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M Bando

Publications and source records attributed to M Bando.

At least 55 records · Page 3Linked to original sources
PubMed1996

A clinical profile of corticobasal degeneration presenting as primary progressive aphasia.

We report a patient with primary progressive aphasia who first presented with amnesic aphasia that developed over the course of 3 years into nonfluent aphasia with buccofacial apraxia, followed in the next year by cognitive impairment and parkinsonism. Pathological findings were typical for corticobasal degeneration except for the distribution of cortical atrophy. This case suggests that corticobasal degeneration should be included in the differential diagnosis of primary progressive aphasia, especially in association with parkinsonism.

Aphasia, Primary Progressive↗
PubMed1996

Ferricyanide reductase activity in cataractous human lens.

We assayed ferricyanide reductase activity (one of NADH-dependent diaphorase activities) in the soluble and insoluble fractions of cataractous human lenses. Activity of this reductase in both the soluble and insoluble fractions tended to decrease in order of cortex > nucleus periphery > nucleus center, and it was suggested that a decrease of the reductase activity is closely correlated with lens protein aggregation, and to some extent associated with the development of nuclear sclerosis (coloration) and cortical cataract. Furthermore, insoluble fraction had very high specific activity per mg insoluble protein in cortex, and the activity decreased sharply with an increase in the level of insoluble protein. The reductase activity in the insoluble fraction may be also related to the metabolic activity of plasma membranes.

Aged↗
PubMed1996

[An autopsy case of late-onset chorea].

Senile chorea has been an ill-defined clinical entity because of the difficulty of differentiating it from Huntington's disease (HD) of late-onset type. The gene specific for HD has recently been found to contain an abnormal (CAG)n trinucleotide repeat which allows it to be differentiated from the other conditions. Our case of late-onset chorea was differentiated from HD by PCR. An 80-year-old man had experienced gradually increasing chorea of his tongue, arms and legs for 4 years, but had not exhibited character changes, mental symptoms or dementia. He died of pneumonia at 84 years. The pathological findings in this case were different from those of HD. The brain weighted 1220 g, and did not show striatal atrophy or neuronal loss. The most remarkable findings were numerous foamy spheroids scattered in the caudate and putamen and proliferation of fibrous astrocytes within the thin myelinated fiber bundles and in the neuropil. Similar findings were reported by Freidman et al. (1990). Although it is debatable whether this finding was responsible for the development of the chorea, this case should contribute to our understanding of senile chorea as a clinicopathological entity.

Age of Onset↗
PubMed1996

Evaluation of myocardial viability during simple cold storage with the use of electrical properties in broad frequencies.

BACKGROUND: The purpose of this study ws to determine whether myocardial viability during simple cold storage can be monitored from alteration of electrical properties of the preserved heart. METHODS: Twelve anesthetized dogs underwent rapid cardiac extirpation and were preserved in simple cold storage ( 4 degree C). They were divided into two groups according to preservation solutions. Groups S and U were preserved in saline and University of Wisconsin Solutions, respectively. The loss-tangent (Tan delta) in dielectric spectroscopy was analyzed on serial measurements of electrical properties of the preserved heart with an electrical impedance meter. Myocardial specimens were taken for myocardial adenosine triphosphate measurement with high-performance liquid chromatography and myocardial water content. We investigated the correlations among myocardial adenosine triphosphate, myocardial water content, and Tan delta. RESULTS: The maximum value of Tan delta corresponds to a frequency fT which ranged from 5 to 10 kHz in both groups and maximum Tan delta gradually decreased during preservation in both groups. Myocardial adenosine triphosphate in group U was significantly higher than that in group S. The ratio of measured adenosine triphosphate and maximum Tan delta to the preischemic values during preservation were expressed as percentage of adenosine triphosphate and percentage of maximum Tan delta. There was close correlation between myocardial percentage of adenosine triphosphate and percentage of maximum Tan delta during preservation in both groups. Myocardial water content in group S increased during preservation but did not increase in group U. There was no correlation between myocardial water content and percentage of maximum Tan delta during preservation. Tan delta function were used to characterize the electrical properties of biologic tissue and were clearly associated with ischemic histologic damage of tissues. CONCLUSIONS: Therefore measurement of electrical properties in broad frequencies of the preserved heart may be feasible as a monitor of graft viability in a minimally invasive method.

Adenosine↗
PubMed1995

[Coronary artery bypass grafting in cases with the atherosclerotic ascending aorta].

Among 172 cases of coronary artery bypass grafting, 9 cases (5%) revealed severely atherosclerotic ascending aorta. In 3 of the 9 cases, total aortic cross-clamping in the distal anastomoses of saphenous vein graft (SVG) and partial aortic clamp in the proximal anastomoses of SVG were performed. In 1 case with this technique, cerebral infarction was occurred. In 4 cases, total aortic cross-clamping in the distal and proximal anastomoses of SVG was performed. In 2 of these cases with this technique, cerebral infarctions were occurred. Hypothermic circulatory arrest was performed in 2 of the rest. In one case that was predicted to have atherosclerosis of ascending aorta prior to operation, the left internal thoracic artery was anastomosed to the left anterior descending, and SVG to the right coronary artery with hypothermia and ventricular fibrillation. And during the proximal anastomoses of SVG, hypothermic circulatory arrest without aortic clamping was initiated. In another case, atherosclerosis of ascending aorta was noted after aortic cross-clamping. Then the aorta was declamped, hypothermic circulatory arrest was established, the aorta was opened, the diseased segment was resected, and proximal anastomoses of SVG was performed to Dacron patch which was implanted for aortic wall. There were no cerebral infarction in last two patients.

Aged↗
PubMed1995

[Coronary artery bypass surgery in patients aged 75 years or older].

16 patients 75 years of age or older underwent coronary artery bypass grafting. The overall hospital mortality rate was 12.5% (2/16), 0% for elective procedures, 33.3% for urgent and emergent cases. 4 of 6 patients underwent emergency CABG after failed percutaneous transluminal coronary angioplasty. Major complications were altered mental status, low cardiac output syndrome (LOS), pulmonary dysfunction and renal dysfunction. One patient who died had LOS. Another patient who died occurred multiple organ failure after pulmonary dysfunction from self-extubation. There was no correlation the incidence of postoperative confusion and preoperative cerebral CT findings. CABG can be performed safely in patients 75 years or older, if the preoperative conditions are stable.

Age Factors↗
PubMed1995

[Hemorrhagic cerebral infarction at the old age in a case with familial antithrombin III (ATIII) deficiency].

An old woman had stroke at age 67. Cerebral CT scan disclosed the low-density lesion with high-density area in the left temporal lobe, but no empty delta sign in the superior sagittal sinus. Thereafter, she had sometimes panic attacks. At the age of 70, she was admitted because of loss of consciousness probably caused by the same attack. On admission, Brain CT scan showed no fresh lesions. During the stay in the hospital, she had an episode of deep vein thrombosis of her left leg. The patient was found to have not only reduced biochemical activity but also low immunological level of AT III. Her nephew had also the low plasma AT III antigen concentration. Transesophageal echocardiography showed no abnormality, but atherosclerotic change at the aortic arch. We speculated that hemorrhagic cerebral infarction in the territory of the branch of middle cerebral artery could be induced by the arterial thrombus which was related to the hypercoagulable state associated with familial AT III deficiency, although the possibility of cardiogenic embolic infarction or of cerebral vein thrombosis could not be ruled out. Familial AT III deficiency is one of the causes of cerebral infarction even in the elderly.

Aged↗
PubMed1995

Ascorbate free radical reductases and diaphorases in soluble fractions of the human lens.

Major and minor ascorbate free radical (AFR) reductases, with diaphorase activity, and three other diaphorases were separated from the human lens soluble fraction by DEAE-cellulose ion-exchange column chromatography. They were characterized for adsorptivity to ion-exchange and 5'AMP-Sepharose 4B affinity columns, kinetic properties, and substrate specificity. The latter diaphorases were closely correlated with NADH-cytochrome beta 5 reductase. The major and minor AFR reductases were regarded as a major diaphorase group different from two ubiquitous diaphorases, i.e., NADH-cytochrome beta 5 reductase and DT-diaphorase. A major AFR reductase was partially purified approximately 50 fold over the lens soluble fraction by ion-exchange, affinity, and gel filtration (Sephacryl S-200 HR) column chromatography. From the partially purified enzyme, 2 bands, one sharp and one diffuse, were obtained by native polyacrylamide gel electrophoresis. Two proteins, of 20 and 24 kDa, were identified in the active enzyme bands by SDS-polyacrylamide gel electrophoresis. This suggests that the 20 and/or 24 kDa proteins may be components of the major AFR reductase.

Chromatography, Affinity↗
PubMed1994

Crystal structural analysis of tobacco necrosis virus at 5 A resolution.

X-ray diffraction intensities for tobacco necrosis virus crystals were collected at 5 A resolution using a Weissenberg camera with a large cassette of radius 430 mm. The synchrotron radiation source at the Photon Factory was used. The crystal structure of the virus was obtained by 91 cycles of the non-crystallographic symmetry averaging. Secondary structures such as alpha-helices and beta-structures were clearly identified in the electron-density map at 5 A resolution. This virus resembles southern bean mosaic virus both in orientation of coat protein subunits and in their folding. Ordered and disordered parts of each subunit of tobacco necrosis virus are shorter and longer than the corresponding parts of the southern bean mosaic virus by 12 and 27 residues, respectively.

Journal Article↗
PubMed1994

Structure of [2Fe-2S] ferredoxin I from Equisetum arvense at 1.8 A resolution.

Ferredoxin I (Fd I) from Equisetum arvense is an iron-sulfur protein composed of 95 amino-acid residues and one [2Fe-2S] cluster. It crystallized in the space group P2(1), a = 30.4, b = 57.4, c = 47.5 A and beta = 78.7 degrees with two molecules per asymmetric unit. X-ray diffraction data up to 1.8 A resolution were collected by using a Rigaku four-circle diffractometer. The initial model of Fd I, which was derived by the molecular replacement method using a structure of the Fd I from the blue-green alga Aphanothece sacrum, was refined by molecular dynamics simulation and a least-squares minimization with stereochemical restraints. Positional parameters and isotropic temperature factors for 1420 non-H protein atoms and 183 water molecules were refined on 13 838 observed structure factors (F(o) > sigma(Fo)) between 10.0 and 1.8 A resolution. The final Rfactor was 17.0%, and the standard deviation of atomic position estimated by Luzzati plot [Luzzati (1952). Acta Cryst. 5, 802-810] was 0.2 A. The electron-density map was well defined for the two independent molecules except for the N-terminal residue and the three C-terminal residues. Equivalent Calpha atoms of two independent molecules in the asymmetric unit were superposed by the least-squares method with root-mean-square deviations of 0.26 A. Reasonable structural differences were observed at a polypeptide segment having few intramolecular interactions. Highly flexible regions of the molecule were assigned from the structural differences between the two independent molecules in the crystal and the distribution of temperature factors along the polypeptide chain.

Journal Article↗
PubMed1994

Soluble ascorbate free radical reductase in the human lens.

A major and a minor ascorbate free radical (AFR) reductase were separated from the soluble fraction in the human lens cortex by DEAE-cellulose ion-exchange column chromatography. These AFR reductases also exhibited diaphorase activity using dichlorophenolindophenol and ferricyanide as electron acceptors. The major AFR reductase was partially purified by 5'AMP-Sepharose 4B affinity column chromatography. This partially purified AFR reductase showed a single band of diaphorase activity in native polyacrylamide disc gel electrophoresis. This activity band corresponded to the major protein observed in protein staining by Coomassie Brilliant Blue. However, the protein staining by Coomassie Brilliant Blue showed this activity band surrounded by diffused staining. Molecular weight of the partially purified AFR reductase was determined to be 32 kDa by gel filtration, and the apparent Km value for AFR was about 15 microM. This major lens AFR reductase could be distinguished from soluble Neurospora, Euglena and cucumber AFR reductases, and from two ubiquitous enzymes with reduction activity of AFR and/or foreign compounds, ie, NADH-cytochrome b5 reductase and DT-diaphorase, by their molecular weights, Km values and/or ion-exchange chromatographic behaviors.

Adult↗
PubMed1994

[Adult-onset dementia with abundant neurofibrillary tangles resembling progressive supranuclear palsy].

We described an autopsy case of 79-year-old woman with clinically unclassified senile dementia. The patient developed forgetfulness at the age of 73, and later, persecution mania, apathy and episodic stupor, but no extrapyramidal symptoms. Neuropathological examination revealed severe neuronal loss and gliosis of substantia nigra, moderate neuronal loss and marked grumose degeneration of dentate nucleus, and mild astrocytosis of subthalamic nucleus. Abundant neurofibrillary tangles (NFT) were observed in subthalamic nucleus, globus pallidus, substantia nigra, locus ceruleus, tegmentum of brain stem, pontine nucleus, inferior olive, and dentate nucleus. Gallyas silver impregnation method showed a wide distribution of argyrophilic grains and threads in cerebrum, brain stem and cerebellum. Although absence of clinical and neuropathological hallmarks excluded the diagnosis of progressive supranuclear palsy (PSP), the distribution of NFT and argyrophilic grains in this patient resembled PSP.

Age of Onset↗
PubMed1994

[Breast reconstruction--some refinements of TRAM flap procedure].

Since 1982, there have been many outstanding reports by Hartrampf, Dinner and others about the TRAM (transverse rectus abdominis m- c) flap. This procedure is now recognized as one of the best reconstructive armamentarium. Authors also have performed reconstruction by this flap over the past 13 years for 150 cases of chest wall defects and breast deformities with very good results. Through these experiences and studies in cadaver dissection, the authors are convinced that the blood supply of TRAM flap is enough with medial approximately 3/5 muscle as a pedicle, and the lateral 2/5 part of muscle can be preserved with the intercostal nerve innervation intact. The weak point of the TRAM flap is the unstable blood supply of the contralateral portion of skin island (Hartrampf's zone 4). Thus, the authors have been making the flaps with double narrowed pedicle, in cases where a large amount of tissue graft is indispensable. We have performed these refined TRAM flap procedures in 44 cases from 1990. Among the numerous advantages, for example, is the fact that synthetic material is never required to obtain a stable abdominal wall, and TRAM x 2 type flaps are very useful, especially in cases with scars in the lower abdomen that were previously thought to be contraindications for TRAM flap. No disadvantage was observed in these refined TRAM flap procedures.

Breast Neoplasms↗
PubMed1994

[A case of sarcoidosis with elevated SCC antigen in the serum and broncho-alveolar lavage fluid which was difficult to distinguish from lung cancer].

A case of sarcoidosis with a high level of SCC antigen in the serum and broncho-alveolar lavage fluid (BALF) which was difficult to distinguish from lung cancer is reported. A 66-year-old female was admitted with a fever, sputum and coughing. Chest X-ray on admission showed bilateral hilar swelling and infiltrative shadows in the left lower lung. Chest CT showed bilateral lymph node enlargement and a localized nodular mass. The level of SCC antigen in the serum and BALF was high. Initially she was suspected of having lung cancer, but she was subsequently diagnosed as having sarcoidosis from a bronchial biopsy specimen, BALF and gallium scintigraphy. It was difficult to distinguish this case showing lymph node enlargement and mass shadow from lung cancer. Although this is a rarely reported case of sarcoidosis with a high level of SCC antigen in the serum and BALF, it is possible that SCC antigen may be elevated in patients with benign inflammatory lung disease due to various interactions of cytokines.

Aged↗