The in vitro biosynthesis of steroids by the gonad of the cuttlefish (Sepia officinalis L.).
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Biomedical subjects
Publications and source records attributed to M Drosdowsky.
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Aspermatogenic seminiferous tubules were incubated in presence of labelled testosterone. This steroid is converted into androstenedione and 5 alpha-dihydro-testosterone. This finding favours the hypothesis which gives the Sertoli cell an important role in germ cell maturation.
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In order to obtain reference values from normal babies, Cr status of full-term newborns has been studied. Plasma and urine values were (mean +/- SEM) 0.7 +/- 0.1 micrograms/L and 0.9 +/- 0.3 micrograms/L, respectively, for the first month of life (n = 19), and 0.6 +/- 0.1 micrograms/L and 0.8 +/- 0.2 micrograms/L for the second-to-third-month period (n = 31). Premature newborns (gestational age 28-36 wk) were compared to these control values; concentrations were 0.9 +/- 0.1 micrograms/L and 1.1 +/- 0.2 micrograms/L for the first month (n = 47), and 1.0 +/- 0.2 micrograms/L and 1.5 +/- 0.3 micrograms/L for the second to third months (n = 27). For the whole group, there was a positive correlation between plasma and urine concentrations (p = 0.0001); multiple regression analysis was performed between plasma levels and gestational age at birth (p = -0.002) and postnatal age (NS). Plasma levels of prematures and full terms were statistically different (p = 0.03) only for the second- to third-month period. It is suggested that these high Cr levels result from high dietary intakes and/or high absorption rates.
Plasma Cr concentrations have been studied in normal children aged 0-14 yr. Levels ranged from 0.65 to 0.88 microgram/l and did not change with age. Plasma concentrations of CF patients given 0.5-0.75 microgram Cr/kg/d in addition to their diet were similar to normal values. There was no correlation between these plasma values and growth retardation.
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