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Biomedical subjects

M Banarer

Publications and source records attributed to M Banarer.

6 recordsLinked to original sources
PubMed1982

Absolute and relative bioavailability of lithium dosage forms in the beagle dog.

The absolute and relative bioavailability of three dosage forms containing lithium salts was determined using the Beagle dog as a model in a single dose crossover design study. A difference in the half-life of elimination was observed between the i.v. and the p.o. routes of administration. No significant differences were found for the apparent volume of distribution between routes of administration and the tested dosage forms. The fraction of dose absorbed was 0.42 +/- 0.058 and 0.75 +/- 0.18 for p.o. solution and p.o. tablet, respectively.

Animals↗
PubMed1982

Lithium dosage regimen design by the repeated one-point method.

The applicability of the repeated one-point method for the design and adjustment of dosage regimen of lithium was studied in a crossover design experiment using the Beagle dog as a model. It was found that the steady-state concentrations reached after administration of the corresponding loading and maintenance doses were within the 95% confidence interval for the three previously selected levels of 0.6, 0.8 and 1.0 mEq/l. The good correlation observed between animal and published human data suggests that this model is a useful one for further pharmacokinetic studies on lithium.

Animals↗
PubMed1980

Analog computer monitoring and evaluation of a dosing nomogram for gentamicin based on the c'min-method: Part I.

Present methods for dosing gentamicin are based on usual doses or desired peak concentrations. The effective range is believed to be between 3 and 10 micrograms/ml. A method is proposed to maintain the minimum steady state concentration at a desired MIC with peak concentrations not exceeding 10 microgram/ml. After determination of the log serum creatinine-log creatinine clearance relationship in a specific population group (Peruvian mestizos), a nomogram for dosing gentamicin was developed. The applicability of the nomogram or the corresponding equation upon which the nomogram was based was tested in patients for desired MIC of 0.5, 1.0, 1.5 and 2.0 microgram/ml, and the actual c'min values obtained were compared with predicted levels. Using a correction factor, the nomogram is applicable for the United State and European population. The importance of drug level monitoring is emphasized.

Computers, Analog↗
PubMed1980

Analog computer monitoring and evaluation of a dosing nomogram for gentamicin based on the C'min-method, part II.

Present methods for dosing gentamicin are based on usual doses or desired peak concentrations. The effective range is believed to be between 3 and 10 micrograms/ml. A method is proposed to maintain the minimum steady state concentration at a desired MIC with peak concentrations not exceeding 10 micrograms/ml. After determination of the log serum creatinine-log creatinine clearance relationship in a specific population group (Peruvian mestizos), a nomogram for dosing gentamicin was developed. The applicability of the nomogram or the corresponding equation upon which the nomogram was based was tested in patients for desired MIC of 0.5, 1.0, 1.5 and 2.0 micrograms/ml, and the actual c'min values obtained were compared with predicted levels. Using a correction factor, the nomogram is applicable for the United States and European population. The importance of drug level monitoring is emphasized.

Adolescent↗
PubMed1977

Computer-calculated kanamycin dosage regimen and monitoring.

The applicability of a computerized dosage regimen determination based on a recently developed method for drugs following the minimum inhibitory concentration pattern (bacteriostatic drugs) has been tested for kanamycin injected intramuscularly in 8 patients with varying degrees of renal impairment. The dosage regimens for maintaining a minimum therapeutic kanamycin concentration of 5.0 micron g/ml was determined with the Wang 700 C Computer. After the 1st, 2nd, 3rd, 6th, 9th, and 12th dosing interval blood samples were taken and the acual kanamycin serum concentrations determined. The expected multiple dose serum level curves for each patient were simulated using the Comdyna Dose Generator Analog Computer and the individual actual serum concentrations were monitored. The actually found serum level data were compared to the expected values based on the dosage regimen equations and to the steady state equations. Additionally, the expected peak maxima were calculated. The proposed method resulted in effective and safe kanamycin serum levels.

Adult↗