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Biomedical subjects

M Bando

Publications and source records attributed to M Bando.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Experiences of breast reconstruction following mastectomy in cases of cancer and evaluation of psychological aspects of the patients].

The breasts are one of the symbols of femininity. Even if it is for the treatment of cancer, the loss or deformity of the breast brings a considerable psychological burden in addition to the physical pain. Authors have performed breast reconstruction on 150 cases during the past fifteen years and have obtained largely favorable results, which were already reported in several papers. Authors administered questionnaires to these patients in order to ascertain their candid opinions which are often not expressed in a hospital. The results of the survey are presented in this report. The survey was conducted anonymously and the questions were all multiple-choices. Approximately 82% of the patient responded. About the pain, inconvenience and motives for undergoing reconstruction, there was a wide variety of answers and many of those surprised authors. For instance; hesitant to go to a hot spring, or on a trip with friends (76%), hesitant to go to a clinic or a hospital for physical check-ups and common illness (74%), troublesome to wear special underwear (69%), inconvenient because ordinary clothes cannot be worn (56%), distressed when viewing own body (52%), unable to dress in thin clothes in hot summer season (50%), imbalance of the breasts (49%), inconvenient to participate in sports (47%). The most patients experienced inconveniences in daily life and had mental and emotional problems. Overall, an impression of the results of breast reconstruction was 83% satisfactory or near satisfaction. About the condition after reconstruction: Patients also expressed a wide variety of opinions about the improvements. For instance, they are relieved from the troubles of wearing special clothing and enjoy selecting and shopping for clothes. They are able to walk on the street with dignity. They enjoy hot spring baths, sports, and leisure activities. They can go for physical check-ups without hesitation. They have a sense of liberation, and become free from constant anxiety. They developed again a forward-looking and positive attitude. Some patients say that they forgot that they had breast reconstruction and that they had breast cancer. As for marriage after reconstruction, which seems to be author's ultimate goal, 12 of the 52 single women have married, and another 22 are currently planning to marry. To the question, "If you are consulted by someone who is in a similar situation". 99% said they would recommend the reconstruction.(ABSTRACT TRUNCATED AT 400 WORDS)

Breast↗
PubMed1990

[Coronary artery disease in patients with abdominal aortic aneurysm].

Selective coronary angiography to determine the prevalence of coronary artery disease (CAD) has been performed in patients with abdominal aortic aneurysm (AAA). Thirty patients in this series consisted of 26 men and 4 women with an age range of 48-87 years (mean +/- SD: 67.5 +/- 8.2 years). As the atherosclerotic risk factors, cigarette smoking was present in 19 patients (63.3%), hypertension was in 18 (60%), hypercholesteremia was in 10 (33.3%), and diabetes mellitus was in 2 (6.7%). Cerebral vascular disease was present in 11 patients (36.7%). Regarding CAD, angina pectoris or old myocardial infarction was found in 9 patients (30%), and abnormal electrocardiography (ECG) was in 16 patients (53.3%). Coronary angiography prior to operation of AAA was performed to 22 patients (73.3%), and 15 patients (68.2%) among them had significant coronary artery stenosis, and 9 patients underwent myocardial revascularization (4 CABG, 5 PTCA). CAD was frequently complicated both in patients without symptoms or ECG abnormalities and in less than 65-year patients. In order to prevent fatal myocardial infarction, we recommend routine coronary angiography to patients with AAA. And if necessary, myocardial revascularization must be indicated prior to aneurysmectomy.

Aged↗
PubMed1990

[A case of myonephropathic-metabolic syndrome after urgent aortic valve re-replacement due to prosthetic valve thrombosis].

Acute cardiac failure due to prosthetic valve thrombosis is a rare, but lethal complication after cardiac valve replacement. A 40-year-old female admitted to our hospital, because of cardiac failure after aortic valve replacement with a #21 Björk-Shiley valve in 1975. After admission, echocardiography showed thrombotic obstruction of the prosthetic valve, and we underwent urgent aortic valve re-replacement. Postoperative period, she was complicated with myonephropathic-metabolic syndrome (MNMS). But, we performed intermittent veno-venous hemofiltration (IVVH) in early period, and successfully could save her life and her lower limb.

Adult↗
PubMed1989

Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.

A 63-year-old man with hypothyroidism is described. He had been receiving L-thyroxine therapy following mitral valve surgery. About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression. Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy. Emergency selective coronary angiography was performed. Comparing his coronary angiograms with those obtained before surgery indicated a severely spastic left coronary artery. We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.

Angiography↗
PubMed1989

Chronic effects of nicorandil on exercise tolerance in patients with stable effort angina pectoris.

To examine the chronic effects of nicorandil, a new coronary vasodilator, on exercise tolerance, we gave this drug for ten days at 15 mg/day orally in three divided doses to 10 patients with stable effort angina. An increase in exercise capacity by more than 1 stage of modified Bruce's protocol was observed in 6 of 10 patients on the 5th and 10th day after the administration. The exercise duration was significantly prolonged from 294 +/- 86 sec (mean +/- SD) before the administration to 363 +/- 106 sec and 405 +/- 139 sec on the 5th and 10th day after the administration, respectively. With nicorandil administration, the time to 0.1 mV of ST-segment depression was also significantly delayed from 3.1 +/- 1.9 minutes to 4.5 +/- 2.6 minutes on the 10th day. On the other hand, systolic blood pressure, heart rate and pressure rate product did not demonstrate any significant change before and after the administration. These results indicate that oral nicorandil of 5 mg 3 times a day can chronically increase exercise tolerance without decreasing myocardial oxygen consumption in patients with stable effort angina.

Adult↗
PubMed1989

[A case of auditory agnosia with the lesion of bilateral auditory radiation].

A 53-year-old man showed central auditory disturbance with recurrent cerebral hemorrhage. At his acute stage he had deafness and auditory anosognosia. Two or three months later, there was no deafness and auditory anosognosia, but he could not comprehend words, environmental sounds and music. Auditory brainstem responses showed no peripheral or brainstem damage, and the lesion of bilateral auditory radiation was detected by MRI. His auditory agnosia did not improve over one and a half year. There is no report like such permanent auditory agnosia with the lesion of bilateral subcortical temporal lobe.

Agnosia↗
PubMed1989

Calcium-induced opacification of rat lens beta-crystallin solution: its susceptibility to H2O2 oxidation.

Isolation of alpha, beta and gamma-crystallin solutions from rat lens soluble fraction was carried out by DEAE-cellulose ion-exchange column chromatography, and the effects of H2O2 on calcium-induced opacification of these solutions was examined. The alpha-crystallin solution became turbid in the presence of 1-10 mM calcium ions, and the turbidity increased with increasing calcium concentrations. The opacification level of the alpha-crystallin solution was not affected by 200 microM H2O2 treatment for 24 hours. On the other hand, the calcium-induced turbidity of a solution of beta-crystallin not treated with H2O2 was about one-third that of the alpha-crystallin, but by the H2O2 oxidation, its calcium-induced opacification was remarkably accelerated beyond the opacification level of the alpha-crystallin. The gamma-crystallin solution was made turbid by the H2O2 oxidation, but its turbidity was changed little by the addition of calcium ions. From the above results, it is suggested that the H2O2 acceleration of calcium-induced opacification of whole soluble lens protein solution previously reported might be mainly due to the aggregation properties of beta-crystallin. Furthermore, it is proposed that in the whole soluble lens protein, the calcium-induced aggregation of alpha-crystallin might be kept at almost the same low level whether the H2O2 treatment is done or not, and that the beta-crystallin might be more susceptible to H2O2 than the alpha- and gamma-crystallins.

Animals↗
PubMed1989

[The results of an investigation of the various factors influencing the late patency ratio of coronary bypass grafting].

The purpose of this communication was to find out the factors influencing the late patency ratio of coronary artery bypass grafts of 42 patients in our institution. The following results were obtained: 1. The size of the measured diameters of coronary arteries and the graft flow rates were correlated well to the late patency ratio (p less than 0.05). 2. The regular physical exercise trainings were significantly important to keep patent grafts (p less than 0.01). 3. In blood serum studies, serum uric acid levels were significantly lower (p less than 0.05), the average mean HDL cholesterol levels were much higher (p less than 0.001) and the ratio of total cholesterol to HDL cholesterol were significantly lower in the group with late patent grafts than with grafts occluded. Therefore, we found out the variables affecting graft patency ratio which were examined by a stepwise method were the diameter of the coronary artery, regular physical exercise training, the average of lower serum uric acid levels and higher HDL cholesterol levels. The multiple coefficient for these four variables was 0.562 (p less than 0.001) and the contribution was 31.6%. According to the base of this studies, we have concluded that postoperative regular physical exercise, low fat and restricted calorie intake were very important to keep the late patent grafts in long-term follow up period after coronary bypass surgery.

Adult↗
PubMed1988

Ascorbate free radical reductase and ascorbate redox cycle in the human lens.

The presence of ascorbate free radical (AFR) reductase (NADH:AFR oxidoreductase, EC 1.6.5.4) in senile cataractous human lenses was demonstrated by measuring spectrophotometrically NADH oxidation in the presence of ascorbate plus ascorbate oxidase. About 80-85% of the lens AFR reductase was probably recovered in the supernatant of the lens homogenate. Michaelis constants of the reductase were about 10 microM and less than 1 microM for AFR and NADH, respectively. We also showed that AFR reductase activities in the cataractous lenses tended to decrease with increase of insoluble lens protein contents, or showed rather the possibility that the reductase activity may have decreased before the lens protein aggregation. In the highest activity group (about 120-160 nmol NADH oxidized/min/lens), it was roughly calculated that the reductase in the lens could re-reduce immediately the total (or almost total) amount of AFR produced there by ascorbate oxidation even at a high rate of 600-800 microM/min, if NADH concentration in the lens were sufficiently maintained. The above results suggested that AFR reductase in the human lens plays important roles in ascorbate regeneration of its redox cycle, and that activity loss of AFR reductase, as well as of superoxide dismutase, glutathione peroxidase and glutathione reductase, may be responsible for the oxidative changes in lens proteins with the development of senile cataracts.

Aged↗
PubMed1988

A Raman study of disulfide and sulfhydryl in the Emory mouse cataract.

Emory mice (EM) are genetically predisposed to late-onset cataract formation. Our early work has shown UV-exposure slightly enhanced the expected 2 SH----SS conversion of normal mouse lenses only in the cortical regions. There was essentially no difference in the disulfide profiles of the nuclear region between UV-exposed and control lenses. Since the first noticeable change in the Emory mouse is a hazy nucleus when a lens is examined in vitro, we wondered if cataractogenesis in this model is different from the UV-produced cataract. This question was answered by comparing the visual axis profiles for SH and SS in early EM cataracts and in clear lenses from age-matched controls. The sulfhydryl profiles show that the SH level of 8.5-month-old EM lenses is essentially the same as that of the controls. Likewise, the disulfide profiles show no significant difference. The results clearly demonstrate that EM lenses do not undergo accelerated disulfide production. Therefore for the EM lens, the early stage of cataract formation must involve factors other than just accelerated oxidation of protein SH or glutathione SH. Invest Ophthalmol Vis Sci 29:823-826, 1988

Aging↗
PubMed1987

Effects of physical exercise training on cardiac function and graft patency after coronary artery bypass grafting.

The effects of physical exercise training after coronary artery bypass grafting on recovery of cardiac function and graft patency were studied in 115 patients. The patients were divided into Group I (N = 60) with and Group II (N = 55) without a scheduled rehabilitation program. The rate of graft patency was 98% in Group I and 80% in Group II. After operation, the exercise cardiac index and stroke index were significantly higher in Group I than in Group II. The exercise stroke index increased significantly in Group I, but not in Group II. The variables affecting graft patency, examined by a stepwise method, included double product, cardiac index, stroke index, and left ventricular end-diastolic pressure during postoperative exercise conditions, and postoperative exercise training. The multiple coefficient for these five variables was 0.459 (p less than 0.01). Our findings suggest that physical exercise training should be started as early as possible after coronary artery bypass grafting to improve graft patency and recovery of cardiac function.

Cardiac Output↗