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M Bogusz

Publications and source records attributed to M Bogusz.

At least 37 records · Page 2Linked to original sources
PubMed1984

Potentials of capillary gas chromatography in toxicology today.

The usefulness, the applicability and the limitations of capillary gas chromatography in various types of toxicological analysis were discussed. Technical parameters of capillary gas chromatography, such as type of injector, type of column with regard to material, size, and stationary phase were assessed in view of the requirements of toxicological analysis. The main advantage of capillary gas chromatography, i.e. high separation power, is unfortunately counterbalanced by low loadability and/or speed of analysis. In the present situation capillary gas chromatography is a method of choice in drug screening despite some disadvantages, but in drug-oriented analysis the conventional chromatography on packed; columns is probably more useful.

Chromatography, Gas↗
PubMed1981

Enzymic digestion of biosamples as a method of sample pretreatment before XAD-2 extraction.

Four proteolytic enzymes trypsin, protease type I, protease type V (Pronase AS) and protease type VIII (Subtilisin) were used for digestion of blood, brain, liver, and kidney in experimental poisonings of dogs with phenobarbital, amitriptyline, diazepam, and chlorpromazine. Enzymic digestion was used also in 21 forensic cases of fatal poisonings with hypnotic and psychotropic drugs. Each enzyme applied gave a similar yield. The efficienct of enzymic digestion varied according to the kind of drug, tissue, and individual. In general, enzymic hydrolysis proved useful in isolation of psychotropic drugs from liver and brain, being less effective in the case of blood. The mechanism of drugs liberation after enzymic treatment remains obscure.

Amitriptyline↗