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Biomedical subjects

M Bielecki

Publications and source records attributed to M Bielecki.

At least 19 recordsLinked to original sources
PubMed2004

A comparative morphological study of direct nerve implantation and neuromuscular pedicle methods in cross reinnervation of the rat skeletal muscle.

PURPOSE: The study was undertaken to evaluate the recovery of rat skeletal muscles reinnervated by crossed direct nerve implantation and crossed neuromuscular pedicle graft. MATERIAL AND METHODS: The animals (157) were divided into 3 groups. In the first group--direct nerve implantation --(DNI) 52 animals, the peroneal nerve was transected and implanted into the gastrocnemius muscle of the hind limb of the rats. In the second group (53 animals)--the neuromuscular pedicle (NMP) of the peroneal nerve was elevated and transferred to the gastrocnemius muscle. The third group consisted of 52 healthy animals. Muscle function was examined by electrophysiological methods (evoked electromyography and muscle isometric tetanic tension) and by morphological methods (reinnervated muscle weight, microscopic examinations, morphometric and histochemical examinations). RESULTS: The weight of reinnervated muscles in the first 3 weeks decreased. The lowest values of muscle weights were noted at 4 weeks. At the end of the experiment muscle weight in the first group was 64.3% of the control group and in the second group 65.2%. Morphometric, histological and histochemical analysis were performed after 12 and 36 weeks. At 12 weeks of the experiment the diameter of reinnervated muscle fibers in the second group was statistically higher than in the first group. At that time the process of reinnervation was more advanced than in the first group. At 36 weeks there were no statistical differences between the two groups. An increase in the number of muscle fibers was noted as the processes of reinnervations progressed. At the site of nerve (or pedicled nerve-muscle) implantation new motor end plates were formed. CONCLUSIONS: We consider that reinnervation of the experimentally paralyzed muscle is possible after crossed DNI and after NMP neurotization. The reinnervation with the NMP technique is quicker than with the DNI. Based on the morphological examinations--both methods guarantee only a partial recovery of the function of the paralyzed muscle.

Animals↗
PubMed2004

Osteochondral defects of the talus treated by mesenchymal stem cell implantation--early results.

The purpose of this study was to present early results of talus cartilage defects treatment with autologous mesenchymal stem cells CD34+ implantation technique. Nine (9) patients were treated, due to IV degree chondromalation (by ICRS). The applied standard procedure included: clinical examination, AP and lateral x-ray, MRI, preoperative, as well as during control examination. The surgical procedure consisted of the defect's debridement, harvesting and fixation of the periosteal flap and CD34+ implantation. Clinical results were assessed after 6 months to 3 years by clinical examination, Magee score and MRI. Good and very good clinical results were obtained and confirmed by MRI in 8 cases. In one case, cartilage hypertrophy was noted. There were no delamination and infection signs.

Cartilage, Articular↗
PubMed2001

[Maternal plasma and amniotic fluid interleukin-6 and tumor necrosis factor-alpha levels in imminent preterm labor].

DESIGN: Our purpose was to investigate the maternal plasma and amniotic fluid interleukin-6 and tumor necrosis factor-alpha levels in women with imminent preterm labour. MATERIAL AND METHODS: The present study was designed to evaluate IL-6 and TNF-alpha levels in 93 pregnant women with threatened preterm labour and 40 women with normal pregnancy. Maternal blood samples were collected by routine forearm venipuncture at admission during routine laboratory tests. Amniotic fluid was collected through hysterectomy during caesarean delivery from women at term but not in labour and by amniotomy or hysterectomy from women with preterm labour. RESULTS: Maternal plasma and amniotic fluid IL-6 and TNF-alpha concentrations were significantly elevated in women with preterm labour (premature rupture of membranes and uterine contractions) compared to gestationally matched, non-labouring controls.

Amniotic Fluid↗
PubMed2000

[N-acetyl-beta-glucosaminidase (NAG) activity in parturients with placental insufficiency in postmature pregnancy and with EPH-gestosis].

NAG activity evaluation was carried out in parturients' blood and placental homogenates in regular pregnancies (n = 46) and complicated with biological postmaturity (n = 30) and EPH-gestosis (n = 24). It was revealed that in the blood of parturients with pregnancy complicated with gestosis there was considerable increase of NAG activity (2.43 +/- 1.02 microKat/kg). Lower activity level was found in parturients with entopic pregnancy (1.93 +/- 0.87 microKat/kg), and the lowest in those with postmature pregnancy (1.78 +/- 0.56 microKat/kg). The placental homogenates presented statistically significant differences--the highest in postmature pregnancy (6.37 +/- 2.01 mKat/kg), lower in pregnancy complicated with gestosis (4.85 +/- 1.52 mKat/kg) and the lowest in normal pregnancy (3.52 +/- 1.21 mKat/kg). The elevated activity in blood serum of parturient with gestosis may indicate kidney damage in the course of disease. High activity in homogenate may indicate the processes of placental degradation in postmature pregnancy. There is no evidence of correlation between NAG activity in blood and activity in placental tissue.

Acetylglucosaminidase↗
PubMed2000

[Maternal plasma and amniotic fluid interleukin-6 levels in imminent preterm labor].

Our purpose was to investigate the maternal plasma and amniotic fluid interleukin-6 levels in women with preterm labour. The present study was designed to evaluate IL-6 levels in 93 pregnant women with threatened preterm labour and 40 normal pregnant. Maternal blood samples were collected by routine forearm venipuncture at admission during routine laboratory tests. Amniotic fluid was collected during hysteretomy during caesarean delivery from women at term but not in labour and by amniotomy or hysteretomy from women with preterm labour. Maternal plasma and amniotic fluid IL-6 concentrations were significantly elevated in women in preterm labour (premature rupture of membranes and uterine contractions) compared to gestationally matched, non-laboring controls.

Amniotic Fluid↗
PubMed2000

[Efficacy of amnioinfusion in anhydramnios at term before induction of labor and newborn outcome].

Oligohydramnios complicates about 0.5-5% of pregnancies and is associated with an increased rate of perinatal morbidity and mortality. Our purpose was determine the effectiveness of amnioinfusion before induction of labour in reducing the incidence of fetal distress in pregnancies with anhydramnios at term. The rate of cesarean sections performed for fetal distress was higher in the control group (57.1%) than in the amnioinfused group (20.3%). Anhydramnios was associated with an increased abnormalities fetal heart rate. Amnioinfusion is effective option for the prevention of fetal distress in anhydramnios at term.

Adult↗
PubMed1999

[Epidemiological analysis of congenital infections in newborns].

The aim of this study was to review 2567 deliveries in the District Hospital in Białystok in 1997. In 2388 term labours and 179 preterm ones we noticed the congenital infections; in 90 (3.8%) and in 58 (32.4%) newborns respectively. The main etiologic factors of infections were Escherichia coli and Staphylococcus epidermidis in term newborns and Staphylococcus epidermidis and Escherichia coli in preterm babies. Clinical signs of the urinary tract infection were most frequent in mature infants, whereas the sepsis was quite common in premature newborns.

Bacterial Infections↗
PubMed1999

[The role of endothelium in normal pregnancy and pregnancy complicated by preeclampsia].

Endothelial cell dysfunction is thought to play a role in preeclampsia and the reduced production by vascular endothelial cells of the antiaggregatory and vasodilatory factors is well documented. The present study was designed to evaluate endothelial cells function in preeclamptic and healthy pregnant subjects. The nitric oxide plasma concentration in women with preeclampsia was significantly lower as compared with normotensive pregnant women. A significant increase in ET concentration was found in preeclamptic women as compared with normal pregnant patients and normal non-pregnant. The plasma concentrations of von Willebrand factor were significantly increased in healthy pregnancy as compared with preeclamptic patients. The results of our study demonstrate a significant endothelial cells damage in preeclamptic patients. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.

Adult↗
PubMed1999

[The role of nitric oxide and blood platelets in pathogenesis of preeclampsia].

The aim of this study was to evaluate the concentration of nitric oxide and the platelet function in preeclamptic and normal pregnant women. The patients with preeclampsia had new hypertension (diastolic blood pressure consistently > or = 90 mmHg with previously lower readings), new proteinuria and generalized oedema that subsequently regressed after delivery. Blood was collected by routine forearm venipuncture before delivery. The following parameters were evaluated: nitric oxide, beta-TG and PF4. The nitric oxide plasma concentration in women with preeclampsia was significantly lower compared with normotensive pregnant women. beta-TG and PF4 concentrations were significantly increased in patients with preeclampsia. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.

Adult↗
PubMed1997

[Pulmonary alveolar proteinosis--diagnostic problem].

A case of a 37 years old woman with suspicion of sarcoidosis is presented. However, the course of disease was not typical for sarcoidosis. The previous diagnosis was verified. The results of bronchoalveolar lavage and histological examination of lung biopsy sample revealed features characteristic for pulmonary alveolar proteinosis. The diagnostic methods, clinical course of disease and the ways of treatment are presented.

Adult↗
PubMed1997

[Meigs syndrome--diagnostic difficulties].

Meigs' syndrome in 68 years woman with pleural effusion and ovarian tumour was described. The cause of the pleural liquid in Meigs' syndrome is still not clear. New views on the pathogenesis and diagnostic methods of pleural liquids causes were presented.

Aged↗
PubMed1997

C-reactive protein concentration in the sera of pregnant women with imminent premature parturition and preterm amniorrhea.

C-reactive protein (CRP) levels were evaluated during spontaneous labour, in imminent premature parturition (IPP) and after preterm rupture of oocyst membranes (PROM). Increasing CRP level during spontaneous labour was found in 16.6% parturients. Elevated CRP level in patients with IPP makes it impossible to predict premature labour. In parturients with PROM, increase in CRP level makes further infection predictable only in a few cases.

C-Reactive Protein↗
PubMed1996

Activity alterations of chosen parameters of cord blood hemostasis in newborns from complicated pregnancies with premature ablation of placenta.

The study was carried out on 20 newborns with diagnosed premature ablation of placenta of 0,I,II clinical degree. In comparison to healthy newborns (n = 30) statistically significant differences were proved in: ATIII activity-48% (65%), plasminogen concentration-50% (63%), alpha 2antyplasmin activity 53% (67%); euglobulin clot fibrinolysis time 70 (95) min., and fibrinogen concentration 1.4 (1.8) g/l. The presented differences prove increased coagulation system activation in newborns from mothers with symptoms of premature ablation of placenta. Activity changes of hemostasis system in cases of premature ablation of placenta have the features of disorders accompanying intrauterine fetal anoxia.

Abruptio Placentae↗
PubMed1995

[Prophylaxis of puerperal infections using the Gyno-Pevaryl 150 preparation].

The authors estimated the biocenosis of vagina in women before delivery. The examination were made upon 50 women between 28 and 40 week of pregnancy and on the third day after delivery; comparing the results of estimation the purity of vagina and bacterial inoculations in two groups of pregnant women:-control group (without G-P 150 treatment) and in group with G-P 150 application. The authors proved the entire disappearance of mycotic infection (candida albicans) in women treated with G-P 150. The also stated that potential pathogenic bacterial flora during puerperium occurs much more rarely.

Antifungal Agents↗
PubMed1993

Complement levels of C4, C3C, factor B, and C1 inactivator in peripheral and retroplacental blood of parturient women with EPH gestosis.

The complement levels were determined in 54 parturient women with EPH gestosis, in 32 normal parturient women and in 24 normal non pregnant women. Complement components: C4, C3c, factor B /Bf/ and C1 inactivator /C1 INA/ were measured by radial immunodiffusion. Peripheral and retroplacental blood were examined. Concentrations of C4, C3c, Bf in peripheral blood of both groups of parturient women were significantly higher than in normal non pregnant women. Peripheral blood of parturient women with EPH gestosis contained significantly higher concentrations of C3c than in normal parturient women. Complement Bf levels of normal parturient women were lower in the retroplacental blood than in the peripheral. The levels of C4 were significantly decreased and C3c increased in the retroplacental blood of parturient women with EPH gestosis when results were compared with retroplacental blood of normal parturient women. Results of present study suggest that complement activation could contribute to the pathogenesis of EPH gestosis.

Complement C1 Inactivator Proteins↗
PubMed1993

Prognostic value of cardiotocographic acoustic test in post-term pregnancies.

The aim of the study was to evaluate the prognostic value of the acoustic test in post-term pregnancies. 80 acoustic tests were done (alkaline phosphatase and oxytocinase). In 12 cases, the cardiotocographic recordings of the acoustic test were described as incorrect, 11 neonates of this were born in asphyxia. In the group of neonates responding to the stimulus correctly, all neonates were born in a generally good state. The results show that the acoustic test is characterized by high prognostic value and a correct test result can predict a good fetal state.

Acoustic Stimulation↗
PubMed1992

The results of laminectomy and laminoplasty in cervical myeloradiculopathy.

The authors present the results of laminectomy and laminoplasty in 20 patients with cervical myeloradiculopathy according to the JOA score. Improvement was noted in 74% of the patients after laminoplasty and in 70% of the patients after laminectomy. On the whole decompression is a good method of treatment in this kind of disease.

Adipose Tissue↗