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Biomedical subjects

M Dabrowski

Publications and source records attributed to M Dabrowski.

At least 55 records · Page 3Linked to original sources
PubMed1991

Immunophenotypic and functional characterization of peripheral blood mononuclear cell populations in patients with dilated cardiomyopathy.

Cell-mediated immune responsiveness was evaluated in 8 patients with dilated cardiomyopathy (CDM). The percentage of blood OKM1 (monocytes), OKT3 (T-cells), OKT4 (helper cells), OKT8 (suppressor cells) and Leu7 (NK) positive cells remained within the normal range whereas the percentage of Leu11 (NK) and OKIa1 (Ia determinant) positive cells was found to be decreased. The natural killer (NK) cell cytotoxicity was significantly lowered. The ConA-suppressor cell activity was seen to be enhanced while the responsiveness of lymphocytes to ConA was diminished. Thus, no consistent numerical changes in lymphocyte subsets were observed in patients with CDM. Some functional deficiencies were, however, detected, and it is possible that these may play a role in the pathogenesis of CDM.

Adult↗
PubMed1991

[Clinical evaluation of incomplete PTCA revascularization efficacy].

UNLABELLED: Long term results of incomplete PTCA revascularization (IR) were estimated in 89 patients (P) with multivessel disease (MVD). P were divided into four groups according to severity and localization of stenoses on coronary angiography. Type A (n = 23): two or more stenoses greater than or equal to 70%, one of which localized in proximal segment was dilated, others in peripheral segments of major epicardial vessels or their branches were left. Type B (n = 30): stenosis greater than or equal to 70% in proximal part of one artery was dilated, other moderate stenoses 50-70% were left. Type C (n = 26): one coronary artery occluded, second vessel with stenosis greater than or equal to 70% was dilated. Type D (n = 10): one or two coronary arteries occluded, in two or three others stenosis 70%, vessel crucial for collateral flow was dilated. On follow-up (x 17.7 months), 57 (64.1%) P were completely free of angina, 23 (25.8%) had only mild effort angina with good response to NTG. Only 9 (10.1%) P required coronary bypass surgery, 6 of them with type D MVD. CONCLUSIONS: 1. IR gives satisfactory long term results in P with type A, B, C of MVD; 2. IR is a palliative procedure in high risk surgical P with type D of MVD, but in some cases gives good clinical results.

Angioplasty, Balloon, Coronary↗
PubMed1991

[Disturbances of myocardial perfusion by exertion scintigraphy in patients with hypertrophic cardiomyopathy and their relationship with sudden death risk factors].

Heart muscle perfusion was studied by exertion scintigraphy Tal-201 in 24 patients, 16M and 8F, aged 16-45 years, means--28 +/- 7.4 years with hypertrophic cardiomyopathy. The relationship between perfusion disturbances and sudden death risk factors occurring in this group of patients was evaluated. Disturbances of heart muscle perfusion were found in 20 pts (83%); 2 pts had permanent perfusion defects, in 18 pts these defects were completely or partially reversible at rest. Only 4 pts (17%) had normal heart muscle perfusion. In patients with perfusion disturbances there was found a significantly more frequent occurrence of the following sudden death risk factors: 1. syncope (p less than .01) 2. ventricular arrhythmia of IV b class according to Lown (p less than .01) 3. advanced hypertrophy of intraventricular septum (p less than .01) 4. sudden death in patients families (p less than .05) The evaluation of the heart muscle perfusion confirmed the occurrence of myocardial ischemia in most of the examined patients. Normal coronaro-angiography in all the patients over 35 years as well as the young age of the other patients exclude atherosclerosis as the cause of myocardiac ischemia in the group under study. This is a confirmation of nonatherosclerotic etiology of myocardiac ischemia in hypertrophic cardiomyopathy patients. The correlation between perfusion disturbances and sudden death risk factors points to the role of ischemia in the natural course of disease and the value of exertion scintigraphy TI-201 in prognosing patients with hypertrophic cardiomyopathy.

Adolescent↗
PubMed1990

[Complex hemodynamic analysis of left ventricular systole in hypertrophic cardiopathy--clinical implications].

Hypertrophic cardiomyopathy is characterized by hemodynamic disturbances concerning left ventricular systole and diastole. Both of them are probably connected with abnormal structure of myocardium. The aim of the study was to assess left ventricular sufficiency, LV contractility and answer the question: if there is relationship between hemodynamic disturbances and clinical state. Estimation of verapamil influence on evaluated parameters was performed in the second part of the study. 20 patients (13 M, 7 F) aged 16-59 years (mean age 33, 25 yrs) with various type of hypertrophic cardiomyopathy were studied. Catheterization of the right and left heart and coronarography were performed in each patient. The first pressure derivative (d/P/dt) was recorded simultaneously with left ventricular pressure recording. Left ventricular angiography was performed in RAO 30 degrees and LAO 60 degrees projections. Analysis of the angiographic image of the whole heart cycle every 40 ms was performed to evaluate the changes in the left ventricular volume and LV wall thickness. Relationships between left ventricular pressure and volume were defined using computer PDP 11/24. To define verapamil influence, 6 patients received 10 mg of the drug intravenously, 14 patients received verapamil directly into left coronary artery 0.02 mg/kg of 0.5 mg/min. Control blood pressure measurements were performed after 5 and 10 minutes, and ventriculography after 15 min. Obtained results were compared with the control group consisted of 10 patients with normal hemodynamic data. Left ventricular contractility was estimated using V max and power/volume relationship (stress/volume). Both indices showed decreased left ventricular muscle contractility in hypertrophic cardiomyopathy. Verapamil had no significant effect on left ventricular contractility in our patients. Ejection period was studied using few indices. Ejection volume and net work (strokework) of the left ventricle were found to be decreased significantly, what means decreased mechanical preformance. The most significant were differences concerning mechanical performance which did not change after verapamil administration whereas circumferential fibre shortening velocity (VCF) was found to be decreased. If was probably related to increased afterload which could be caused by ventricular kinetics change. Midsystolic stress and the afterload index, significantly lower in cardiomyopathic patients. Preload was similar in both groups. Ejection indices of decreased afterload and normal preload proved decreased contractility. If above changes were primary, hypertrophy might be the compensating mechanism of decreased myocardial sufficiency in patients with hypertrophic cardiomyopathy. Which proved Hiroto's and Furabayashi's. The lack of negative effect verapamil on LV contractility in the group of our patients was very interesting, and could be partially related to beneficial effects in diastole.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1990

Sensitivity of canine Staphylococcus intermedius strains to the phages typing Staphylococcus aureus isolated from man.

98 staphylococci strains isolated from skin lesions of dogs were tested for their morphological, physiological and biochemical characteristics. These examinations have proved that the majority of the strains was Staphylococcus intermedius (n = 97), and only one was Staphylococcus aureus. The strains were also tested for their sensitivity to bacteriophages. Most of Staphylococcus intermedius strains (n = 75) could be typed with the set of human phages, typing staphylococci isolated from man. Two phages, 676 and Phi 131 have turned out to be highly active towards a large number of the isolates.

Animals↗
PubMed1990

[Complex angioplasty (PTCA) in the treatment of coronary artery stenosis].

56 patients with more than one stenotic coronary artery were treated by complex PTCA with success rate of 96.4%. Complications occurred in 3.6% of pts. Restenoses were found in 9.4% of pts; only one of the dilated arteries were restenosed. 11.3% of pts had repeated PTCA, because of progression of stenosis in other than previously treated artery. Angina occurred earlier in pts with restenoses than in pts with progression of stenoses. Late efficacy (mean 19 months) of complex PTCA was high (90.7%).

Adult↗
PubMed1990

[Myocardial bridging as an isolated angiographic change in the anterior descending branch of the left coronary artery].

Review of 1,900 cineangiograms revealed myocardial bridging in 15 patients. 6 patients with more than 75% systolic narrowing in LAD, no evidence of significant atherosclerotic coronary disease, and normal ventricular wall motion underwent further investigation which included clinical examination, ECG and exercise test. All patients suffered from uncharacteristic chest pain. Abnormal ECG showed no specific changes of ST segment. In 4 patients an exercise was positive. All investigated patients were treated with nifedipine. After 6 month therapy myocardial perfusion was evaluated by exercise radionuclide Th-201 myocardial scintigraphy. Normal perfusion was stated in 2 patients. In 4 others perfusion deficits were observed in LAD distribution. Exercise test repeated during therapy was positive in 2 of cases. Chest pain was less severe in all treated patients and Ecg became normal in 2 of them.

Cineangiography↗
PubMed1990

[Coronarography in 1000 consecutive patients--clinical aspects].

Between 1984 and 1987 1000 consecutive patients with stated or suspected ischemic heart disease underwent selective coronarography and left ventriculography. Patient's age ranged from 23 to 70 years (mean - 47 yrs). Atherosclerotic lesions in three main coronary arteries: left anterior descending, circumflex and right coronary artery were assessed. Stenosis exceeding 50% of a vessel lumen was considered as a significant one. Changes were evaluated in the whole group of patients and in two subgroups in relation to patients age (younger and older than 40 years). Besides assessment of atherosclerotic changes in coronary arteries a presence of IHD risk factors, family occurrence, disease progress and methods of further therapy were analyzed. 60.9% of patients had a documented history of myocardial infarction in the post. Unchanged coronary arteries were found in 77 patients (7.7%), one isolated coronary artery stenosis in 145, single coronary artery stenosis with nonsignificant atherosclerotic lesions in other arteries in 328. Two significantly narrowed arteries were found in 285 patients and 101 subjects had significant changes in three coronary arteries. Analysis of further therapy revealed following results: 520 patients underwent PTCA or CABG (270 - PTCA and 250 - CABG), 439 were conservatively treated and only 41 did not need further cardiological care. Comparing atherosclerotic changes in patients younger and older than 40 years, a statistically significant correlation between patient's age and a number of coronary artery stenosis was stated. Diffuse coronary atherosclerosis more frequently occurred in patients more than 40 years. In youngers changes mainly concern a single coronary artery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Favorable outcome of decompression of the trigeminal nerve in a case of bilateral neuralgia].

A case of the bilateral trigeminal neuralgia produced by compression of the V cranial nerve roots by the branch of the anterior lower cerebral artery and post-hemorrhagic aggregates is presented. Complete recovery was obtained in the result of 2-stage, intracranial relief of the right and left trigeminal nerve roots. Neurologists share the opinion that intracranial surgical relief of the V cranial nerve root produces favourable result in case of trigeminal neuralgia resistant to pharmacotherapy.

Arteries↗
PubMed1989

A single step centrifugation method for the enrichment of veiled cells from canine afferent lymph.

Veiled cells (VC) present in the afferent lymph of dogs with chronic lymphoedema could be enriched from 6% to about 50% VC by density gradient centrifugation on 15% metrizamide or discontinuous Percoll gradients. The recovery of VC was about 40% from 0.22 +/- 0.07 X 10(6) VC/ml of lymph. The cells were strongly Ia positive and had cytoplasmic S 100 protein. They were also strongly ATP-ase positive and showed heterogeneity in acid phosphatase, peroxidase and non-specific esterase activity. Low density VC from canine afferent lymph were able to stimulate both blood and lymphatic lymphocytes in autologous mixed leukocyte reaction when present at concentration as low as 5% of cultured cells.

Acid Phosphatase↗
PubMed1989

Spontaneously active suppressive cells in canine peripheral blood.

The phenomenon of the unusually high spontaneous suppressive activity of cells in peripheral blood of dogs was analysed. The m/c (mitomycin C)-treated population of peripheral blood leucocytes (PBL) contained cells able to reduce the responsiveness of autologous cells by 48 +/- 15% (P less than 0.01) and their activity was not indomethacin dependent. Thoracic duct lymphocytes (TDL) did not reduce the response of PBL to PHA, neither did cell crowding. The supernatants from 24-h cultures of m/c-treated PBL did not affect the response to PHA, and parallelly precultured cells inhibited the proliferation of PBL to a lesser degree (24 +/- 9%) than the fresh cells (50 +/- 16%, P less than 0.05). Addition of m/c-treated polymorphonuclear cells at PMN to PBL ratios of 1:4 and 1:1 progressively inhibited PBL reactivity to PHA, from 29.5 +/- 3.5% to 68.5 +/- 9%, respectively, and the supernatants from 24-h cultures of PMN reduced the proliferation by 48 +/- 2.8%. The neutrophil-derived inhibitory factor(s) was non-cytotoxic and reduced the formation of blasts to 61.5 +/- 3.5% of the control values. These results indicate that dog PBL from Lymphoprep gradient contain a population of non-recirculating, short-lived, spontaneously suppressive cells, mainly PMN, which modulate T cell reactivity in vitro, suggesting that neutrophils may be able to exert a regulatory effect in vivo.

Animals↗
PubMed1989

[Sudden death risk factors in patients with hypertrophic cardiomyopathy].

In 79 patients aged 13-65 (mean 36.6) with different types of the hypertrophic cardiomyopathy ECG Holter's monitorings, M-mode and 2-dimensional echocardiographic examinations as well as hemodynamic ones were performed. Ventricular arrhythmias were observed in ECG Holter's recordings in 59.9% of patients. More frequent occurrence of higher grades (3, 4, 5 grades by Lown's classification) of ventricular arrhythmias were stated in patients with significantly thicker intraventricular septum, increase of a left ventricular ejection fraction and a lower left ventricular myocardial mass. There were observed 7 patients without significant forms of ventricular arrhythmias in ECG 24-hours monitoring, but with several, coexisting, well known in literature sudden cardiac death risk factors such as: history of cardiac arrest, sudden cardiac death occurrences in a family before the age of 50, preexcitation syndrome, ecg repolarization disorders, history of fainting, physical activity performance or mental stress. It was stated, that risk of severe ventricular arrhythmias occurrence or a sudden cardiac death in patients with coexisting several, above mentioned, risk factors is higher than in remaining patients with the hypertrophic cardiomyopathy.

Adolescent↗
PubMed1989

[Cardiac rhythm disorders in patients with hypertrophic cardio- myopathy detected by ECG monitoring by the Holter method].

24-hours Holter's ecg monitoring was performed in 79 patients with the hypertrophic cardiomyopathy. Ventricular arrhythmias were recorded in 75.9% of patients, including those revealed in the second recording in 29.5% of patients. Subsequent ecg monitoring was especially useful in detection of complex forms of ventricular arrhythmias (in 27.5%). Average doses of verapamil and Beta-adrenergic blockers were not sufficient in the antiarrhythmic therapy. There was no close correlation between ventricular arrhythmias and a morphologic type of a cardiomyopathy. Patients with episodes of fainting or loss of consciousness require repeated Holter's ecg monitorings.

Adolescent↗
PubMed1989

[Angioplasty in acute and chronic occlusion of the coronary arteries].

An attempt of mechanical restoration of coronary artery patency and its angioplasty was carried out in 37 patients including 9 with acute myocardial infarction within 5 hours after the onset of an angina pain. The procedure was effective in 17 patients (45.9%), including 6 with acute myocardial infarction (66.7%). Mean time of a coronary artery occlusion was 5.1 weeks in the group with a good result in comparison with 17.2 weeks in the group with the unsuccessful procedure. In patients in whom restoration of a coronary artery patency was carried out within up to 3 months after its occlusion the procedure was effective in 64 per cent of them. Effectiveness of restoration of a coronary artery patency and its dilatation depends on the time from its occlusion to the procedure. The early attempt of the restoration of a coronary artery patency is effective in the majority of patients. In cases of the unsuccessful recanalization of a coronary artery occluded for a short time the main limitation of the procedure effectiveness was the vessel anatomy. The follow-up of 17 patients after a successful procedure showed restenosis or reocclussion in 6 of them (35%). It was referred in 1 case to the patient in whom restoration of a vessel patency was carried out during acute myocardial infarction (17%), and in 5 others to patients with a chronic occlusion of a coronary artery (45.5%).

Acute Disease↗
PubMed1989

[Results of long-term verapamil treatment of patients with hypertrophic cardiomyopathy].

In 50 patients with different forms of hypertrophic cardiomyopathy the effect of many months (mean 23.3 +/- 15.7) therapy with verapamil was estimated. Interventricular septum thickness, isovolumetric relaxation period (IRP), "a" wave amplitude were evaluated as well as changes of parameters indirectly testifying to intraventricular obstruction such as: abnormal systolic anterior mitral leaflet motion (SAM) and midsystolic aortic valve closure (AVC). Pre- and post therapy physical efficacy was estimated basing on effort duration. Results were compared with those observed in a group of 20 patients with hypertrophic cardiomyopathy not treated with calcium channel antagonists. Verapamil therapy resulted in inhibition of a disease progression and in diminution of interventricular septum thickness respectively in 74% and 48% of patients. Differences are significant in comparison with a control group. Characteristics of diastole was improved almost in a half of verapamil patients. In the majority of cases, active diastolic period improvement was referred to patients with nonobstructive cardiomyopathy forms and corresponded with their physical fitness improvement. Verapamil resulted in diminution or regression of SAM and AVC in patients with obstructive forms and most likely caused physical efficacy improvement in some of them. The study also confirmed that the group of patients with hypertrophic cardiomyopathy is not homogenous one with regard to morphology of hypertrophy, hemodynamics, disease progression and response to therapy. Observed differences do not always depend on a cardiomyopathy form which suggests that the applied nowadays classification is not sufficient.

Adult↗
PubMed1989

Cellular immune response in patients with dilated cardiomyopathy.

Cell-mediated immune responsiveness was evaluated in 8 patients with dilated cardiomyopathy (CDM). The percentage of blood OKM1 (monocytes), OKT3 (T-cells), OKT4 (helper cells), OKT8 (suppressor cells) and Leu7 (NK) positive cells remained within the normal range whereas the percentage of Leu11 (NK) and OKIa1 (Ia determinant) positive cells was found decreased. The NK cell cytotoxicity was significantly lowered. The ConA-suppressor cell activity was found increased while the responsiveness of lymphocytes to ConA decreased. Taken together, no consistent numerical changes in lymphocyte subsets were observed in patients with CDM, however, some functional deficiencies which may play a role in the pathogenesis of CDM were detected.

Adult↗
PubMed1989

[Use of photogrammetry for evaluating the effectiveness of percutaneous transluminal coronary angioplasty].

In 16 patients which underwent PTCA of a right or left coronary artery, analysis of coronarographic image using the stecometer (a precise instrument measuring background coordinates) was performed. Segment of a coronary artery in which PTCA was performed, was estimated in projections: RAO 30 degrees and LAO 60 degrees with a cranial 30 degrees-45 degrees view before and after the procedure. Totally, 72 arteriograms were evaluated. Measurements data were processed by a computer under a written program. Obtained results were presented digitally as a coordinates list and graphically as automatically plotted by Digigraf, drawings in the scale of 10:1 or 20:1. Obtained results were convergent with the hitherto applied method of coronary arteries stenoses approximate assessment.

Angioplasty, Balloon, Coronary↗