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Biomedical subjects

M Dörr

Publications and source records attributed to M Dörr.

At least 19 recordsLinked to original sources
PubMed2006

Association between cardiac disorders and a decades-previous history of diphtheria.

A long, prior history of diphtheria is common among middle-aged and elder European adults. The aim of the present study was to determine whether the risk of reduced ventricular function and impaired intraventricular conduction is increased in individuals with a history of diphtheria. A study population of 2,480 subjects (1,222 women) aged 45 years or older who were recruited for the Study of Health in Pomerania were available for the present analyses. Left ventricular function was assessed by echocardiography. Intraventricular conduction blocks were diagnosed using electrocardiograms. Multivariable analyses revealed that individuals with a history of diphtheria had neither an increased odds for reduced fractional shortening (OR 1.21, 95% CI 0.69-2.11; p=0.51) nor an increased odds for intraventricular conduction blocks (OR 0.90, 95% CI 0.55-1.46; p=0.67). However, regression models revealed two-way interactions between the exposure variable and hypertension with respect to both endpoints. A history of diphtheria increased the odds for both endpoints in normotensive but not in hypertensive individuals. The findings show that a history of diphtheria several decades previously in a patient is a risk marker for reduced cardiac function and impaired intraventricular conduction in individuals at low risk for these disorders.

Adult↗
PubMed2005

Cardiovascular morbidity and mortality in thyroid dysfunction.

This review summarizes present knowledge from clinical and epidemiological studies with respect to cardiovascular complications in thyroid disorders, focusing on cardiovascular morbidity and mortality. Consistently, good evidence exists for an increased cardiovascular morbidity in overt hyperthyroidism, and an association with predictors of cardiovascular mortality like ventricular hypertrophy, ventricular dysfunction, and atrial fibrillation. As for subclinical hyperthyroidism evidence is conclusive only with respect to an up to 5.2-fold elevated risk for atrial fibrillation. The cardiovascular risk profile of overt hypothyroidism is characterized mainly by risk factors of atherosclerosis such as hypercholesterolemia and hypertension, but also by possible development of heart failure. In contrast, data on such parameters are inconsistent for subclinical hypothyroidism. Although many of these cardiovascular alterations may hypothetically worsen prognosis, results from cohort and retrospective studies do not consistently point towards increased mortality. Only for overt hyperthyroidism an up to 1.7 fold elevated risk for cardiovascular diseases and up to 1.7 fold increased cardiovascular mortality rates have been demonstrated. However, the evidence for similarly increased cardiovascular morbidity and mortality rates in subclinical hyperthyroidism and hypothyroidism is inconclusive, and the evidence is non-existent for overt hypothyroidism. Further randomized clinical studies and population-based cohort-studies are required and should consider major cardiovascular risk factors and adverse cardiovascular events and mortality.

Arrhythmias, Cardiac↗
PubMed2000

C-methyl-flavonoids from the leaf waxes of some Myrtaceae.

The thin waxy coatings on leaves of nine species of Callistemon, two of Melaleuca and one species of Metrosideros, have been studied for the occurrence of leaf surface flavonoids. The Callistemon species and Metrosideros robusta exhibit only C-methylated flavonoids, while O-methyl flavonoids were detected in Melaleuca huegelii. The new natural C-methyl flavonol, 5,7-dihydroxy-3,8,4'-trimethoxy-6-C-methylflavone, was isolated from Metrosideros robusta. The leaf wax of Callistemon coccineus contains the novel C-methylflavonoid, 5,4'-dihydroxy-8-C-methyl-7-methoxy flavanone.

Flavanones↗
PubMed1996

Representation of unique sequences in libraries of randomized nucleic acids.

From a library of nucleic acid molecules, which are randomized in parts of their sequence, unique sequence variants can be selected for specific properties. The planning of such an in vitro selection experiment requires some consideration regarding how much DNA template or RNA transcript should be used initially. The amount applied depends on the number of randomized nucleotides and on the expectations of how often each conceivable and unique sequence combination should be represented in the experimental pool. We display graphs describing the probability for the representation of unique nucleic acid molecules in a randomized pool as a function of the mean representation k, defined by the ratio of sampled nucleic acid molecules to conceivable sequence combinations and we summarize the amounts required to represent unique sequences with 99% likelihood. The probability of representation, P = 1-e-k, can be applied also to 'sub-saturated' pools (k < 1) of nucleic acids with long randomized domains, where it is impossible to provide sufficient material for full sequence representation.

Forecasting↗