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Biomedical subjects

M Dabrowski

Publications and source records attributed to M Dabrowski.

At least 73 records · Page 4Linked to original sources
PubMed1988

The estimation of usefulness of Pseudomonas bacteriophages in epidemiological investigations of Pseudomonas aeruginosa clinical strains.

Out of 20 Pseudomonas phages, 17 were most suitable for typing of Pseudomonas aeruginosa strains isolated from different sources of human infections. These phages have been classified into three taxons based on coefficient of correlation of their lytic activity. Out of these strains only one appeared nontypeable. 240 distinquished phagotypes were classified into three groups and seven subgroups. This schema of classification was used in the epidemiological investigations of the Pseudomonas strains in relation to the category of infection and the place of isolation. Some statisticaly significant differences were detected. Various possibilities of applications of typing set of Pseudomonas phages are discussed.

Bacteriophage Typing↗
PubMed1987

Studies on bacteriophage penetration in patients subjected to phage therapy.

Two healthy volunteers and 56 patients with suppurative bacterial infections were tested for penetration of oral administered bacteriophage to the blood circulation system and urinary tract. In the blood and urine samples collected from patients before phage therapy application, no presence of "wild phages" was confirmed. Examination performed on the 10th day of phage therapy revealed the presence of bacteriophages in 47 of 56 blood samples tested; positive result of examination was obtained in 9 cases of 26 urine samples.

Administration, Oral↗
PubMed1987

Bacteriophage treatment of suppurative skin infections.

The study material comprised 31 patients with chronic suppurative infections of the skin caused by Pseudomonas, Staphylococcus, Klebsiella, Proteus and Escherichia. Within 2-16 weeks of the treatment, an improvement of the general state was observed as well as suppression of the local inflammation, purification of a wound from the suppurative and necrotic content, faster healing of the ulcers and fully negative results of the bacteriologic tests. In 16 cases, an outstanding therapeutic effect was obtained, in 7 cases marked improvement was reported and in 2 a transitory improvement was reported. In 7 patients the treatment was abandoned due to the lack of improvement (1 case) or development of side effects (6 cases). The results obtained provide evidence for the high effectiveness of phage therapy in the treatment of suppurative skin infections.

Adolescent↗
PubMed1987

Results of bacteriophage treatment of suppurative bacterial infections in the years 1981-1986.

In the years 1981-1986 bacteriophage therapy was applied in 550 cases (100 treated in 1986) of suppurative bacterial infections. Positive results were obtained in 508 cases (92.4%). In 38 cases (6.9%) a transient improvement was observed and in 4 cases (0.7%) phage treatment proved ineffective. Considering that majority of patients (518 cases, 94.2%) were resistant to antibiotic treatment, the results of phage therapy may be regarded as favorable.

Adolescent↗