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Biomedical subjects

M Bende

Publications and source records attributed to M Bende.

At least 73 records · Page 4Linked to original sources
PubMed1985

The effect of topical phenylpropanolamine on nasal secretion and nasal airway resistance after histamine challenge in man.

The effect of topically administered phenylpropanolamine (PPA) on nasal secretion and nasal airway resistance (NAR) was evaluated in a placebo controlled double blind cross-over study in 10 healthy subjects. The nasal secretion was collected in hankerchiefs and weighed. NAR was measured by anterior rhinomanometry and the degree of nasal blockage, secretion and the number of sneezes were registered in a score. PPA (25 mg/ml) significantly reduced nasal secretion, NAR and the degree of blockage and so PPA may be useful as a topical nasal decongestant.

Administration, Intranasal↗
PubMed1985

A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis.

Forty patients suffering from allergic conjunctivitis, due to birch pollen, participated in a double-blind parallel group comparison between levocabastine (a potent new specific histamine (H1) antagonist) and placebo, both given as eye drops. Symptom scores were recorded during a 4-week period. A 1-week run-in period was followed by a 3-week treatment period. To enable a fair evaluation of the treatment effect on the ocular symptoms only, all patients were treated with topical nasal glucocorticoids for possible rhinitis symptoms during the whole study period. Plasma levels of levocabastine were determined in all subjects at the end of the 3 weeks' treatment period. Pollen counts for birch pollen were followed simultaneously. The evaluation of the symptom score cards revealed a significant reduction of ocular symptoms following use of the active compound. The resorption of the active substance through the conjunctiva was low. In accordance with the present trend of more topical treatment for allergic rhinitis, levocabastine may constitute a valuable compound for the topical treatment of allergic conjunctivitis.

Adolescent↗
PubMed1985

Nasal mucosal blood flow in atrophic rhinitis.

Among many theories about the etiology of atrophic rhinitis with ozena, a reduced mucosal blood flow has been suggested, possibly caused by 'sympathetic spasm'. The nasal mucosal blood flow has been investigated in 6 patients with this disease before and after topical administration of a sympathomimetic drug. No difference in action compared to healthy subjects was found. Other pathophysiological mechanisms must be searched for.

Aged↗
PubMed1985

Treatment of perennial secretory rhinitis.

Patients with a history of nonallergic perennial secretory rhinitis of many years' duration were selected for a comparative study investigating the effects of the topical application of ipratropium (an anticholinergic drug) and budesonide (a glucocorticoid). According to the patient's daily registration of nasal symptoms, there was a significant effect of budesonide on nasal secretion and sneezes. Since budesonide proved superior to ipratropium, it is concluded that the secretion in this type of rhinitis might be regulated by mechanisms other than cholinergic.

Administration, Topical↗
PubMed1985

Vascular effects of phenylpropanolamine on human nasal mucosa.

The duration of the decongestant effect of phenylpropanolamine 2.5% as nose drops as well as the effect of the drug on nasal mucosal blood flow was studied in man. The nasal patency was significantly improved for up to three hours in patients with nasal congestion, while no effect on nasal mucosal blood flow was achieved. These results were discussed in relation to other more long-lasting nose-drops with blood flow-reducing effects.

Adolescent↗
PubMed1984

Leukotriene D4 increases nasal blood flow in humans.

The effect of leukotriene D4 on the nasal mucosal blood flow in humans was measured using a laser doppler flow meter. The leukotriene solution was applied topically to the nasal mucosa in 9 healthy subjects, and changes in blood flow were measured non-traumatically by the laser doppler instrument. The response showed a consistent increase in blood flow. A dose-response was found in the range of 0.063 - 4.0 nanomole. These results confirm an earlier study on the human skin, implicating leukotriene D4 as an important vasodilator in humans. No increase in nasal secretion was noted by the subjects tested.

Administration, Topical↗
PubMed1983

Effect of a topical glucocorticoid, budesonide, on nasal mucosal blood flow as measured with 133Xe wash-out technique.

The "vasoconstrictor" effect of dermally applicated steroids is a widely used parameter when determining the potency of glucocorticoids. A similar effect on the nasal mucosa has been suggested as providing an explanation for the clinical effect of topically administered glucocorticoids in the treatment of nasal disorders such as allergic and vasomotor rhinitis. The recently described 133Xe wash-out method was used for the purpose of blood flow determination in 11 healthy subjects. In a randomized double-blind cross-over study, the effect of topically administered budesonide, a non-halogenated glucocorticoid, for 1 week was compared with that of placebo. No difference was found to occur in the mucosal blood flow after the administration of budesonide, as compared with placebo. It seems likely that a more complex activity than vasoconstriction is responsible for the clinical effect in the treatment of nasal disorders, and further research is required in order to clarify this issue.

Administration, Topical↗
PubMed1981

Human ceruminous gland innervation.

Human ceruminous glands have been examined for the presence of adrenergic nerves using the histofluorescence method according to Falck and Hillarp, and immunohistochemistry for the presence of peptidergic nerves. The effect of adrenaline, alpha- and beta-blockers have been tested in vivo. No adrenergic or peptidergic nerves could be seen innervating the ceruminous glands. In spite of that, the glands reacted to local administration of adrenaline. This adrenaline effect could be blocked by alpha-blockers but not by beta-blockers. The cerumnious glands seem to possess alpha-adrenergic receptors, possibly capable of reacting with circulating catecholamines.

Adrenergic Fibers↗
PubMed1979

Vasopressin for bleeding from the head and neck.

Excessive bleeding from the head and neck sometimes presents a therapeutic problem. Ten patients with this type of haemorrhage have been treated with continous vasopressin infusion for 1-3 days. Haemostasis was quickly established in eight cases. No serious side effects were noted. Infusion of vasopressin has a rapid, beneficial effect on haemorrhage from branches of the external carotid artery.

Adolescent↗
PubMedDate not supplied

Nose drops induce vasomotion in the microcirculation of the sinus mucosa of the rabbit.

Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.

Administration, Intranasal↗
PubMedDate not supplied

Effect of local tranexamic acid gel in the treatment of epistaxis.

In patients with nosebleedings, the hemostatic effect of local application of tranexamic acid gel or placebo was compared in a randomized, double-blind, multicenter clinical trial with parallel groups. The times needed to arrest the initial bleeding were recorded, as well as any rebleedings within 10 days. The results showed no significant differences in any of the efficacy variables. Tranexamic acid was no better than placebo in the early treatment of nose bleedings, but the gel itself seemed to have a beneficial effect. The gel preparations were easy to insert into the nasal cavity and caused no discomfort to the patients.

Adult↗
PubMedDate not supplied

Olfactory threshold after nasal allergen challenge.

Olfactory threshold was investigated in patients with verified allergic rhinitis to birch pollen. In 20 patients the olfactory threshold was measured before and after challenge with topically applied birch pollen allergen during a non-symptomatic period. After provocation a statistically significant impaired detection sensitivity was found. The change in olfactory threshold was correlated with the measured amount of nasal secretions but not with subjectively or objectively registered nasal obstruction. A pronounced allergic reaction after allergen challenge is accompanied by an elevated olfactory threshold.

1-Butanol↗
PubMedDate not supplied

Adrenoceptors in the control of human nasal mucosal blood flow.

The blood flow in the human nasal mucosa is controlled by the functional state of the resistance vessels. This blood flow was studied by means of the 133Xe washout method. Using topical application of drugs that stimulate or block adrenoceptors, including clinical doses of nasal decongestants, we classified the adrenoceptors of the resistance vessels in the mucosa. The results suggest that stimulation of alpha2-adrenoceptors causes a reduction of nasal mucosal blood flow; stimulation of alpha1- and beta2-adrenoceptors seems to have no significant effects. Drugs that selectively stimulate alpha2-adrenoceptors, as well as those with preference for alpha1-adrenoceptors, cause nasal decongestion. To avoid the negative effects of a nasal mucosal blood flow reduction, it is suggested that a nasal decongestant with an alpha1-adrenoceptor stimulating effect should be preferable to a drug acting mainly on alpha2-adrenoceptors, provided that the decongestive effects are equal.

Adrenergic alpha-Agonists↗
PubMedDate not supplied

Influence of environmental temperature on human nasal mucosa.

Nasal mucosal blood flow and nasal patency were studied in seven healthy subjects in order to evaluate normal physiological reactions to cold and heat. Blood flow was measured by means of the 133Xe washout method, and nasal patency was determined by measuring maximal nasal expiratory air flow. In comparison with the results at room temperature (23 degrees C), there was a decreased blood flow and a decreased nasal patency after 20 minutes of exposure to cold (6 degrees C). After exposure to heat (40 degrees C), an unaltered blood flow and an increased nasal patency were registered. The results suggest that nasal patency is important for the conditioning of air and support the hypothesis that changes in nasal mucosal blood flow is engaged in body temperature regulation.

Adult↗