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Biomedical subjects

M Bielecki

Publications and source records attributed to M Bielecki.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Placental function in pregnant women with anemia].

The important finding in anemia of pregnancy is impairing hormonal placental function, certain complications of pregnancy and labor. Oxytocinase in the maternal serum was determined to evaluate placental function. Many authors pointed out the important role of the enzyme in biochemical monitoring of human pregnancy. 120 females at the III trimester of gestation were selected at random, but women with additional complications of pregnancy were excluded. Serum iron, total iron binding capacity, hemoglobin level, red blood cells count and hematocrit were assayed. Oxytocinase activity in different periods of gestation was compared to the earlier established normal values. It was found that iron deficit was associated with decreasing activity of the enzyme. It is concluded that there is impaired placental function in pregnancy anemia.

Anemia↗
PubMed1988

Attentional effects of caffeine in man: comparison with drugs acting upon performance.

The aim of this study was to observe if a method useful for measuring attentional effects could be applied in testing the differential effects of caffeine, the beta-stimulant salbutamol, and the beta-blocker propranolol. Caffeine (300 mg) was administered to a sample of 19 normal subjects compared to two samples of 40 controls. Caffeine was found to increase attention and vigilance by augmenting the number of repetitions of responses to a verbal stimulus in a free word association test. This pattern was also seen with salbutamol and propranolol, but to a lesser degree.

Albuterol↗
PubMed1987

Effects of naloxone on cardiovascular responses to static exercise and behavior in conscious cats.

Conscious cats performing static (isometric) exercise were studied before and after administration of the opiate antagonist naloxone in order to evaluate the possible role of endogenous opiates in regulating cardiovascular responses to static exercise. Intravenous administration (0.4 mg/kg) of naloxone had no effect on resting left ventricular systolic pressure or on heart rate. In addition, similar increases in left ventricular systolic pressure and heart rate occurred during static exercise both before and after naloxone. However, naloxone reduced the number of exercise events the cats would perform per day. We conclude that moderate doses of naloxone do not modulate the cardiovascular responses to moderate static exercise in conscious cats. The results do indicate that endogenous opiates are involved in regulating the number of exercise bouts the cats will perform per day.

Animals↗
PubMed1986

Effects of alpha-adrenergic blockade on cardiovascular responses to static exercise in cats.

Static exercise performed by conscious cats elicits increases in heart rate (HR), left ventricular systolic pressure (LVSP), and the maximal rate of left ventricular pressure development [LV(dP/dt)max]. The increased HR is mediated primarily by withdrawal of parasympathetic tone, whereas a beta-adrenergic mechanism is responsible for the LV(dP/dt)max increase. In the present study the cardiovascular responses to static exercise in awake cats was recorded before and after alpha-adrenergic blockade. Pressure transducers were implanted into the left ventricle of cats who had been trained operantly to perform static exercise. Significant increases in LVSP, LV(dP/dt)max and HR occurred in all cats during static exercise before blockade. In contrast, alpha-adrenergic blockade (phentolamine, 2.5 mg/kg iv) abolished the exercise-induced increase in LVSP but did not prevent increases in HR and LV(dP/dt)max. The cats performed fewer exercise bouts per day during alpha-blockade than when unblocked. We conclude that an alpha-adrenergic mechanism mediates the increase in LVSP in response to static exercise in conscious cats.

Adrenergic alpha-Agonists↗
PubMed1981

[Morphological studies into pulmonary arterioles in pregnant rabbits with experimental hypertension (author's transl)].

Arterial hypertension was evoked in pregnant rabbits by daily applications of 2.5 microgram/kg/min of CIBA hypertensin, beginning on the 16th day of pregnancy. The animals were sacrificed on the 30th day of pregnancy. Pathological changes were histological recorded from their pulmonary arterioles, particularly those between 100 and 400 micron in outer diameter. They were vascular contraction, hyperplasia of exterior and central vascular layers, oedema, elastosis as well as fibrinous and hyaline proliferation. Non-pregnant rabbits, which had received the same dose of hypertensin, died on the third day from application. Their pulmonary arterioles were found to have undergone contraction. No vascular changes were recordable from clinically intact pregnant rabbits.

Animals↗
PubMed1981

[Intra-uterine foetal development and behaviour of circulating blood in pregnant rabbits with experimental hypertension (author's transl)].

The isotope method with labelled albumin 131J was applied to pregnant rabbits with pharmacologically induced hypertension to study both the volume of circulating blood and intra-uterine development of the foetus. The volume of circulating blood as well as birth-weight and head-breech length of the foetus were all reduced with statistically secured significance in the experimental group by comparison with a control group.

Animals↗
PubMed1980

[Comparative studies into lipid component levels of parturients with EPH gestosis and of their newborns (author's transl)].

Statistically significant rises in LDL (low density lipoprotein) concentrations, low cholesterol levels, and total lipid levels significantly below those recorded from newborns of clinically intact mothers were established from newborns of mothers with moderate and severe EPH gestosis. The above parameters did not deviate largely from the normal in patients with moderate gestosis. The levels of total lipids, cholesterol, and LDL in the serum of the newborns were clearly lower than those recordable from the serum of the mothers.

Cholesterol↗