[Pharmacology and scientific and technical progress].
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Biomedical subjects
Publications and source records attributed to M D Mashkovskiĭ.
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In experiments on mice and rats quipazine exerts a moderate and short-term anorexigenic activity. N-acyl quipazine derivatives are markedly less toxic, do not exert anorexigenic action and influence weakly the serotoninergic and adrenergic systems.
Pharmacological properties of some typical and atypical antidepressants administered repeatedly are more alike as compared to their effects attained after a single administration.
On trabeculae of the frog's atrium it is shown by the method of the potential fixation with the use of a double saccharose bridge that novocainamide, quinidine and oxylidine mainly reduce the steady output membrane current and virtually have no effect on the input peak current. And, conversely, novocain significantly suppresses the input peak current and affects but little the steady membrane current.
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