PubMed Health⌕ Search

Biomedical subjects

M Dabrowski

Publications and source records attributed to M Dabrowski.

At least 91 records · Page 5Linked to original sources
PubMed1985

Profiles of biopsy-proven cases with myocarditis.

Fifty-seven patients with unexplained dilated hearts and congestive heart failure were studied clinically and by endomyocardial biopsy of the left ventricle. Of the patients, 61% had histologic evidence of active lymphocytic myocarditis. The sudden onset of heart failure, often with arrhythmias, if preceded by a viral-like illness indicated a high chance of finding inflammatory infiltration in the biopsy material. No abnormal accumulation of immunoglobulin was found in these patients with dilated cardiomyopathy and myocarditis. Immunosuppressive therapy did not always bring about improvement.

Biopsy↗
PubMed1985

Results of bacteriophage treatment of suppurative bacterial infections. IV. Evaluation of the results obtained in 370 cases.

The results of phage therapy applied in 370 cases of suppurative bacterial infections were analyzed. Positive therapeutic results were obtained in 342 (92.4%) cases. The results obtained confirmed the previous findings on great effectiveness of bacteriophages in the treatment of septic infections, spontaneous or postoperative, caused by pyogenic Staphylococci, Klebsiella, Escherichia, Proteus and Pseudomonas bacteria.

Adolescent↗
PubMed1985

Results of bacteriophage treatment of suppurative bacterial infections. V. Evaluation of the results obtained in children.

The results of phage therapy applied in 114 cases of suppurative bacterial infections in children were analyzed. Positive therapeutic results were obtained in 109 (95.6%) cases. The results confirmed great effectiveness of bacteriophages in the treatment of septic infections, spontaneous or postoperative, caused by pyogenic Staphylococci, Klebsiella, Escherichia, Proteus and Pseudomonas bacteria.

Adolescent↗
PubMed1985

Results of bacteriophage treatment of suppurative bacterial infections. VI. Analysis of treatment of suppurative staphylococcal infections.

Analysis of phage therapy results was carried out on 273 cases of spontaneous and postoperative septic staphylococcal infections. The treatment appeared effective in 254 (93.0%) cases. Detailed analysis of the results obtained in particular disease categories revealed that staphylococcal bacteriophages may be efficiently applied in the treatment of suppurative staphylococcal infections resistant to antibiotics.

Adolescent↗
PubMed1984

Immunotherapy of chronic active viral hepatitis B with propionibacterium granulosum.

12 HBsAg-positive patients with chronic active hepatitis B were treated monthly with cell walls (5 or 10 mg) of Propionibacterium granulosum KP-45 (PG) intravenously administered for a period of 6-10 months. The clinical state was evaluated according to an arbitrary 6-grade scale based on serum biochemical tests, HBV markers and the morphology of liver biopsy samples. Intravenous administration of PG was well tolerated, and no serious side effects were observed. All patients exhibited complete or partial normalization of biochemical parameters and HB5AG and DNA-polymerase levels were decreasing after 6 months of therapy. Prior to treatment, HBeAG was detected in 9 patients, in 4 of whom seroconversion occurred with appearance of anti-HBeAg. Excellent results were seen in 3 patients and beneficial results in a further 3 patients; signs of improvement were seen in 5 patients, and only one patient did not react in a clearly positive way. In 11 of these patients, before and during treatment, isolated peripheral blood lymphocytes were investigated for their ability to show rosette E formation, their reactivity to phytomitogens (PHA, ConA), and their suppressor T lymphocyte activity. In five patients interferon levels were investigated.

Adjuvants, Immunologic↗
PubMed1984

Results of bacteriophage treatment of suppurative bacterial infections. III. Detailed evaluation of the results obtained in further 150 cases.

The results of phage therapy applied in further 150 cases of suppurative bacterial infections were analyzed. Positive therapeutic results were obtained in 137 cases (91.3%). The results obtained confirmed the previous findings on great effectiveness of bacteriophages in the treatment of septic infections, spontaneous or postoperative, caused by pyo genic Staphylococci, Klebsiella, Escherichia, Proteus and Pseudomonas.

Adolescent↗
PubMed1983

Synergistic effects of ATS and passive and active enhancement on heart and skin allografts in rats.

The effect of a combination of specific and non-specific immunosuppression on survival of heart and skin allografts in parental strain rats differing across the major histocompatibility locus was investigated. Pretreatment of the recipient with donor specific antigen and anti-donor alloantiserum prolonged the survival of heart grafts but not skin grafts. The use of antilymphocyte serum prolonged skin graft survival but not heart graft survival. However, when ATS was combined with donor specific immunosuppression, both heart and skin graft survival were prolonged dramatically. It is suggested that these treatment modalities affect differentially various aspects of the immune responses.

Animals↗
PubMed1983

Results of bacteriophage treatment of suppurative bacterial infections. I. General evaluation of the results.

One hundred and thirty eight septic cases were treated with specific bacteriophages. According to the International Classification of the Diseases (WHO, 1977), the treated cases were divided to 9 categories. Nearly all cases were long-term infections with antibiotic resistant organisms. Only specific bacteriophages were used in association with several types of surgical procedure. The technique of treatment is described. In 129 (93.5%) cases the results were good, in 9 (6.5%) cases local improvement was observed. It is concluded that bacteriophage therapy may be helpful in the treatment of long-term suppurative infections.

Adolescent↗
PubMed1983

Results of bacteriophage treatment of suppurative bacterial infections. II. Detailed evaluation of the results.

The results of treatment with specific bacteriophages of 184 nosologic units diagnosed in 138 cases as septic bacterial infections, presented in the first part of this report, were submitted to detailed analysis. The results obtained revealed that phage therapy may be successfully applied in the treatment of septic infections induced by Staphylococcus, Klebsiella, Escherichia, Proteus and Pseudomonas as well as of the digestive system infections induced by Shigella and Salmonella. They also widened the scope of phage therapy application.

Adolescent↗