patients returned for follow-up and reconstruction. It was therefore concluded that relatives of these patients believe that the repair of such deformities, even if it is a functional deformity, is not necessary. Thus, in such cases, one should do as much reconstruction as possible at the primary surgical intervention.

Adolescent↗
PubMed1998

McCune-Albright syndrome progressing with severe fibrous dysplasia.

We present the case of an 11-year-old girl with McCune-Albright syndrome associated with severe fibrous dysplasia. In addition to bone lesions, she has apparent manifestations of precocious puberty. In examination, a mass at the mentum spreading to mandibular corpus bilaterally was seen. This mass has affected the mandibular teeth. It was nearly 20 x 20 x 15 cm in size and had local necrotic regions on it. The lower lip was expanded too much by the mass. Another mass filled the left maxillary sinus, expanding the left zygomatic region outwardly and closing the left nasal fossa completely. A rectangular skull shape was related to the involvement of cranial bones. After stainless steel, custom-made mandibular prosthesis was prepared, the patient underwent surgery. A partial mandibulectomy was performed, and resulting mandibular bone defect was reconstructed by steel prosthesis. Craniofacial involvement occurs in 100% of disseminated cases. In the dental literature, mandibular involvement was found in 20% of cases. However, in studied literature, we did not find a dramatic mandibular lesion as severe as that presented here.

Acute Disease↗
PubMed1998

Intraorbital osteoma and surgical strategy.

The most common tumoral lesion of the bony orbital region is osteoma. It is an infrequent and benign tumor, and generally attacks the craniofacial skeleton, but intraorbital involvement is extremely rare. After necessary radiologic examinations (radiographs and computed tomography scanning), surgery should be planned according to the tumor's localization. In the case presented here, osteoma originated mainly from the medial orbital wall. Therefore, for better surgical exposure, extra- and intracranial approaches were planned and carried out. The mass was removed successfully. At the 3-year follow-up, no recurrence was shown.

Adult↗
PubMed1998

Total lymphocyte and T lymphocyte subpopulation levels in head and neck squamous cell carcinomas.

This study was performed on 72 patients with head and neck squamous cell carcinoma. Total lymphocyte, natural killer cell and total lymphocyte subpopulation levels in peripheral blood were determined and the correlation of these levels with TNM and Histopathologic Malignancy Grading (HMG) systems were investigated. TNM and HMG systems, which are two important prognostic indicators, were significantly correlated whereas total lymphocyte, natural killer cell and total lymphocyte subpopulation levels in peripheral blood had no correlation with TNM and HMG scores.

Carcinoma, Squamous Cell↗