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Biomedical subjects

M Cserhati

Publications and source records attributed to M Cserhati.

8 recordsLinked to original sources
PubMed1985

Clinical experience with preoperative chemotherapy for osteosarcoma.

Since 1978 preoperative chemotherapy has been administered to 15 consecutive patients with osteosarcomas in Zurich. Preoperative chemotherapy was acceptably well tolerated and did not impair surgical procedures. Our retrospective analysis confirmed that the extent of necrosis after preoperative chemotherapy is of biological importance for the further course of the disease. Patients with extensive necrosis had better relapse-free survival and longer overall survival than those with little necrosis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Effects of leukocyte interferon (E. coli) on human bone sarcoma growth in vitro and in the nude mouse.

Effects of highly purified human leukocyte interferon (rIFN-alpha 2) on colony formation, DNA synthesis and proliferation in nude mice of tumor cells from eight bone sarcomas have been studied. rIFN-alpha 2 produced a dose-dependent inhibition of [3H]thymidine incorporation by sarcoma cells. Even at high doses (10(4) U/ml), however, [3H]thymidine uptake could not be completely blocked by rIFN-alpha 2. In a cloning assay three established sarcoma cell lines and five other sarcoma samples obtained after short-term in vitro culture were found to be sensitive to various degrees to rIFN-alpha 2, complete inhibition being seen only at 10(4) U/ml. Three sarcomas were sensitive in the nude mouse model. Scheduling experiments revealed that rIFN-alpha 2 produces a delay in tumor growth only when administered either before or shortly after tumor implantation. Therefore rIFN-alpha 2 appears to be most active when tumor size is small and growth not exponential, indicating that rIFN-alpha 2 may play a role in an adjuvant setting. Growth sarcomas strongly suppressed by rIFN-alpha 2 in the cloning assay was markedly inhibited in the nude mouse. One sarcoma which was only moderately sensitive in the cloning assay was resistant in the animal experiment, confirming the predictive value of the clonogenic assay. Although the present findings demonstrate strong antitumor activity of rIFN-alpha 2 against human bone sarcoma cells they should be interpreted with caution mainly because the high rIFN-alpha 2 levels used in the experiments cannot be maintained in patients over a prolonged period.

Adolescent↗
PubMed1985

High-dose ifosfamide in advanced osteosarcoma.

In a prospective study, 18 evaluable patients with recurrent osteosarcoma were treated with ifosfamide, 1.8 g/m2 daily for 5 consecutive days. Courses were repeated every 4 weeks. Additional mesna (2-mercaptoethane sulfonate) was given to prevent urotoxicity. All patients had measurable lung deposits and all but one had been pretreated with various cytotoxic agents. Six patients (33%) showed therapeutic response, two complete and four partial, with a median duration of 5.5 months (range, 3-47+). Toxicity included myelosuppression, alopecia, nausea, and vomiting. No severe urotoxicity or central nervous system toxicity was observed. Thus, high-dose ifosfamide in combination with mesna seems to be a safe and effective agent for the chemotherapy of osteosarcoma.

Alopecia↗
PubMed1979

[Comments on the double-cup hip endoprosthesis according to Freeman (author's transl)].

Histological examinations (including tetracycline labelling) of preparations of the neck of the femur which had to be removed 1 1/2, 3 and 14 1/2 months subsequent to double-cup arthroplasty according to Freeman, prove that the bone tissue can remain vital under the solidly cemented metal cup. A thick layer of connective tissue with bundles of collagenous fibres running parallel to the surface, is temporarily formed between the cement layer and the prepared spongiosa of the neck of the femur. It is possible that this layer of connective tissue is replaced within about a years' time by a thin, lamellar cortex layer, which is then covered only by a thin layer of connective tissue which is rich in fibres. Below this layer, the spongiosa spaces are definitely widened and filled with fibrotic fat marrow; vascularisation decreases, whereas osteoporosis increases.

Adult↗
PubMed1978

[Chondrosarcoma. (An electronmicroscopic study) (author's transl)].

The ultrastructure of 6 chondrosarcomas was analysed. These areas which by means of light microscopy appear benign, displayed the same appearance as chondromas. Malignant areas are characterised by distined variation of cells, nuclei and nucleoli. There is an electron-dense zone of 400 A between the inner membrane of the nucleus and the chromatic in some nuclei containing dense chromatin. The amount of cytoplasmatic organellae decreases as differentiation decreases. Nevertheless there are sometimes cells with an unusual accumulation of cytoplasmic organellae.

Bone Neoplasms↗
PubMedDate not supplied

A case of congenital non-progressive sensory neuropathy with tonic pupils.

One case of a non-progressive congenital neuropathy is reported. Clinical findings included subtotal analgesia, and diminished temperature, vibration and proprioceptive sense in arms and legs. The sensory nerve action potentials were absent. Autonomic dysfunctions were restricted to tonic pupils. Sural nerve biopsy taken at the age of 8 1/2 showed fascicular hypoplasia, subtotal loss of myelinated nerve fibers and severe loss of unmyelinated nerve fibers with a pathological size distribution. In the skin biopsy, including several cutaneous nerves, no myelinated nerve fibers were present, the unmyelinated nerve fibers were severely reduced and the collagen density was increased. Perivascular and periglandular innervation was significantly reduced. The findings in this case are suggestive of a malformative or fetally acquired lesion and further illustrate the difficulties in classification of the hereditary sensory neuropathies.

Child↗