[Isolation of a strain of Middelburg virus from a batch of Aedes (A.) cumminsi gathered in Bandia (Senegal)].
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Biomedical subjects
Publications and source records attributed to M Cornet.
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Recent works carried out in west and central Africa resulted in numerous yellow fever virus isolations from sylvatic mosquitoes in the forest-savanna transitional zone. This virus was also obtained from monkeys, whereas studies on sequence and duration of the observed epizootics permitted a previsional approach of the yellow fever mechanisms in the same belt, the epidemiological importance of which was stressed ("emergence zone"). In the same course of research and publications, the prevalent part of the involved mosquitoes as virus-reservoirs was constantly emphasized ("reservoir-vector"). Recent investigations on transovarial transmission and yellow fever isolations from male mosquitoes caught in the field, provide decisive support to such a conception. It can explain that epizootics may be locally observed several years in succession, despite the fact that yellow fever virus circulation seems to be fundamentally of a dynamic character. Yellow fever virus was recently obtained from ticks and tick-eggs.
An epidemic of yellow fever raged during the last three months of 1983 in South East of Upper Volta. It spread on about ten thousand square kilometers, in a bushy savanna area, affecting only populations living in contact with forest galleries, belonging especially to the peul ethnical group. The transmission of the virus was effected by sylvatic vectors, essentially Aedes furcifer. Serological tests showed that about 50 % of the population living in contact with forest galleries was affected, that is to say 15.000 to 17.500 people. The average death rate on the whole area was 4 % (800 to 1.700 deaths); the lethality rate was estimated between 6 and 10 % of affected people. On the whole, 54 strains of yellow fever virus were isolated from human blood samples, and 26 strains from batches of mosquitoes. We called this epidemic "intermediate sylvatic epidemic". The epidemic quickly decreased in the sylvatic area, owing to climatic conditions. A mass campaign of vaccinations prevented it from spreading to near urban centres. On this particular case, the thermostability on field of the vaccine 17D provided by the Institute Pasteur of Dakar was proved to be effective.
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