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Biomedical subjects

M F Chen

Publications and source records attributed to M F Chen.

At least 325 records · Page 18Linked to original sources

Transcatheter hepatic arterial embolization followed by hepatic resection for the spontaneous rupture of hepatocellular carcinoma.

In three cases of the spontaneous rupture of hepatocellular carcinoma, emergent transcatheter hepatic arterial embolization was performed for controlling the intraperitoneal hemorrhage. No more transfusions were required after embolization. Operation was carried out on the 10th, 5th, and 5th day, respectively, after liver function studies returned to the pre-embolization level. Hepatic resection of left hemi-hepatectomy was performed in Case 1, and segmentectomy in Case 2 and Case 3 each. Transcatheter hepatic arterial embolization followed by hepatic resection is a rational treatment in the management of the spontaneous rupture of hepatocellular carcinoma.

Adult↗

Increased bone marrow blood flow in rabbits with acute hemolytic anemia.

The bone marrow blood flow in the femur of the rabbit with acute hemolytic anemia was measured by the radioactive microsphere method. Acute hemolytic anemia was induced by a single intraperitoneal injection of phenylhydrazine. An increase in the bone marrow blood flow was detected three days after the induction of anemia and continued for about one week. The bone marrow blood flow of the anemic rabbit (66 ml/min/100 g marrow) was about three times that of the control (20 ml/min/100 g marrow). The increased blood flow to the bone marrow appeared to be correlated to the increased erythropoietic activity.

Acute Disease↗

Downward displacement of aortic anulus leading to aortic and mitral regurgitation.

A rare case of combined aortic and mitral regurgitation resulting from downward displacement of the aortic anulus is reported. The patient was treated successfully with an aortic valve replacement with a Björk-Shiley valve prosthesis, which was anchored at the normal site of the aortic anulus. No procedures were performed on the mitral valve, but mitral regurgitation was not evident postoperatively.

Adult↗

Thyroid function in epileptic mothers and their infants at birth.

It has been suggested that patients receiving anticonvulsant therapy have depressed thyroid function. Thyroid function was studied in 16 pregnant epileptic women who were receiving various anticonvulsants; 20 nonepileptic pregnant women served as controls. Maternal and umbilical cord blood was collected at delivery and serum thyrotropin, total thyroxine, triiodothyronine, triiodothyronine resin uptake, and free thyroxine levels were measured. The free thyroxine index was calculated from the thyroxine and triiodothyronine resin uptake data. There were no significant differences in any of the maternal parameters. In cord serum, the thyroxine level was significantly lower (p less than 0.001) in the infants of the epileptic mothers. The triiodothyronine resin uptake was slightly increased in the epileptic group (p less than 0.05) so that the free thyroxine index largely compensated for this. The thyrotropin, free thyroxine, and triiodothyronine levels did not differ between the two groups. Thus the low thyroxine values in cord blood of infants of epileptic mothers receiving anticonvulsants probably reflect an alteration in protein binding rather than a true alteration in thyroid function.

Anticonvulsants↗

Sonographic appearance of cytomegalovirus nephritis in a neonate.

In adults and children increased renal cortical echogenicity on ultrasound examination is now well recognized as a feature of renal parenchymal disease due to a variety of etiologies. The degree of echogenicity appears related to the severity of the renal disease, histologically. The sonographic renal pattern of the neonate and in particular, of the premature, differs generally from that of the adult in that the renal cortex of the very young may be "normally" more echogenic than in later life. Marked cortical echogenicity however, is a sign of renal parenchymal disease even in the premature, as illustrated in the case that follows with documented cytomegalovirus nephritis.

Cytomegalovirus Infections↗