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Biomedical subjects

M Anke

Publications and source records attributed to M Anke.

At least 37 records · Page 2Linked to original sources
PubMed1984

Nickel--an essential element.

Nickel is necessary for the biosynthesis of the hydrogenase, carbon monoxide dehydrogenase, and of factor F 430, found in a number of genera of bacteria. Urease from jack beans and several species of plants is also a nickel protein. These plant enzyme systems can affect animals via the microbiological digestion of food in the rumen. Nickel is a constituent part of all organs of vertebrates. Its absorption can be controlled. Low nickel offers reduce growth; this is particularly true of intra-uterine development. Such offers also decrease the life expectancy of reproducing animals. Nickel deficiency is accompanied by histological and biochemical changes and reduced iron resorption and leads to anaemia. It can disturb the incorporation of calcium into skeleton and lead to parakeratosis-like damage, which finds expression in disturbed zinc metabolism. Nickel deficiency results in lower activities of different dehydrogenases and transaminases and, above all, of alpha-amylase, and particularly affects carbohydrate metabolism. A marked decrease in metabolism was observed in the case of the energy sources fat, glucose, and glycogen. Nickel therefore performs a vital function in metabolism: it is an essential element. The nickel requirements of human beings and animals amount to less than 500 micrograms/kg and are probably even considerably lower. It therefore follows that, in view of the available nickel offer, primary nickel deficiency in human beings and animals can be excluded, at least in the present state of knowledge. On the other hand, it should be remembered that, 25 years after the discovery of the essentiality of manganese, this element was included among the trace elements of academic importance only, whereas today it is a feed additive.

Aldehyde Oxidoreductases↗
PubMed1983

Long term toxicological studies on the progestin STS 557.

The toxicity of 17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one (STS 557) was studied by its oral administration of 0.1, 1.0 or 10.0 mg/kg/day to Wistar rats for six months, and of 0.01, 0.1 or 1.0 mg/kg/day to beagle dogs for six months, respectively. Levonorgestrel at a dose of 1.0 mg/kg/day was used as the standard in the dog study. With respect to the progestational activity of the compound the main target organs were the hypophysis, the reproductive organs and the adrenals. Mammary hyperplasia was observed in dogs treated with STS 557 or levonorgestrel at the dose of 1.0 mg/kg/day, but in no case mammary nodules could be detected. At the dose of 1.0 mg/kg/day STS 557 and levonorgestrel were found to increase the plasma insulin response to i.v. glucose in bitches, but neither the mean blood glucose levels nor the glucose utilization were affected. Moreover, during administration of both steroids to dogs temporary changes in serum concentrations of triglycerides and total cholesterol were noted. The results obtained in rats and dogs from functional and morphological investigations did not reveal any toxic side effects of STS 557 on the liver, the kidneys, the bone marrow or on blood coagulation. The effects on the reproductive organs observed following STS 557 especially in dogs are related to both the hormonal effects of the compound and the specific response of the dog to potent progestagens.

Animals↗
PubMed1982

[Composition and food value of the flat pea (Lathyrus sylvestris L.)].

Flat pea (Lathyrus sylvestris L.) is suitable as 'pioneer plant' for the recultivation of slag heaps and mining areas for agricultural production. Flat pea contains between 20 and 30% crude protein in the dry matter and is richer in protein than other feed legumes. It is comparable to foxtail clover and lucerne as regards the content of amino acids (g/16 g N) and minerals. The digestibility of the crude nutrients of various dried products of flat pea was ascertained in seven experiments with five rams. The digestibility of the organic matter of the hay (before budding) was 66.2%, energy concentration 526 EFU/kg DM; 55% and 410 EFU/kg DM were ascertained for seed straw. The protein digestibility for hay and dried green fodder varied between 72.3 and 75.8%. Since there have been no reports lathyrogenous substances in the vegetative parts of flat pea, its use as green fodder or dried green fodder for feeding sheep, cattle or wild ruminants is possible.

Amino Acids↗
PubMed1982

[Surgical reduction of the kidney for inducing chronic kidney insufficiency].

By operative reduction of the renal tissue on 1/5 of both kidneys there are to be produced a chronic renal insufficiency in 21 black mini-pigs. The operative procedure was carried out at one time (nephrectomy and resection of the residual kidney) or at two times (in one group of it at first the nephrectomy and in the other group at first the resection of the kidney). Only 50% of the animals died with the symptom uremia in renal insufficiency. The nephrectomy--with a temporarily shifted resection of the residual kidney--effects the desired changes most approximately with very different reaction. This procedure appears as an animal model for the chronic renal insufficiency altogether not suitable.

Animals↗
PubMed1981

[Effect of copper status on reproductive performance and milk yield of female cattle in two copper deficient habitats. Effect of supplemental copper feeding on copper status].

The influence of a nutrition poor in Cu on the copper status of dairy cows was investigated with and without Cu-supplementation through the mineral mixture typical of the territory and enriched with Cu. The roughage produced in the territory investigated contained less than 8.0 mg Cu/kg and did not guarantee a Cu supply of the dairy cows meeting their needs. Feeding the mineral mixture rich in Cu improved the Cu-status of the dairy cows, did, however, in one of the territories not result in a Cu-incorporation in the liver that meets the needs. Possibly the reason for this divergent behaviour is an oversufficient S- and Fe-supply. In contrast to this, the Cu-content of the cerebrum of the cows in both territories showed the effect of the Cu in the mineral mixture.

Animal Feed↗
PubMed1981

[Effect of the copper status on the reproduction performance and the milk yield of cows in 2 copper-deficient locations. 2. Effect of copper deficiency on the reproduction performance and the milk yield of cows].

The influence of copper deficiency on the reproduction performance of cows has not often been investigated. In two habitats feeding cows with mineral mixtures rich in copper resulted in a significant reduction of the aperiodically extended sexual cycles. The beginning of the first visible symptoms of heat, the period between gravidities, the duration of gravidity, the birth weight of the calves and the Cu-content of the colostrum remained uninfluenced by Cu-supply. The liver weight increase of the calves from cows without Cu-supplement during gravidity was by 5% lower during the first 90 days of life than that of the offspring of cows with additional intrauterine Cu-supply (p greater than 0.05). The mineral mixture increased the milk yield by 0.4 resp. 0.5 kg and the milk fat content by 0.10 resp. 0.13%. This resulted in an excess production of 32 resp. 62 g milk fat per cow and day of the experiment (p greater than 0,05).

Animals↗
PubMed1981

[Iodine metabolism. 2. Effect of iodine deficiency on reproduction and the development of progeny of goats and miniature pigs].

The influence of J-deficiency on reproduction was tested in model experiments with goats and mini pigs, partly through several reproduction cycles including the descendants after intra-uterine depletion as well. The effect of 0.05 mg J/kg dry matter in the concentrated feed (total ration 0.03)--0.04 mg J/kg dry matter) for goats was a diminished success of first inseminations, a higher frequency of abortions, high mortality and poorer development of the kids. All J-deficiency goats and kids suffered from hypertrophy of the thyroid gland, half of all J-deficiency kids were born hairless. Concerning the mini pigs, 0.06 mg J/kg dry matter even after intra-uterine depletion had no detectable influence either on conception or the mortality and development of the piglets. The thyroid gland of all deficiency pigs was enlarged, however. The hypertrophy of the thyroid gland makes it easy to diagnose J-deficiency visually.

Abortion, Spontaneous↗
PubMed1980

[Investigation of iodine metabolism. 1. The influence of iodine deficiency of the feed consumption and the development of the live weight of goats and dwarf pigs].

With goats and dwarf pigs two experiments were made with semi-synthetic rations. The influence of insufficient (0.05 resp. 0.06 ppm) and sufficient (0.42 resp. 0.56 ppm) supply with iodine on feed consumption and the development of the live weight during the growth period and gestation was investigated. While iodine deficiency resulted in diminished feed consumption and a growth depression of the goats, a negative influence on feed consumption and the live weight increase of the dwarf pigs could not be detected, feed expenditure per kg weight increase, however, was distinctly higher.

Animals↗
PubMed1979

[The effect of chronic renal insufficiency with and without dialysis therapy on the manganese content of various human organs].

On the basis of the organ values of nine decreased, formerly with Al (OH)3 treated patients with renal insufficiency without dialysis and 15 patients with dialysis their Mn-state was investigated in comparison to 60 control persons comparable as to age and sex. The dialysis patients for a considerable part died of the so-called dialysis encephalopathy three to five years after the beginning of the Al-treatment. In all investigated nine organs with the exception of the blood of the dialysed patients (liver, hair of the head, myocardium, brain, rib, lung and testicle) the Mn-content was, in comparison to the control persons, essentially, partly highly significantly reduced. These findings were discussed in various kinds of animals in connection with the skeletal and nervous disturbances conditioned by the Mn-deficiency. It may not be excluded that the Al-hydroxyde used for the phosphate binding protects also another essential trace elements and particularly Mn from resporption and has an antagonistic influence on the Mn-metabolism, respectively. Animal experiments must clarify the complex mentioned.

Age Factors↗
PubMed1979

[The supply of wild ruminants with major and trace elements. 1. The cadmium content of winter grazing and the cadmium status of red deer, fallow deer, roes and moulons].

The Cd-determination of 10 different winter grazings for wild ruminants in seven different biotopes showed significant differences of the habitats resulting from the previous Cd-emission of metallurgy smelting non-ferrous metals. The winter grazing of the Tharandt Forest and the Harz mountains contained significantly more Cd than that of the Lower Flaming hills, the western Erzgebirge and the northern agrarian areas. The bark and the tips of conifer twigs, twigs of oak and mountain ash, bilberry and heather plants, i. e. perennial plants resp. parts of plants proved to be particularly rich in Cd. On an average, wild ruminants consume more Cd than domesticated ruminants, which do not consume parts of perennial plants. The rumen contents of all wild ruminants contained, with 0.20 to 0.25 mg/kg dry matter more Cd than could be expected from the content of the grazing. In the Cd-contaminated areas the amount of Cd in the rumen contents too showed the Cd-load. The kidneys, livers and the covering hair of a total of 172 head red deer, roes and mouflons reflected the Cd-load and the dependence of the Cd-level on the age. The Cd-concentration ascertained in the organs of the wild ruminants was compared with that of sheep and cattle. The, on an average, higher Cd-load of the wild ruminants was confirmed. The kidneys of wild ruminants older than five years should, as a general principle, not be eaten and neither should the livers of animals from Cd-contaminated biotopes. The limb defects of mouflons from Cd-contaminated areas are discussed in connection with Cd-induced secondary Cu-deficiency resp. Mn- and Zn-deficiency. A reference is made to further works.

Animal Nutritional Physiological Phenomena↗
PubMed1979

[The supply of wild ruminants with major and trace elements. 2. The manganese content of winter grazing and the manganese status of red deer, fallow deer, roes and mouflons].

The winter grazing of wild ruminants on mantles of slate waste in the Harz mountains and in Gera county were richest in Mn whereas those on mantles of granite waste in the Erzgebirge were poorest. The flora of the shell-limestone, keuper and loess areas contains much less Mn than that of those acid habitats. The Mn-requirement of the wild ruminants grazing in the forests is met however, since bilberry plants (2,080 mg/kg), spruce twigs (984 mg/kg), spruce bark (827 mg/kg), oak twigs (791 mg/kg) and heather (754 mg/kg dry matter) in addition to many other plant species store extremely high amounts of Mn. Solely sallow twigs were poor in Mn (28 mg/kg). Based on 601 samples examined, the Mn supply of wild ruminants is extensively described. The rumen content reflected the plentiful Mn-supply of the wild ruminants living in forests (greater than 400 mg/kg) and the far worse one of field roes, particularly in Mn-deficiency areas for domesticated ruminants (mantle of shell-limestone waste 37 mg Mn/kg dry matter of rumen content). The indicator organs of the Mn-status (liver, covering hair, kidneys) verify the statements made concerning red deer, fallow deer and mouflons, of which a total of 170 head from 14 biotopes were examined. An Mn-deficit of field roes in Mn-deficiency habitats in winter cannot completely be excluded. Mouflons have not yet been able to adapt themselves to the excessive Mn-supply of the acid forest habitats in Central Europe. They stored significantly higher amounts of Mn in liver, covering hair, kidneys, cerebrum and ribs than the other wild ruminants and sheep and cattle. The normal Mn-content of the liver and the cerebrum of red deer, fallow deer and roes corresponds to that of sheep and cattle. Roes and fallow deer have winter covering hair poor in Mn (less than 4.0 mg/kg) in comparison to sheep and cattle.

Animal Nutritional Physiological Phenomena↗
PubMed1978

[Nickel--an essential trace element. 3. Effect of nickel deficiency on reproductive performance in female animals].

A total of 26 Ni-deficient (less than 100 ppm Ni in the ration) breeding goats and their 30 kids and 24 corresponding control goats with 37 kids were used to investigate, over 6 experimental years, the influence of Ni-deficiency on the reproductive performance until weaning. Following the same arrangement, 7 and 6 mini sows, respectively, and their piglets (71 and 67) were studied. The following statistically secured results were obtained. Ni-deficiency resulted in reduced pregnancy rates (after one insemination) in animals that had revealed clear estrus symptoms. This caused delayed pregnancies and birth of offspring. The conception and abortion rates, the number of offspring and the sex ratio were not influenced significantly by Ni-deficiency. Intra-uterine Ni-deficiency reduced the birth weights and caused lower weight gains during the suckling period. Its influence proved stronger in the kids as compared to the mini piglets. Ni-deficiency caused the mortality of the offspring during the suckling period to increase significantly. The losses in the Ni-deficient kids and mini piglets were by 41 and 51%, respectively, higher than in the corresponding control animals.

Abortion, Veterinary↗
PubMed1978

[Excessive iron administration to sheep. 2. The effect on the iron, copper, zinc and manganese level in different organs].

Lambs received 250, 1000 and 1750 mg Fe per kg concentrate dry matter. The Fe-supplementations caused the Fe-levels of spleen, liver, kidneys and ribs to rise significantly. Liver and spleen reflected most markedly the high Fe-supply. The Fe-supplementation reduced the Cu-content in the liver and the share of Zn in the kidneys. The Mn-content of all body parts analysed was not significantly influenced by Fe-supplementation.

Animals↗
PubMed1978

[Effect of a calcium-deficient, phosphate- or ammonia-rich diet on the development and mineral metabolism of growing miniature pigs].

The metaphylaxis of renal calculi in form of partial withdrawal of Ca and the nutrition rich in phosphate or NH4C1 in children was disputed and not ascertained by animal experiments. For this purpose growing female dwarf pigs got a semisynthetic ration with 1 g Ca and 23 g P, respectively, or 15 g NH4C1 per kg dry feeding mass during 168 days. The dwarf pigs fed poor in Ca had a reduced increase of body-weight of 30%, the pigs fed rich in P and NH4C1 a reduced increase of body-weight of 11 and 16%, respectively, compared with the control dwarf pigs. The feeding regime chosen has no significant influence on the Ca-, P-, Cu-, and Mn-state of the dwarf pigs (alpha greater than 0.05). Only the animals with deficiency of a Ca statistically ascertained stored more Zn in the liver than the control animals. The applied NH4C1 as well as the medicament Ammonchlor SSW contained traces of Cd. Concerning the lacking significant changes of metabolism on account of the retardation of growth conditioned by therapy it cannot be concluded that there is possible a metaphylaxis of the lithiasis in children by partial withdrawal of Ca or additions of P and NH4C1, respectively.

Ammonia↗
PubMed1977

[Nickel--an essential trace element. 1. Influence of the supply of nickel on live weight gains, food consumption and body composition of growing pigs and goats].

Pigs and goats were used in long-term trials to investigate in which way supplements of 100 mug Ni per kg of a semisynthetic diet (control rations: 10 mg Ni per kg of the diet) would influence the rate of weight gains and food consumption and the body composition of the animals. A significant decline in the rate of weight increase was noted in the Ni-deficient animals. Ni-supplements added to the diet (10 mg/kg) increased the weight gains by 21% (goats) and 13% (pigs). In the present trial goats showed a more sensitive response to Ni-deficiency than pigs. Ni-deficiency did not affect the food consumption of neither the growing goats nor the growing pits. It was only during their lactation period that the Ni-deficient goats showed a statistically well-established decrease in food consumption. The level of Ni supply did not affect the crude protein, crude fat and crude ash content of the pigs.

Animal Feed↗
PubMed1976

The substitution of protein feed by lysine-supplemented protein-rich wheat during the raisung and laying periods in hens. 6. Report. The effect of graded lysine supplemented on the crude nutritional content of the carcas of laying hens.

In the present work 8 hens taken from each of the 16 experimental groups (90 birds per group) were killed at the end of the trial period (52 weeks). The weight of the organs was determined and bones, the utilizable parts and the residual carcass were analyzed for their crude nutrient content. The experimental birds received rations containing a large proportion of high-protein wheat supplemented with varying levels of lysine. Variations in the lysine supply did not affect the mass of blood, feathers, bones, liver, stomach, heart and ovaries, including ovarian follicles. An analysis of the utilizable parts (flesh, stomach, heart, liver, follicles, fat) for crude nutrients showed that the heavier birds receiving adequate amounts of lysine contained less crude protein and more crude fat than the smaller birds. A positive correlation was found to exist between the crude ash content of these samples (expressed as %) and the levels of lysine supplied during the laying period. All the birds receiving the lysine-deficient ration during the time of rearing or during the laying period contained significantly less crude ash in their bones. Alongside with the crude ash content the phosphorus content of the bones decreased when the birds where fed the diet for laying hens.

Animal Feed↗