Lithium dosage regimen design by the repeated one-point method.

W A Ritschel; M Banarer

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PubMed · 7199926

Lithium dosage regimen design by the repeated one-point method.

W A Ritschel·M Banarer

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Abstract

The applicability of the repeated one-point method for the design and adjustment of dosage regimen of lithium was studied in a crossover design experiment using the Beagle dog as a model. It was found that the steady-state concentrations reached after administration of the corresponding loading and maintenance doses were within the 95% confidence interval for the three previously selected levels of 0.6, 0.8 and 1.0 mEq/l. The good correlation observed between animal and published human data suggests that this model is a useful one for further pharmacokinetic studies on lithium.

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W A Ritschel, M Banarer. 1982. Lithium dosage regimen design by the repeated one-point method.. https://pubmed.ncbi.nlm.nih.gov/7199926/

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