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Biomedical subjects

M Chatani

Publications and source records attributed to M Chatani.

At least 55 records · Page 3Linked to original sources
PubMed1989

[A multiinstitutional prospective randomized study of radiation therapy of bone metastasis. II. Prognostic factors].

A prospective randomized study for the analysis of optimal schedule for the patients with bone metastases was performed. From February 1986 through January 1987, a total of 131 patients entered on this trial. The data from 129 patients out of 131 were available for the analysis of prognostic factors by Cox's regression model. As a whole, it was clear that first significant prognostic factor was urinary hydroxyproline/creatinine ratio (p = 0.0001), second primary site (p = 0.0001), third pain score (p = 0.0005) and fourth other organ metastasis except bone (p = 0.0006). In the group of lung cancer, first significant prognostic factor was urinary hydroxyproline/creatinine ratio (p = 0.0007), second multiplicity of bone metastasis (p = 0.0113), and third pain score (p = 0.0270).

Bone Neoplasms↗
PubMed1989

Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region.

A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic resection, without operative death. Histologically, in 13 of these 16 cases, the population of severely degenerative cancer cells (SDCC) was more than 1/3 of all cancer cells, and SDCCs were likely to locate at the periphery (advancing point of carcinoma). These histological patterns were considered as favorable to improve the operative curability. However, in the remaining three cases, the SDCC population was less than 1/3. In addition, nonaffected (i.e., viable) cancer cells were detected at the periphery, and this is an extremely adverse condition for subsequent surgery. Chronic pancreatitis in the noncancerous area was present in these three cases, but not in the 13 cases. Therefore, the most significant factor that predicts the radioresistance especially at the periphery of the carcinoma was considered to be coexisting chronic pancreatitis.

Adenocarcinoma↗
PubMed1989

Radiation therapy for early glottic cancer (T1N0M0): I. Results of conventional open field technique.

From November 1977 through April 1982, a total of 91 patients with glottic cancer (T1N0M0) were treated with the open field technique of 4 MV X ray using bilateral parallel-opposed fields. Total radiation dose administered was 60 Gy in 30 fractions over a 6-week period. Actuarial 5-year disease-free survival rate was 89%. Significant prognostic factors of local control were tumor length (p = 0.021), tumor width (p = 0.001), tumor type (p = 0.004), tumor response to irradiation at 40 Gy (p = 0.000) and 60 Gy (p = 0.000) by chi-square test. Ultimate local control rate by radiation therapy and salvage surgery was 97% and voice preservation rate was 91%.

Adult↗
PubMed1989

Rearranged Epstein-Barr virus genomes and clonal origin in nasopharyngeal carcinoma.

Epstein-Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NPC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single-sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV-infected cell.

Antibodies, Viral↗
PubMed1989

Molecular cloning and physical mapping of the DNA of Miscanthus streak geminivirus.

Molecular cloning and physical mapping of miscanthus streak virus (MiSV) circular double-stranded (ds) DNA was carried out. The circular dsDNA was isolated from leaves of Miscanthus saccariflorus (Gramineae) infected with MiSV. In addition to the monomeric circular dsDNA form in MiSV-infected leaves, there were minor circular dsDNA populations of twice (dimer) and approximately half genome length. The size of monomeric circular dsDNA was about 2.67 kilobase pairs. The evidence presented suggests that the genome of MiSV consists of one component.

Cloning, Molecular↗
PubMed1989

[Local control after radiation therapy for T1N0M0 glottic carcinoma].

From 1978 through 1984, we had 151 patients with T1N0M0 glottic carcinoma. They were treated by radiotherapy with 4MV x-ray in parallel opposing field of 5 X 5 cm2 or 6 X 6 cm2. The total dose was 60 Gy/30 fractions/6 weeks. The local control rate was 88.1%, the local recurrence being noted in 18 cases (11.9%). Of these 18 cases, 6 underwent partial laryngectomy, and 10 total laryngectomy. The remaining two cases died: one refused further treatment for recurrence and the other died in spite of total laryngectomy due to recurrence after partial laryngectomy. The salvage rate was 94.1%. The cumulative survival rate was 82.6% in Tla, 71.5% in Tlb and 81.1% in 151 T1N0. The tumor response was poor in the presence of lesion occupying the whole length of the vocal cord. Also, in the cases with ulcer formation or thickened vocal cord as seen on laryngogram, local control rate was not good. Better results will be achieved by improving treatment techniques, specially by improving dose-distribution by wedge-filtered technique and method for immobilization in plastic shell during radio-therapy.

Adult↗
PubMed1989

[Prognostic factors in patients with brain metastases from lung carcinoma].

Between September 1980 to December 1984, 85 patients with brain metastases from lung carcinoma were consecutively evaluated and were entered into the first prospective randomized trial. Since January 1985, the second prospective randomized trial was started based on the result of the first trial, i.e., lactate dehydrogenase (LDH) as the most important prognostic factor. We analyzed neurological improvement and survival of 79 patients, who were entered into the second trial until November 1988, compared with the first trial. This preliminary result suggests that LDH may also be an important prognostic factor in the second trial.

Brain Neoplasms↗
PubMed1989

[Radiation therapy with or without cisplatin in esophageal carcinoma].

Of 74 patients with an esophageal carcinoma, 26 were treated with a combined modality of radiotherapy and cisplatin (CDDP group), and 48 were treated with radiotherapy alone (RT group). Sixteen patients were salvaged by surgery after radiotherapy. Fifty-two patients were found to have a loco-regional disease (RT group: 34 patients; CDDP group: 18 patients) and 22 patients had a distant metastasis at the time of the initial treatment (RT group: 14 patients; CDDP group; 8 patients). For those with a loco-regional disease, the response rate was for those in the CDDP group and 34% for those in the RT group. For non-surgically salvaged cases, the median survival was 12 months and there was no statistically significant difference between the CDDP and the RT groups. For the surgically salvaged cases, 2 out of 7 patients in the RT group and 5 out of 9 patients an in the CDDP group are still alive. Additionally, four T3 cases were salvaged by surgery in the CDDP group.

Aged↗
PubMed1989

[Radiation therapy of early glottic cancer (T1N0M0); retrospective review of historical control].

From November 1977 through April 1982, a total of 91 patients with early glottic cancer (T1N0M0) were treated with the open field technique of 4 MV X-ray using parallel opposed fields in bandage. Radiation dose administered was 60 Gy in 30 fractions over 6-week periods. Actuarial 5-year disease-free survival rate was 88.7%. Significant prognostic factors of local control were tumor length, tumor width, tumor type, tumor response at 40 Gy and 60 Gy. Ultimate local control rate by salvage surgery was 97% and voice preservation rate was 91%.

Actuarial Analysis↗
PubMed1989

[Cis-diamminedichloroplatinum (CDDP)-radiation therapy of an advanced nasopharyngeal carcinoma].

Between November 1983 and May 1985, 11 patients with locally advanced (stage IV) nasopharyngeal carcinoma were treated using a combination of Cis-diamminedichloroplatinum and radiation therapy (CDDP-RT group). In this group, 7 patients were given radical RT, sandwiched between 1 course of CDDP (70 mg/m2) before and 1 after. Four patients were given 1 course of CDDP prior to RT. Treatment results were compared with 32 patients (stage IV) who were treated with radiation therapy alone (RT group). These groups showed almost the same local control rate and distant relapses. There was no significant difference in the actuarial and relapse-free survival between the CDDP-RT group and the RT group. As a side effect, severe mucositis of the oral cavity was observed in 4 patients (36%) of the CDDP-RT group in contrast with 3 patients (9%) of the RT group (p less than 0.05).

Adolescent↗
PubMed1988

High-dose rate intracavitary therapy for carcinoma of the uterine cervix: II. Risk factors for rectal complication.

From August 1978 through December 1982, a total of 267 patients with carcinoma of the uterine cervix were treated using remote afterloading high-dose rate intracavitary therapy (RALS) with non-rigid applicator at our department. The data from 199 previously untreated patients with standard application out of 267 were available for this analysis of rectal complication. The incidence of moderate to severe rectal complication (Kottmeier's grade 2 and 3) was 7% (13/199). Cox's regression model was used for the analysis of risk factors for rectal complication in which even minor injuries (grade 1) were included. By using this method, it was clear that the first significant risk factor was z-coordinates of weighted geometric center (WGC-z) (p = 0.0007) and the second corresponding factor was rectal TDF (p = 0.0082), the sum of the rectal dose measured by semiconductor dosimeter (ICD-5) and the dose of external whole pelvic irradiation. From the analysis of application pattern of intracavitary sources, WGC-z indicated the approximation of intracavitary sources to the anterior wall of rectum quantitatively and three-dimensionally. The significance of rectal TDF also implied that the monitoring of rectal dose by ICD-5 had an important role for the prediction and prevention of rectal complication after RALS.

Analysis of Variance↗
PubMed1988

Radiation therapy for carcinoma of the hypopharynx with special reference to nodal control.

From October 1977 through December 1983, 61 patients with carcinoma of the hypopharynx were treated with radiation therapy (RT) and surgery or with RT alone. Five-year survival rates by N-stage, according to the TNM classification by UICC (1978), were 52% for N0 cases, 23% for N1, and 17% for N2-3 (N1 vs. N2-3, not significant). For N1-3 cases, corresponding figures by level of cervical nodal involvement by UICC (1978) were 29% for level 3 cases, 15% for level 2, and 8% for level 4 (level 3 vs. level 4, p less than 0.04). Therefore, the level of cervical nodal involvement was a more useful prognosticator for patients with nodal metastasis than the N-stage. Effective nodal control for patients with clinically positive nodes (N1-3) was obtained with a combination of neck node dissection and RT of 50 Gy or more. For N0 cases, elective RT of 50 Gy or more, encompassing an adequate field, was required.

Adult↗
PubMed1988

Radiation therapy combined with or without chemotherapy for limited extent of non-small cell lung carcinoma.

From July 1977 to December 1983, 130 patients with limited extent of non-small cell lung carcinoma received radiotherapy of more then 30 Gy combined with or without chemotherapy at the Center for Adult Diseases, Osaka, Japan. Four treatment arms were evaluated: RT alone, RT following chemotherapy, RT following low dose concurrent irradiation with chemotherapy (LDC-RT), and RT concurrently used with chemotherapy. Complete regression of local and regional tumor was produced in 5% and partial regression 58%. Among these four treatment arms LDC-RT showed the highest response rate (88%), while no difference in long-term survival was apparent. According to the RT dose, survival of cases who received RT doses above 50 Gy was better than that of cases under 50 Gy in spite of the combination with chemotherapy. These data suggest that adjuvant chemotherapy has no favorable impact against the survival. Concerning the prognostic factor, tumor response after treatment, general performance status and N stage were important.

Antineoplastic Combined Chemotherapy Protocols↗