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Biomedical subjects

M De Negri

Publications and source records attributed to M De Negri.

At least 37 records · Page 2Linked to original sources
PubMed1988

Generalized epilepsy in childhood: some notes from a developmental perspective.

Efforts to establish more detailed classification of childhood epilepsy have increased our knowledge in this field, but have also led to a tendency of excessive subdivision, especially in generalized forms. This paper emphasizes the need for the reconsideration of a number of basic factors that favour a more unitary physiopathogenetic and clinical interpretation: 1) the electroclinical pattern is age-related; 2) the electroclinical paroxysmal expressiveness is greatest in childhood; 3) two types of manifestations can be distinguished in the process of spread and generalization (a benzodiazepine-sensitive complex associated with a more regular and organized EEG pattern, and a corticotropin-sensitive complex associated with an irregular, unorganized EEG pattern).

Brain↗
PubMed1988

Secondary generalized epilepsy in childhood: EEG patterns and correlation with responsiveness to benzodiazepines or ACTH (preliminary note).

Secondary generalized epilepsy in childhood, characterized by absences or minor motor seizures, occurs in the forms of various syndromes, as defined by current classifications. EEG often shows continuous or subcontinuous paroxysmal activity associated with partly reversible psychomotor or mental regression. The paroxysmal activity can exhibit one of two distinct patterns: "organized" or "disorganized," although intermediate forms are common. The two patterns differ not only morphologically but also in the responsiveness to drug or hormone therapy, reactivity to stimuli, sleep changes and frequency of disordered slow rhythms. These features are illustrated by means of a survey of 10 cases.

Adolescent↗
PubMed1981

Antimicrobic activity of the amniotic fluid.

The amniotic fluid is commonly, though not unanimously, believed to include among its various functions a defensive one, against infections. This is due to the presence of immunoglobulins, immunocompetent cells and such factors like lysozyme, transferrin and zinc. However, evidence of this AF antimicrobic activity had been found only in the second half of the pregnancy period starting from the 20th gestational week. Our study has demonstrated its presence in a very high percentage (58.7%) of AF samples taken in early amniocenteses.

Adult↗
PubMedDate not supplied

Hyperkinetic behaviour, attention deficit disorder, conduct disorder and instabilité psychomotrice: identity, analogies, and misunderstandings. Commentary to Gordon's paper (Brain Dev 1994; 15: 169-72).

'Hyperkinetic behaviour', 'attention deficit disorder' and 'conduct disorder' with antisocial aspects or delinquency are concepts frequently superimposed. They can be traced back to the classic nosological entity, 'instabilité psychomotrice', still used in French psychiatric nosography. In this paper, the different components of the condition are analyzed (emotional, attentional, posturo-motoric and behavioural) both in normal subjects and in cases of mild encephalopathies, and for different age groups. A criticism is advanced towards the undifferentiated approach to the problem in the most current literature.

Attention Deficit Disorder with Hyperactivity↗
PubMedDate not supplied

Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test.

The effects of rapid rectal diazepam introduction (DZP test) were investigated in 43 patients (age range 5 months-14 years) with electrical status epilepticus (ESE) undergoing EEG monitoring. A remission of the paroxysmal activity was obtained in 58% of cases, a negative response in 42%, particularly in hypsarrhythmic patterns. DZP test responders were aged over 12 months with organized paroxysmal EEG patterns, in particular with ESE during sleep (ESES). The patients who responded to the DZP test underwent short cycles (3-4 weeks) of relatively high dosage DZP (0.5-0.75 mg/kg). The response to treatment was positive in 64%, particularly in ESES conditions. 56% of responders to the DZP test but not to DZP therapy (five out of nine patients) presented a significant mental retardation; maturational factors were also likely to be present.

Administration, Oral↗