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Biomedical subjects

M Chomarat

Publications and source records attributed to M Chomarat.

At least 37 records · Page 2Linked to original sources
PubMed1991

Susceptibility to aminoglycosides of 63 strains of Stomatococcus mucilaginosus isolated from sputum.

The MIC of 63 Stomatococcus mucilaginosus for 7 aminoglycosides was determined. Most of the strains were resistant to these antibiotics except to streptomycin. A natural resistance due to impermeability may be involved. One single strain was resistant to all these aminoglycosides where the concentration level of streptomycin was greater than 1000 mg/l. A chromosomal mutation is probably involved.

Aminoglycosides↗
PubMed1991

Coagulase-negative staphylococci emerging during teicoplanin therapy and problems in the determination of their sensitivity.

Four strains of coagulase-negative Staphylococcus spp. were isolated from blood cultures taken from two neutropenic patients; in three cases while they were receiving teicoplanin as part of an antimicrobial therapeutic regimen. Results of teicoplanin susceptibility tests carried out on these strains varied according to the technique used. The strains were susceptible by disc-diffusion testing, but the MIC of teicoplanin was 8-16 mg/l, when tested according to the recommendations of the Antibiogram Committee of the French Society of Microbiology, and thus categorized as of intermediate susceptibility. It seems reasonable to avoid using teicoplanin for the treatment of infections caused by coagulase-negative staphylococci until technical problems encountered in the in-vitro determination of susceptibility have been resolved.

Adult↗
PubMed1991

[Treatment of acute otitis media: comparative study of efficacy of cefatrizine and amoxicillin-clavulanic acid].

Fourty hospitalized patients (15 children, 25 adults) suffering from acute otitis media have been treated with either cefatrizine or amoxycillin-clavulanic acid. Bacteriological samples were done during surgery by tympanocentesis (N = 33) or by sampling of middle ear fluid specimens (13). H. influenzae was the most common isolate, following by Enterobacteriaceae, S. aureus, P. aeruginosa, and S. pneumoniae. We conclude that these two antibiotics can be used for treatment of acute otitis media in our country even in adults where the order of frequency of bacteria is different from those reported in children.

Acute Disease↗
PubMed1991

[Randomized study of amoxicillin-clavulanic acid versus amoxicillin-metronidazole combinations in pyogenic infections of dental origin].

Thirty patients, without any valve defect, cardiac malformation or previous antibiotic administration and presenting dental infections, have been treated either with amoxycillin-clavulanic acid or amoxycillin and metronidazole. Aerobic and anaerobic bacteria have been isolated. These infections were due to mixed flora. Nearly one half of anaerobes were Peptostreptococcus, S. milleri and S. sanguis being predominant among aerobes. The species identified were those found in the mouth in the absence of infection becoming as opportunistic flora. The percentage of cures was equivalent in the two groups. the association amoxycillin-clavulanic acid seems to be as active as amoxycillin + metronidazole on the microflora isolated from dentogenous pyogenic infections.

Adolescent↗
PubMed1990

Two cases of severe infection with beta-haemolytic group A streptococci associated with a toxic-shock-like syndrome.

Two cases of severe infection due to Streptococcus pyogenes associated with a toxic-shock-like syndrome (TSLS) and also with serious soft-tissue infection are described. Serotyping and detection of A, B and C exotoxins were carried out on strains isolated from blood cultures and skin samples. The strain of serotype M1 T1, which produced 10 ng/ml of exotoxin A and also synthesised exotoxins B and C, caused severe TSLS associated with major skin lesions. The second strain of serotype M12 T12, which produced only 1 ng/ml of exotoxin A and synthesised exotoxin B, was associated with clinical manifestations of adult respiratory distress syndrome. The relationship between the magnitude of exotoxin production and the severity of clinical manifestations cannot be established from these two cases.

Adult↗
PubMed1990

[The use of teicoplanin in neutropenic patients: values and limits].

The efficacy and the safety of teicoplanin were evaluated for the treatment of febrile episodes in neutropenic patients. A total of 18 patients received teicoplanin once daily as an intravenous injection of 200 mg in 6 patients (after a loading dose of 400 mg) or 400 mg in 12 patients (loading dose: 800 mg). The mean duration of therapy was 15.9 days (range 9 to 39 days). In all patients teicoplanin was combined with another antibiotic usually a beta-lactam. Thirteen of 18 patients were successfully treated. Three febrile episodes proved to be microbiologically documented infections and were cured by teicoplanin: one Streptococcus mitis and two methicillin-resistant (methi-R) Staphylococcus epidermidis bacteremias. Neither toxicity nor side effects were observed in the reported group. Six patients experiencing reactions to vancomycin (2 cases of cutaneous allergy) or to vancomycin and amphotericin B combination (4 cases of nephrotoxicity) were subsequently treated with teicoplanin without any evidence of cross-sensitivity. We observed emergence of teicoplanin-resistant coagulase-negative Staphylococcus in 3 patients receiving teicoplanin: 20, 18 and 8 days after a first febrile episode cured by teicoplanin and a beta-lactam, they developed fever while receiving the same antibiotic regimen. Methi-R Staphylococcus epidermidis was isolated from blood cultures in the first patient and methi-R Staphylococcus haemolyticus in the two other patients. In one patient, successfully treated by teicoplanin for a first febrile episode related to a methi-R Staphylococcus epidermidis, emergence of Staphylococcus haemolyticus occurred 8 days later while the patient was on teicoplanin therapy (6 mg/kg). MICs of teicoplanin were 16 mg/l for the two Staphylococcus strains isolated in this patient.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Protection of mice by a pseudodiffuse strain of Staphylococcus aureus possessing polyvalent capsular type antigen.

Staphylococcus aureus strain MC31 showed pseudodiffuse growth in serum-soft agar and reacted with immune rabbit sera to strains Smith diffuse (capsular type A), NS58D (type B) and NS41D (type C) but not with strain NS68D (type D) in serum-soft agar. Immunisation of mice with 300 micrograms of cell-surface polysaccharide extracted from strain MC31 protected against lethal infection by strain MC31 and the strains of capsular types A, B and C. Immune rabbit serum prepared against strain MC31 passively protected mice against challenge infection with the homologous strain, but approximately 30 times more anti-MC31 serum was required to protect against infection with the strains of capsular types A, B and C. Absorption of the passive protective activity of immune sera raised against the three capsular type strains required at least 10 times the quantity of MC31 cell-surface polysaccharide than the quantity of cell-surface polysaccharide from the homologous capsular strain. Electronmicrographs of strain MC31 treated with ferritin-labelled antisera to the three capsular strains showed only small amounts of ferritin granules around the cell wall.

Animals↗
PubMed1989

[Antibiotic sensitivity of 32 strains of Stomatococcus mucilaginosus in oral medicine patients in community practice].

Susceptibility to eleven antibiotics of 32 strains of Stomatococcus mucilaginosus isolated from gingival or dental samples in patients who are nor hospitalized nor receiving antibiotics since six months was tested by diffusion and MIC. 12.5% of strains were resistant to macrolides and lincosamides. This result is significantly different from the result obtained with strains isolated from patients hospitalized for chronic pulmonary problems (36%). This resistance to antibiotics could be due to selection pressure as shown by the high incidence of resistant strains in antibiotic treated patients.

Dentistry↗
PubMed1988

Corynebacterium JK: surgical infections in non-immunosuppressed patients.

Infection caused by Corynebacterium JK (CJK) has been recently described in immunocompromised patients. To evaluate the frequency of CJK infection among surgical and trauma intensive care patients, all patients with CJK isolations at clinical sites were reviewed. The criteria used were the presence of bacterial infection symptoms, isolation from significant sites and the efficiency of a vancomycin treatment. Eight patients were studied; 3 of them were considered infected, while 5 were judged only colonized. It is concluded that CJK infections can be a clinical problem in surgical trauma patients.

Adult↗
PubMed1988

[Sensitivity to antibiotics of 64 strains of Stomatococcus mucilaginosus isolated in human clinical cases. Demonstration of erythromycin resistance].

Susceptibility to fifteen antibiotics of 64 stains of Stomatococcus mucilaginosus isolated from bronchial secretions was tested by susceptibility antibiotics diffusion and MIC method. Sixteen phenotypic profiles were determined by MIC. Some of these profiles and the spontaneous loss of resistance to erythromycin indicate plasmidic origin of this resistance.

Ampicillin Resistance↗