Biomedical subjects
Publications and source records attributed to M Cramers.
A 27-year-old woman affected by porphyria variegata was treated with chloroquin for 1 1/2 years without any clinical improvement. Urinary excretion of porphyrins was not convincingly altered during treatment.
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In three patients a local dermatitis developed 3-3 1/2 months after tibial osteosynthesis with plates and screws of stainless steel 316 L (AO). Two of the patients had a positive patch test for chromium (and cobalt) and one for nickel. Infection was not indicated and it is suggested that the dermatitis was caused by a metallic sensitivity. The skin affection disappeared after removal of the metal.
The case is presented of a patient with busulfan (Myleran) treated myeloid leukaemia, who developed bullous pyoderma gangrenosum. Skin symptoms appeared at the time when treatment was discontinued due to signs of bone marrow depression. The pyoderma disappeared following treatment with systemic steroid.