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Biomedical subjects

M Dandel

Publications and source records attributed to M Dandel.

25 records · Page 2Linked to original sources

Successful mechanical circulatory support for more than two years with a left ventricular assist device in a patient with dilated cardiomyopathy.

A 36-year-old man with dilated cardiomyopathy was supported with a left ventricular assist device for 795 days. During this support time gradual functional recovery was noted. The patient tolerated the device well, enjoyed a good quality of life, and experienced no technical device-related problems. When a suitable donor heart became available, the device was switched off, and native ventricular function was assessed. This was judged to be acceptable, and the left ventricular assist device was successfully explanted. Postexplantation function remained acceptable and improved over the following days. The patient was discharged on the twentieth postoperative day and remains well.

Adult↗

Effect of age on systolic intervals (STI).

Weissler's corrected STI was to be used in the assessment of cardiac performance taking into account only the heart rate and sex. But there are many other determinants of STI, among them an important one is the age. In the present paper, in 422 normal adults (280 men and 142 women) divided according the age into three groups (20-29, 30-39, 40-60 years), we found significant differences concerning STIc with age, especially over 40 years old. On the other hand, in a previous paper we have found in trained athletes similar modifications of STIc as those noticed in cardiac failure. That is why we, like other authors, do not consider Weissler's STIc as valid in the assessment of cardiac performance.

Adult↗

Characteristic features concerning the action of prostaglandin F2 alpha (PGF2 alpha) on the microvascular territories drained by truncus jugularis.

In dogs, PGF2 alpha injected into the Arteria facialis increases the local blood flow and microvascular permeability accompanied by an important increase of lymph and salivary flow. The results of our investigations allowed us to speculate that PGF2 alpha may be an important component of the regulatory mechanism underlying salivary secretion.

Animals↗