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Biomedical subjects

M Cramers

Publications and source records attributed to M Cramers.

At least 19 recordsLinked to original sources
PubMed2001

Locobase repair cream following CO2 laser skin resurfacing reduces interstitial fluid oozing.

BACKGROUND: The cosmetic result after laser resurfacing depends not only on the type of laser and the technique used, but also on post-treatment care. The efficacy of Locobase Repair((R)) cream, which improves skin barrier function due to its content of natural skin analogue fats and cholesterol, was investigated. METHODS: A total of 18 Caucasian patients underwent resurfacing for acne scars. Laser treatment was performed with a Sharplan 1020 CO(2) laser and a Silk Touch scanner. Locobase Repair cream (a water-in-oil cream with 63% lipids including natural components of stratum corneum: cholesterol, ceramide and free fatty acids) was applied daily to one side of the face and petrolatum was applied to the other. In addition, both sides were treated with a 2% fusidic acid cream. RESULTS: There was a significant reduction of oozing during the first 2 days after CO(2) laser treatment on the sides treated with Locobase Repair cream (p < 0.05), CO(2) laser while from day 3 to day 7 no differences were demonstrated between the Locobase Repair cream and petrolatum. For the other parameters scored (scaling, oedema, erythema and pain), no significant differences between Locobase Repair cream and petrolatum were found. Furthermore, no significant differences were found between the two creams regarding the duration of wound healing and final cosmetic outcome. In all, 62% of the patients preferred to use Locobase Repair cream during the postoperative period, and 11% preferred petrolatum. The remaining 27% expressed no preferences. CONCLUSION: The use of Locobase Repair cream as a post laser resurfacing treatment reduces tissue fluid oozing during the first 2 postoperative days, indicating a quick restoration of skin barrier and hence possibly a reduction in the incidence of wound infections as well as enhancing patient compliance due to less fluid oozing.

Acne Vulgaris↗
PubMed2000

Hair reduction using a new intense pulsed light irradiator and a normal mode ruby laser.

OBJECTIVE: The main purpose of this clinical study was to compare the effectiveness of an intense pulsed light irradiator system (IPL) and a normal mode ruby laser for hair removal. MATERIALS AND METHODS: Thirty-one patients were treated 3 times with a new IPL system on one side of the chin and neck and with a normal mode ruby laser on the other side. After 6 months, nine of the patients received 3 additional IPL treatments and 11 patients received 3 additional ruby laser treatments. All treatment intervals were 2 months. Hair reduction was measured by hair counts on close-up photographs. RESULTS: Hair reduction was obtained by 93.5% of the patients after 3 IPL treatments and by 54.8% after 3 ruby laser treatments. The average hair count was reduced by 49.3% after IPL treatments and by 21.3% after ruby laser treatments. Three additional IPL treatments following 3 IPL treatments resulted in only 6.6% further hair reduction--in total 55.9%, whereas 3 IPL treatments following 3 ruby laser treatments resulted in an additional 35.5% hair reduction--in total 56.8%. CONCLUSIONS: The IPL was found to be 3.94 times more effective than the ruby laser for hair removal. In the chin and neck region, more than 3 treatments with the IPL did not improve the therapeutic result significantly.

Adult↗
PubMed1990

Twenty-nail dystrophy treated with topical PUVA.

A case of twenty-nail dystrophy treated with topical PUVA is described. The patient, a 19-year-old woman, had a 4-year history of a nail dystrophy involving all finger- and toe-nails. The finger-nail changes were treated with topical PUVA, dose 0.7-1.4 J/cm2 x 3/week. After 7 months excellent improvement was seen, while the untreated toe-nails were unaffected. A maintenance dose of 0.7 J/cm2 x 3/week was necessary to prevent recurrence. We suggest that topical PUVA is worth trying for the treatment of twenty-nail dystrophy.

Adult↗
PubMed1989

Wound dressing after skin planing.

A variety of dressings have been used following skin planing. Compresses are difficult to apply and simple bandages stick tight and are hard to remove. The Department of Dermatology has for several years used Collagen film, but this film is no longer commercially available. After 12 patients with acne scars underwent skin planing, synthetic polyurethanefilm (Omiderm) was applied for 7 days, with good results.

Acne Vulgaris↗
PubMed1988

Pivampicillin compared with erythromycin for treating women with genital Chlamydia trachomatis infection.

In a randomised single blind study, pivampicillin was compared with erythromycin in women with urogenital Chlamydia trachomatis infections. The pivampicillin dosage was 700 mg twice a day and the erythromycin dosage 500 mg twice a day for seven days. Follow up took place on days 7 and 14 after the start of treatment. All 26 women treated with pivampicillin were culture negative for chlamydiae at the first and second follow up visits. All 23 women who received erythromycin were culture negative at the first follow up visit, but one was culture positive at the second follow up visit. Gastrointestinal side effects were recorded in five patients receiving pivampicillin and in nine receiving erythromycin. Two patients receiving erythromycin were withdrawn from treatment because of gastrointestinal disturbances, compared with none receiving pivampicillin.

Adolescent↗
PubMed1988

Argon laser treatment of cutaneous vascular lesions in connective tissue diseases.

Two patients with juvenile dermatomyositis, 5 with chronic discoid lupus erythematosus, and one with Rothmund-Thomson's Syndrome were treated for their teleangiectasias of the face with argon laser. The results were highly satisfactory with an almost normal appearance of treated skin in 4 patients. Two patients showed satisfactory results with 60-70% blanching, while 2 patients showed some improvement, but not a completely cosmetically satisfactory result. The most impressive results were in the patients with juvenile dermatomyositis and Rothmund-Thomson's Syndrome. The only side effects observed were a slight scarring and an insignificant pigmentation. No patient displayed any signs of disease activation.

Adolescent↗
PubMed1985

Pivampicillin in treating genital infection with Chlamydia trachomatis.

Pivampicillin was used to treat urogenital colonisation with Chlamydia trachomatis in 41 women and 24 men who yielded chlamydiae but not gonococci. They were treated for 10 days. All but one patient gave negative chlamydia cultures 10 days after the start of treatment, and all 65 patients gave negative results at the second examination seven days later. Ten days of treatment with pivampicillin seems to be the optimum to eradicate C trachomatis from the lower genital tract in man.

Ampicillin↗
PubMed1985

Comparison of oxatomide and clemastine in the treatment of chronic urticaria. A double blind study.

A double-blind trial comparing a new antihistaminic agent (oxatomide) with clemastine was carried out in 30 patients with chronic urticaria. The study included over-all clinical assessment by patient and clinician as well as determination of excretion of 1,4-methylimidazoleacetic acid determined by a reversed-phase ion-pair high-performance liquid chromatographic method. It was found that the effect of oxatomide was equal to that of clemastine.

Adolescent↗
PubMed1983

Bestatin therapy of patients with atopic dermatitis.

Ten adult patients with severe atopic dermatitis were treated for three months with estatin, which is a metabolite of Streptomyces olivoreticuli. Bestatin has been shown to increase tumor resistance in mice, augment a variety of immune responses and to reduce the level of IgE in non-atopic healthy persons. During bestatin therapy we were not able to see any clinical change of the atopic dermatitis. No influence was found on the concentration of IgE in serum and the number of eosinophils in blood. The percentage of T lymphocytes and the Con A-induced suppressor cell activity was not changed. (Received June 18, 1983.)

Adjuvants, Immunologic↗
PubMed1982

The role of cadmium as a skin sensitizing agent in denture and non-denture wearers.

Positive patch test reactions to cadmium were observed in 8 out of 21 denture wearing persons with burning mouth sensations during 1979 and 1980, and in 13 of 125 consecutive outpatients being routine tested at the Dermatological Department in late 1980 and early 1981. Retesting 17 of these patients after at least 3 months delay with 2.0% cadmium chloride and 2% cadmium sulphate in water showed only 7 with a definite positive reaction. At serial dilution of cadmium sulphate, only 1 person reacted to a 1% aqueous solution. An exposure to cadmium could in 1 case be traced back to a 2-year period of work in a PVC plant, while in the remaining 6 cases the most probable exposure factor seemed to be chronic heavy cigarette smoking. The observations did not lend support to the pink acrylic denture base material being a relevant cadmium exposure factor.

Adult↗
PubMed1981

Skin reactions to a urea-containing cream.

Patch tests with a cream (Calmuril) containing 10% urea were performed on 79 patients with eczematous skin disease; seven (9.9%) had positive tests. Patch tests with the ingredients of the cream were negative. It is suggested that the positive patch test reactions are toxic, due to hypertonicity and acidity of the cream.

Adolescent↗
PubMed1981

Subpopulations of T lymphocytes and non-specific suppressor cell activity in patients with atopic dermatitis.

Thirty-five adult persons with moderate to severe atopic dermatitis and increased levels of IgE in serum were studied for the presence of Fc-IgG (T gamma) and Fc-IgM (T mu) receptor-carrying T lymphocytes in peripheral blood. When T lymphocytes from the patient were kept in vitro cultures a reduced expansion of the Fc-IgG receptors was found after 24 hr of incubation, but not after 48 hr of incubation. No difference was observed concerning Fc-IgM-carrying T lymphocytes. In 19 patients we studied Con A-induced suppressor activity of blood lymphocytes using autologous PHA-stimulated lymphocytes as target cells. Following stimulation with Con A, 1 microgram/ml, for 2 and 4 days, lymphocytes from atopic patients had a reduced non-specific suppressor activity in vitro. If however, the concentration of Con A was increased to 10 microgram/ml, then lymphocytes from atopic patients exhibited a normal suppressor activity.

Adolescent↗