Treatment of ingestion of diphenhydramine.
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Diphenhydramine↗
Biomedical subjects
M Borkenstein
Publications and source records attributed to M Borkenstein.
["Late onset disease" (congenital german measles) (author's transl)].
The paper reports on a case of "late onset disease" (congenital German measles). Diagnostically significant for this disease in an infant appearing perfectly healthy when new-born, were mainly the findings of an interstitial pneumonia, hepatosplenomegaly, as well as findings indicating the presence of a meningoencephalitis and retinopathy. The diagnosis of this rare course of congenital German measles was finally established via the identification of specific IgM rubeola antibodies, of a raised hemagglutination inhibition titer, and of the German measles virus itself. An attempt to treat the interstitial pneumonia with cortisone preparations remained unsuccessful. The clinical and diagnostic problem complexes are discussed briefly.
Antibodies, Viral↗
[Silver-Russell syndrome with panhypopituitarism (author's transl)].
This is a report on a 14 years old boy suffering from the unusual combination of Silver-Russell syndrome with panhypopituitarism. The Silver-Russell syndrome is a special form of primordial dwarfism characterised by congenital asymmetry, craniofacial dysmorphy and other anomalies. Its cause is unknown, intrauterine noxes and genetical factors are discussed. In the most cases results of hormone determinations are normal, but also cases with elevated or very low hormone levels were published. This is the first report about a Silver-Russell syndrome combined with panhypopituitarism.
Abnormalities, Multiple↗
[Determination of faecal fat in infants and children with bacterial and viral infections (author's transl)].
In 100 infants and children with bacterial or viral infections determination of faecal fat was done. None of the patients showed signs of malabsorption prior to investigation. The faecal fat content is expressed as percent of the dry weight of the stool. A fat content of up to 14% of the dry weight of the stool can be regared as normal. A faecal fat content of 15 to 20% is indicative for an elevated fat excretion, and a fat content of more than 20% gives evidence for steatorrhoea. In 80% of the infants with bacterial and in 50% of the infants with viral infections steatorrhoea could be demonstrated. In children with bacterial infections 18% showed a normal, 69% an elevated fat excretion ain 13% there was a steatorrhoea. In children with viral infections 6% showed a normal fat excretion whereas 81% had an elevated excretion and 13% exhibited steatorrhoea. Thus viral infections compared with bacterial infections seem to cause disturbances of fat absorption more frequent. Whereas the degree of the disturbance seems ot be less intense in viral infections.
Bacterial Infections↗
[Dimenhydrinate poisoning in childhood (author's transl)].
Treatment of a Dimenhydrinate poisoning (Vertirosan B6) with Physostigmine salicylate (Antrilirium) is reported. The symptoms of this anticholinergic poisoning (hyperactivity, ataxia, tremor, rubeosis faciei, hallucinations) disappeared rapidly after a single intravenous injection of Physostigmine salicylate. A table of some of the most common drugs capable of producing anticholinergic poisoning is added.
Ataxia↗
How to collect blood for the measurement of HGH, LH, FSH, cyclic AMP, folic acid, cortisol and testosterone.
In order to estimate peptide hormones, steroid hormones, folic acid and cyclic AMP in the same blood sample we investigated the influences of different anticoagulants on the measurement. It could be demonstrated that blood collected in EDTA-coated tubes can be for the measurement of each of the mentioned constituents.
Anticoagulants↗
Treatment of cryptorchidism by intranasal synthetic luteinising-hormone releasing hormone. Results of a collaborative double-blind study.
The effect of intranasal luteinising-hormone releasing hormone (L.H.R.H.) in 84 boys with unilateral or bilateral cryptorchidism was evaluated in a double-blind controlled trial. Boys with retractile testes were not studied. L.H.R.H. caused no side-effects; plasma antibodies to L.H.R.H. were never demonstrated. Four weeks' therapy with intranasal L.H.R.H. administered in six doses daily (1.2 mg/day) led to complete descent in 38% of a total of 61 testes, an improved position in 28%, and no response in 19%; 15% of testes were never palpated. After placebo the position of 25% of testes was improved; there was no response in 75% of a total of 51 testes. The success-rate seemed to be independent of age, but was related to the initial testicular position, with complete descent in only 11% of testes not previously palpated compared with 48% of testes found in the inguinal region.
Administration, Intranasal↗
[Diagnosis of congenital cytomegaly].
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Cytomegalovirus Infections↗
Prenatal diagnosis of campomelic dysplasia by ultrasonography.
Consanguineous partners had a boy with campomelic dysplasia who died of increasing respiratory distress soon after birth. The next pregnancy was monitored frequently by ultrasonography and a healthy male infant was born at term. During a further pregnancy, ultrasonography suggested campomelic dysplasia in the 16th week of gestation. This was confirmed in the 18th week. The pregnancy was terminated and the fetus showed the typical radiological, anatomical and histological findings.
Bone and Bones↗
[Congenital hyperthyroidism caused by diaplacental exchange of thyrotropin receptor antibodies].
We describe the case of a premature baby, extremely small for date whose mother had an untreated hyperthyroidism during pregnancy. Severe symptoms of connatal hyperthyroidism appeared after a latency period of seven days. As the underlying cause we suggest the placental transmission of thyrotropin-receptor-antibodies (TRAb), which were elevated in the mother and the newborn. Main symptoms in the newborn were tachycardia, tachypnea, sweating and diarrhea.
Autoantibodies↗
Screening of patients with Turner syndrome for "hidden" Y-mosaicism.
The presence of Y-chromosomal sequences in the cells of patients with Turner-Syndrome (TS) is a risk factor for the development of gonadal tumors. Therefore and since demonstration of Y-material usually results in prophylactic gonadectomy optimal sensitivity and specificity of the diagnosis have to be attempted. We wanted to evaluate the diagnostic potential of cytogenetic investigations as routinely employed in TS. In the most comprehensive study published so far we screened 208 TS patients for the presence of Y-chromosomal sequences by polymerase chain reaction (PCR) specific for eight different loci along the Y-chromosome. Six patients (3%) without cytogenetic evidence of Y-chromosome were found to be Y-positive. Among 12 cases with marker chromosomes two more Y-chromosomal fragments were identified. Thus, PCR-screening for Y-specific sequences was shown to be a valuable tool in the clinical management of Turner patients.
Adolescent↗
Immunogenicity of human insulin (Novo) or pork monocomponent insulin in HLA-DR-typed insulin-dependent diabetic individuals.
The immunogenicity of human insulin (Novo, Monotard, Actrapid) or pork monocomponent (MC) insulin (Monotard, Actrapid) was studied in 102 HLA-DR-typed patients with newly diagnosed insulin-dependent diabetes mellitus (type I diabetes). After 6 mo of treatment, IgG-insulin antibodies were found in only 14% of the patients receiving homologous MC insulins, but in 29% of the patients on heterologous MC insulins. IgG-insulin antibody titers were significantly lower in patients treated with human insulin compared with diabetic patients who received the corresponding pork MC insulin preparations from the onset of their disease. The previously reported strong influence of immunogenetic factors in determining the magnitude of the anti-insulin immune response was supported by the findings obtained in the pork MC insulin-treated diabetic individuals. Incidence of circulating immune complexes was 14% and 5% after 3 and 6 mo, respectively, of treatment with human insulin, which is considerably lower than previously reported in patients using heterologous non-monocomponent insulin preparations.
Adolescent↗
Severe hypoglycemia in children and adolescents with IDDM: frequency and associated factors.
Severe hypoglycemia is a very common complication in youths with insulin-dependent diabetes mellitus (IDDM). Seventy four children and adolescents were surveyed for a 1-year period to evaluate the frequency and associated factors of severe hypoglycemia. Patients or their parents completed a standardized questionnaire which inquired about severe and mild episodes, treatment, and prevention of hypoglycemia. Forty-four percent of the patients experienced at least one severe hypoglycemic episode [need for assistance (grade III), loss of consciousness with or without convulsions (grade IV)] during the survey period. The event rate was 0.77 episodes (grade III and IV) per patient-year. The group with severe hypoglycemic episodes was significantly older (mean age, 16.3 years; SD, 3.6 years versus mean age 13.7 years; SD, 4.9 years; p = 0.01) and had significantly longer duration of diabetes (mean, 8.2 years; SD, 4.3 years versus mean, 6.1 years; SD, 4.0 years; p = 0.04) than the group without severe hypoglycemic episodes. There were no significant differences in mean glycosylated hemoglobin (HbA1c), daily doses of insulin, type of insulin regimen, gender, and age at diagnosis between patients who reported severe episodes and those who did not. Mild hypoglycemia was reported by 72 patients. Fifty percent of the patients recognized potential precipitating factors. Older age and longer duration of diabetes seem to predispose the patient to severe hypoglycemia. This may be the result of a diminution of the counterregulation system including lower neuroadrenergic reaction, or the still unphysiologic treatment of diabetes. Continued vigilance and education is important in older adolescents with longer duration of diabetes.
Adolescent↗