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Biomedical subjects

M Andersen

Publications and source records attributed to M Andersen.

At least 37 records · Page 2Linked to original sources
PubMed1990

[The occurrence of late thromboembolic complications after elective abdominal surgery].

Forty-five consecutive patients who were submitted to elective major abdominal surgical interventions under optimal thromboembolic prophylaxis participated in an investigation as regards the occurrence of late thromboembolic complications. The patients were followed postoperatively with 125I-fibrinogen scanning every second day for a week or until discharge from hospital. If deep venous thrombosis was suspected, intravenous phlebography was carried out. Thirty-five patients completed the investigation. None of the patients developed deep venous thrombosis during thromboembolic prophylactic treatment. In two patients (6%) (95% confidence limits 1-19%), deep venous thrombosis was demonstrated after conclusion of prophylaxis, 13 and 28 days postoperatively, respectively. It is concluded that despite optimal thrombosis prophylaxis, late thromboembolic complications may occur. Prospective investigations are required to elucidate the clinical significance of late thromboembolic complications and to illustrate the value of prolonged thrombosis prophylaxis.

Adult↗
PubMed1990

The developmental morphology of a "periosteal" ligament insertion: growth and maturation of the tibial insertion of the rabbit medial collateral ligament.

The structural properties of ligament insertions change dramatically during growth and maturation, but little is known about their developmental anatomy. This study describes and quantifies changes in the gross and microscopic anatomy of the tibial insertion of the rabbit medial collateral ligament (MCL) during development and at skeletal maturity. Eighty animals were used for growth and descriptive studies. From this group, 27 animals, ranging in age from 1 to 24 months, were injected with fluorescent bone markers and their tibial insertions were processed undecalcified for histology. Sections were examined by polarized light and fluorescence microscopy to identify matrix and cells and to quantify mineral formation. Results showed that animals achieved histological skeletal maturity between 9 and 12 months of age. Body weights were a poor index of skeletal maturity. The tibial insertion was composed of five tissue layers, which changed proportions during growth and maturation. In immature animals, MCL fibers entered the periosteum; in older animals, MCL fibers were cemented to the tibia by advancing mineral. The tibial attachment of the MCL was thus transferred from the periosteum to the cortex during growth, suggesting that the term "periosteal insertion" is imprecise in adults. The hypothesis is put forward that these structural changes account for the reported increase in tensile failure of this insertion near skeletal maturity.

Aging↗
PubMed1990

Second-line chemotherapy in small cell lung cancer.

The literature on second-line chemotherapy in small cell lung cancer (SCLC) for the period 1979-1989 is reviewed. The reports consisted mainly of Phase II type studies and comprised a total of 987 patients with relatively few patients per study. The information was frequently incomplete with regard to duration of response on first-line chemotherapy, length of any drug-free interval and duration of response on second-line chemotherapy. The overall second-line response rate was 30%, but only 5% were complete responses (CR). The response rates obtained by the combination of cisplatinum (P) and VP-16 (E) or reinduction therapy were 45% and 64% (medians), respectively. These rates were superior to regimens consisting of supposedly non-cross-resistant agents. With P and E not given in combination, the response rates were less than 20%.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

Effect of major surgery on absorption rate of NPH insulin injected s.c.

The absorption rate of NPH insulin injected s.c. was evaluated before operation and on the day of surgery by continuous measurements of residual radioactivity of 125I-labelled insulin in 10 patients undergoing major abdominal surgery. The results show that major surgery has no effect on rate of absorption of intermediate acting insulin.

Abdomen↗
PubMed1989

[Electrocoagulation as radical treatment of anorectal cancer].

During a 17 year period, 19 patients with ano-rectal cancers were treated radically by electrocoagulation. Ten patients (52%) were treated successfully with electrocoagulation as the only treatment. The method is recommended as an alternative to radical surgery in carefully selected patients. The patients should be followed up at regular intervals. No serious complications occurred.

Aged↗
PubMed1989

The arterial supply of the clavicle.

This report based on delineation of the arterial system with 3 component plastic material on 10 human cadavers describes the arterial supply to the clavicle. The study was performed in 2 parts. One part, which showed the total arterial supply to the clavicle and one part with selective injections of the relevant arteries, with the intention of finding a central nutrient arterial supply to the clavicle. Three arteries were found to supply the clavicle: the suprascapular a.; the thoracoacromial a.; and the internal thoracic (mammary) a. The main supply was primarily periosteal. No nutrient artery was found.

Aged↗
PubMed1989

The effect of general anaesthesia on the haemodynamic events during laparoscopy with CO2-insufflation.

Sixteen women were studied during elective diagnostic laparoscopy with CO2-insufflation to an intraabdominal pressure (IAP) of 2 kPa and Trendelenburg tilt to 30 degrees. They were allocated to either a halothane (Group I) or a balanced (Group II) anaesthesia with relaxation and controlled ventilation. Heart rate (HR), arterial pressure, stroke volume, CO2-elimination, end-tidal CO2 vol.% and total respiratory compliance (TRC) were the parameters measured, and mean arterial pressure (MAP), total peripheral resistance (TPR), stroke index (SI) and cardiac index (CI) were calculated. At maximum haemodynamic strain, SI and CI were on average reduced by 42% in both groups, without significant changes in HR and MAP. TPR increased by 50% in Group I and 100% in Group II. The reduction in SI was related to the changes in TRC. A small increment in CO2-elimination after CO2-insufflation was most pronounced in Group II. SI and CI did not reach the pre-insufflation values after return to the horizontal position and CO2-exsufflation. The haemodynamic differences between the two groups were small compared to the effects of the laparoscopy procedures.

Adolescent↗
PubMed1987

Antiglobulin serum mediated phagocytosis of normal senescent and oxidized RBC: role of anti-IgM immunoglobulins in phagocytic recognition.

Fresh human monocytes usually do not recognize normal RBCs; however, in our newly developed assay antiglobulin-opsonized normal RBCs were phagocytized. Both anti-IgG and anti-IgM fractions present in the antiglobulin serum were involved but the major opsonin was anti-IgM. The anti-IgM opsonized mainly senescent RBCs and therefore could be used to discriminate young from senescent RBCs. The antiglobulin serum and monospecific anti-IgM increased opsonization of in vitro oxidized and desialylated RBCs, whereas trypsin-treatment of RBCs decreased phagocytosis. The material removed by trypsin from the RBCs surface inhibited the antiglobulin and monospecific anti-IgM phagocytic assay supporting the view that membrane associated elements crossreacted with anti-IgM. These results suggest that both internal cellular events and external removal of sialic acid play a role in the emergence of non-IgG covered epitopes on the surface of senescent and oxidized erythrocytes.

Antibodies, Anti-Idiotypic↗
PubMed1986

Transcervical thymectomy in patients with nonthymomatous myasthenia gravis.

Transcervical thymectomy was performed during a 13-year period in 21 patients with nonthymomatous myasthenia gravis. Follow-up showed that only eight patients benefited from the operation. These eight were among the younger patients in the series. This observation is discussed, and also the theoretic background for early thymectomy. The transsternal approach is recommended for thymectomy in elderly patients, but the transcervical may be considered for younger patients, although transsternal reexploration is advocated if this first operation should fail.

Adolescent↗