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Biomedical subjects

M Angel

Publications and source records attributed to M Angel.

29 records · Page 2Linked to original sources
PubMed1982

Murine colonic mucosal metabolism and cytotoxicity of benzo [alpha] pyrene.

Homogenates of colonic mucosa from seven mouse strains metabolized 14 C-benzol [alpha] pyrene (BP) to alkali-soluble and water-phase products. In those strains in which liver aryl hydrocarbon hydroxylase activity is inducible by beta-naphthoflavone (beta-NF), the C57Bl/6, BALB/c, C3H and random-bred Swiss CD-1, colonic metabolism of BP was also induced by intraperitoneal treatment with 150 mg/kg beta-NF 24 h before assay. No increase in the colonic metabolism of BP was seen after beta-NF treatment of the noninducible strains, AKR, DBA and SWR. A detailed study of the products formed was carried out with C57BL/6 male mice. High-performance liquid-chromatography analysis of the products of BP metabolism revealed that phenolic derivatives predominated, but that a small percentage of the BP was converted into the proximate carcinogen, the BP-7,8-diol. Addition of uridine 5'-diphosphoglucuronic acid to the incubation mixture caused an increase in total product formation and a shift from alkali-soluble to water-phase products. Of the water-phase products formed by beta-NF-induced colonic mucosal homogenates, about 40% were nondialyzable and associated with precipitable material. In a study of the cellular effects of BP on the colonic mucosa, intrarectal administration of 1 mg BP had a significant cytotoxic effect, as indicated by the number of pyknotic cells and 3H-thymidine-labeling index, and prior treatment with beta-NF afforded significant protection against this cytotoxicity.

Animals↗
PubMed1979

[Sarcoidosis, toxic thyroid adenoma, and De Quervain's thyroiditis. Association or coincidence (author's transl)].

The case of an association of three well-differentiated pathologies is reported. A 40-year-old woman with a toxic thyroid adenoma developed acute polyarthritis during the course of the disease. The articular symptoms together with chest X-rays and a consistently negative PPD (1:100) were suggestive of sarcoidosis. This was later confirmed by the discovery of non-caseating granulomas in the liver and superficial lymph nodes, and by a positive Kveim's test. Histopathologic examination of the thyroid gland confirmed the existence of the adenoma. Sarcoid infiltration was not observed, but on the other hand the typical images of subacute granulomatous thyroiditis (De Quervain's thyroiditis) were discovered.

Acute Disease↗
PubMedDate not supplied

Tissue-expanded radial forearm free flap in neck burn contracture.

Neck contracture after burn injury can result in severe functional as well as aesthetic deformities. Contracture can recur even after wide and complete release and full-thickness skin grafting. Recurrence is partly due to the inherent difficulties in both early postoperative immobilization and the required long-term splinting. When adjacent tissues are also burned, adequate local tissue for reconstruction may not be available; therefore, free-tissue transfer may be necessary. The large surface area that is required after adequate release may be provided by tissue expansion before free-tissue transfer. In the case presented the use of tissue-expanded radial forearm free flap for the reconstruction of a recurrent neck contracture is described.

Adult↗