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Biomedical subjects

M Borkenstein

Publications and source records attributed to M Borkenstein.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Hypoparathyroidism in hypomagnesemia].

Tetany was observed in a 18 months old girl, suffering from severe diarrhea. Even continuous iv calcium administration did not prevent tetanic spasms. Further evaluation revealed hypomagnesemia, hypocalcemia, and functional hypoparathyroidism. Administration of MgSO4 normalized serum levels of Mg and raised iPTH levels; tetany subsided. Serum calcium and P levels were normalized later. The pathogenesis of hypocalcemia secondary to magnesium deficiency might be a functional hypoparathyroidism as well as an endorgan-resistance to PTH.

Acute Disease↗
PubMed1981

[Urinary testosterone excretion in boys in relation to other parameters of somatic maturity (a longitudinal study) (author's transl)].

The dependence of urinary testosterone excretion on age was studied in healthy male volunteers. Furthermore, it was determined monthly over 2 years in 20 boys aged 10 to 12 years. The values obtained for urinary testosterone were compared with the parameters of somatic growth like bone age, height, weight and testicular volume. The greatest intraindividual changes in testosterone excretion were found during puberty, and also a great interindividual difference in the onset of puberty. A relatively good correlation was obtained for the mean testosterone excretion and the bone age, on the one hand, and the testicular volume of a boy on the other hand.

Adolescent↗
PubMed1981

[Cytomegalovirus in subacute infant pneumonitis (author's transl)].

A subacute pneumonic disease of a young infant is described. Insidious onset, afebrile course, tachypnea, staccato cough, disseminated crepitations on auscultation, signs of infiltration and hyperexpansion on chest X-ray, eosinophilia as well as elevation of immunoglobulin fractions G and M suggested infection with chlamydia trachomatis. Microbiologic investigations, however, documented active infection with cytomegalovirus. Hence these symptoms were either caused by both organisms or constitute a rare monorganic manifestation of connatal cytomegalovirus disease. The syndrome of subacute pneumonia in the young infant might not necessarily depend on the infection with a specific organism.

Cytomegalovirus Infections↗
PubMed1980

Haemostatic changes in tall girls treated with high doses of ethinyloestradiol.

Haemostasis was studied in 8 tall girls during treatment with high doses of synthetic oestrogens for a period of 1 to 28 months. The girls received 0.5 mg ethinyloestradiol daily from day 1 to day 25 and 15 mg norethisteron daily from day 21 to day 25. All were without clinical signs of thromboembolism. Factors of the prothrobmin complex were significantly elevated in the tall girls compared to healthy controls of the same age. Fibrinogen was also significantly elevated. Factor VIII-related antigen was significantly higher in the tall girls and the ratio between factor VIII activity and factor VIII-related antigen was significantly decreased in the tall girls, as compared to the controls. Thrombin time was significantly shortened. Tests of primary haemostasis showed an increased tendency for thrombocytes to adhere to glass and to aggregate spontaneously and after stimulation with ADP or collagen. Whether these in vitro signs of hypercoagulability indicate an enhanced risk of throbmoembolic complications in tall girls treated with high doses of oestrogens remains to be established. However, these girls should be watched carefully for clinical signs of throbmoembolic complications during treatment.

Adolescent↗
PubMed1980

Pulmonary function studies in long-term survivors with artificial ventilation in the neonatal period.

Lung function tests in 11 children aged 2.5--5.5 years who required intermittent positive pressure ventilation (1--624 hrs) in infancy were obtained. The conditions necessitating artificial ventilation were hyaline membrane disease, neonatal apneic spells, aspiration of milk, and birth asphyxia. On examination the probands were in a good healthy state and without any subjective signs of dyspnea. Lung volumes could be measured in all of the probands. They did not show any statistically significant deviation from standards for height and correlated with the age of the probands. Time related flow rates were sufficiently measurable in 7 probands only, who cooperated adequately. In 6 of them the expiratory flow showed a decrease of the effort independent portion with a slight increase in the total airway resistance. There was no correlation between the condition requiring artificial ventilation, the former therapeutic characteristics and the degree of the pathological lung function tests. The results of this investigation suggest damage of the smallest airways which could be the reason for the obstructively impaired expiratory patterns seen in 6 of the probands.

Asphyxia Neonatorum↗
PubMed1980

[Normal values for circulating thyroid hormones, T3 uptake and thyrotropin before and after TRH. Radioimmunoassay determinations on 182 euthyroid children (author's transl)].

Measurements of T4, T3, rT3, T3U, and TSH (before and after TRH stimulation) were performed by RIA. 182 children, apparently euthyroid, age 2/12--14 years, were investigated in a cross sectional study. Free T4RIA and free T3RIA Indices and the ratio rT3/T3 and T4/T3 were calculated. Statistical analysis showed the following results: 1. Geometric mean serum concentrations of T4, T3, rT3 and TSH (basal) show no age related differences; T4 showed a not significant negative slope with age.--2. The ratio rT3/T3 and T4/T3 remains constant.--3. TRH induced TSH release (indicating the activity of the regulatory system) is unchanged from 2/12 to 14 years. Geometric means values, standard deviations and normal ranges are given.

Adolescent↗
PubMed1980

[Value of routine skull radiography for etiology of simple febrile seizures (author's transl)].

The dramatic episode of a febrile seizure, happening short and generalized with normal children, has a good prognosis. The examiner has to perform a very exact differential diagnosis in which an exact history and physical examination have to be on the first place, followed by serological examinations, the EEG and occasionally a lumbar punction. Skull radiography, as we wanted to show in the paper, has lost its place in general examination and should be reserved for special cases.

Child, Preschool↗
PubMed1979

[Bone scan of acute hematogenous osteomyelitis in childhood (author's transl)].

A variety of 99m-Tc-phosphate compounds are sensitive and reliable for scintigraphic diagnosis of bone diseases. Therefore bone scan has become a safe method for evaluating patients with suspected acute hematogenous osteomyelitis. So we were able to perform early and adequate treatment without evidence of bony changes in the radiograph. Quantitative regional measurements with a relative uptake ratio was found to be a clinically useful parameter in the follow-up of osteomyelitis.

Acute Disease↗