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Biomedical subjects

M Eibl

Publications and source records attributed to M Eibl.

89 records · Page 5Linked to original sources
PubMed1975

[IgM antibody deficiency with normal serum IgM concentration in a family (author's transl)].

A 5 years old child with selective antibody deficiency having slight hypogammaglobulinaemia of the IgG-class, normal IgM and absence of IgA has been described. The patient had no isoagglutinins and no heteroagglutinins against rabbits. Antibodies of the IgG-class could be detected in a very low concentration. The child had repeated severe infections, f. e. 5 attacks of pneumonia. After diagnosis of selective antibody deficiency syndrome had been made, he has been treated with high dose gammaglobulin therapy every 4 weeks. The child did not have any severe infections since that time. Diagnostic and therapeutic possibilities in patients with selective antibody deficiency were discussed.

Antibody Formation↗
PubMed1975

[Tuberculous meningitis and antibody deficiency disease (author's transl)].

A 13 year old girl not vaccinated with BCG became ill with tuberculous meningitis. After administration of 30 g of Streptomycin, cell counts and protein concentrations of the cerebro-spinal fluid returned to normal values. After continuation of antituberculous therapy without Streptomycin, the patient relapsed, and Streptomycin had to be given for 14 months. Defect in humoral immunity was diagnosed with low IgG and low titers of antiviral antibodies. For this reason the patient was additionally treated with passive administration of antibodies.

Adolescent↗
PubMedDate not supplied

[The septic state in infancy].

In a retrospective study it was investigated in which a course the septicemia appears during the first year of life and which laborchemical and immunological findings are typical for the specific manifestation and can be used for the diagnosis. 27 sucklings with septicemia were admitted at our hospital during 1976-1982. As the clinical course we found: the acute septicemia with pronounced shocksymptoms (Septic-Toxic-Course, STC), the septicemia with a tardy course and hematogenous dispersion of bacteria in one organsystem, namely in the brain (Meningoencephalitis), in the bone (Osteomyelitis) and in the soft tissue (Phlegmon), the septicemia with a tardy course and forms a septicopyemia with secundary dispersion of bacteria in multiple organsystems. Only STC and septicopyemia show the symptoms which are lead back with the dispersion of bacteria. By the septicemia with a tardy course and hematogenous dispersion of bacteria in one organsystem the clinical symptoms are determined only in the infected organ. As the only course of septicemia the STZ shows laborchemically in the blood a damage to the livercells with a constant elevated levels of plasmaencyms GOT, GPT and LDH; this findings can be used for a diagnostic criterion. By septicopyemia, meningitis and osteomyelitis the findings of sepsis exist in the blood but are rare by phlegmon. By septicemia with a tardy course (2, 3) a humoral and/or cellular immundeficiency exist. This is a point of application for therapy to give biological antibody with a large spectrum.

Antibody Formation↗
PubMedDate not supplied

Enteroviral meningoencephalitis in immunocompromised children after matched unrelated donor-bone marrow transplantation.

Two children are described who presented with fever and generalized seizures, days 50 and 200, respectively, after matched unrelated donor-bone marrow transplantation. Upon antiepileptic treatment the seizures vanished but somnolence and fever remained. Magnetic resonance imaging (MRI) of the brain was performed and revealed transient asymmetric multifocal hyperintense lesions. Seizures were considered related to infection, and the cyclosporin A (CsA) treatment was not interrupted. Enterovirus was detected by reverse transcriptase-polymerase chain reaction in the spinal fluid of one patient and in the sputum of the other. Both children recovered completely within the next weeks without neurological sequel. This report shows that enteroviral meningoencephalitis can present with seizures during the post-transplant period. It highlights the importance of MRI for neuroimaging and of viral infections as differential diagnosis to CsA neurotoxicity.

Adolescent↗
PubMedDate not supplied

[EA rosettes in patients with progressive chronic polyarthritis].

One subpopulation of human lymphocytes contains Fc-receptors that form rosettes with antibody (IgG) coated human erythrocytes (EA-rosettes). On the average 8.9% of the lymphocytes from patients with rheumatoid arthritis (RA) form EA-rosettes compared with 5.3% in controls. When the lymphocytes were washed three times the EA-rosettes increased to 21.2% for RA patients and 9.5% for controls. This procedure thus reveals more Fc-receptors on the lymphocytes from RA patients than on those from healthy controls. The number of T-lymphocytes was normal in RA patients and controls, no matter how many times the lymphocytes were washed.

Adult↗
PubMedDate not supplied

[Results of the treatment of children with brain neoplasms. I. Survival of children and cause of death].

In a group of 146 children aged from 8 months to 16 years treated for brain neoplasms the authors analysed the therapeutic results. Excluding the so called operative losses the survival over 4 years was obtained in one-fourth of patients with medulloblastoma, in over one-third of those with ependymoma, one-half of astrocytoma cases, and over one-third of children with other neoplasms. The authors estimate positively the therapeutic methods used (operation, radiotherapy and chemotherapy by Bloom's schedule) and see the possibility of increasing the survival rate by improvement in the diagnosis of brain tumours in children and by optimalization of treatment, especially in its early period, for reducing the number of operative losses.

Adolescent↗